DNA binding behaviour of mixed ligand vanadium(V) complex based on novel tridentate hydrazone and benzhydroxamic acid ligand systems

2016 ◽  
Vol 31 (3) ◽  
pp. e3573 ◽  
Author(s):  
Poonam Inamdar ◽  
Sheela Angappan
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Acid Ligand ◽  
Benzhydroxamic Acid ◽  
Binding Behaviour

scholarly journals Contrasting DNA-binding behaviour by ISL1 and LHX3 underpins differential gene targeting in neuronal cell specification

2020 ◽  
pp. 100043
Author(s):  
Ngaio C. Smith ◽  
Lorna E. Wilkinson-White ◽  
Ann H.Y. Kwan ◽  
Jill Trewhella ◽  
Jacqueline M. Matthews
Keyword(s):  
Dna Binding ◽  
Gene Targeting ◽  
Neuronal Cell ◽  
Cell Specification ◽  
Differential Gene ◽  
Binding Behaviour

Mixed ligand Ni(II) complexes: DNA binding, oxidative and photo-cleavage studies

2008 ◽  
Vol 7 (2) ◽  
pp. 97-107 ◽  
Author(s):  
M. C. Prabhakara ◽  
H. S. Bhojya Naik
Keyword(s):  
Dna Binding ◽  
Mixed Ligand ◽  
Photo Cleavage

scholarly journals Two related ARID family proteins are alternative subunits of human SWI/SNF complexes

2004 ◽  
Vol 383 (2) ◽  
pp. 319-325 ◽  
Author(s):  
Xiaomei WANG ◽  
Norman G. NAGL ◽  
Deborah WILSKER ◽  
Michael VAN SCOY ◽  
Stephen PACCHIONE ◽  
...  
Keyword(s):  
Dna Binding ◽  
Direct Evidence ◽  
Potential Interaction ◽  
Atpase Subunit ◽  
Reading Frame ◽  
Atpase Subunits ◽  
A Subunit ◽  
Distinct Subunit ◽  
Binding Behaviour

p270 (ARID1A) is a member of the ARID family of DNA-binding proteins and a subunit of human SWI/SNF-related complexes, which use the energy generated by an integral ATPase subunit to remodel chromatin. ARID1B is an independent gene product with an open reading frame that is more than 60% identical with p270. We have generated monoclonal antibodies specific for either p270 or ARID1B to facilitate the investigation of ARID1B and its potential interaction with human SWI/SNF complexes in vivo. Immunocomplex analysis provides direct evidence that endogenous ARID1B is associated with SWI/SNF-related complexes and indicates that p270 and ARID1B, similar to the ATPase subunits BRG1 and hBRM, are alternative, mutually exclusive subunits of the complexes. The ARID-containing subunits are not specific to the ATPases. Each associates with both BRG1 and hBRM, thus increasing the number of distinct subunit combinations known to be present in cells. Analysis of the panels of cell lines indicates that ARID1B, similar to p270, has a broad tissue distribution. The ratio of p270/ARID1B in typical cells is approx. 3.5:1, and BRG1 is distributed proportionally between the two ARID subunits. Analysis of DNA-binding behaviour indicates that ARID1B binds DNA in a non-sequence-specific manner similar to p270.

Photophysical properties and DNA binding studies of novel Eu 3+ mixed ligand complex

2016 ◽  
Vol 177 ◽  
pp. 416-424 ◽  
Author(s):  
Sneha R. Wankar ◽  
Umar Jan Pandit ◽  
Imran Khan ◽  
S.N. Limaye
Keyword(s):  
Dna Binding ◽  
Photophysical Properties ◽  
Mixed Ligand Complex ◽  
Mixed Ligand ◽  
Binding Studies ◽  
Ligand Complex ◽  
Dna Binding Studies

scholarly journals Mathematical modelling of promoter occupancies in MYC-dependent gene regulation

2017 ◽  
Vol 3 (2) ◽  
pp. 54
Author(s):  
Uwe Benary ◽  
Elmar Wolf ◽  
Jana Wolf
Keyword(s):  
Dna Binding ◽  
Mathematical Modelling ◽  
Expression Patterns ◽  
Cell Types ◽  
Osteosarcoma Cell ◽  
Genome Wide ◽  
Human Osteosarcoma Cell ◽  
Cell Type Specific ◽  
Binding Behaviour ◽  
Oncogene Protein

The human MYC proto-oncogene protein (MYC) is a transcription factor that plays a major role in the regulation of cell proliferation. Deregulation of MYC expression is often found in cancer. In the last years, several hypotheses have been proposed to explain cell type specific MYC target gene expression patterns despite genome wide DNA binding of MYC. In a recent publication, a mathematical modelling approach in combination with experimental data demonstrated that differences in MYC-DNA-binding affinity are sufficient to explain distinct promoter occupancies and allow stratification of distinct MYC-regulated biological processes at different MYC concentrations. Here, we extend the analysis of the published mathematical model of DNA-binding behaviour of MYC to demonstrate that the insights gained in the investigation of the human osteosarcoma cell line U2OS can be generalized to other human cell types.

Mixed-Ligand Cu(II) Carboxylates: Synthesis, Crystal Structure, FTIR, DNA Binding, Antidiabetic, and Anti-Alzheimer’s Studies

2019 ◽  
Vol 64 (11) ◽  
pp. 1365-1378 ◽  
Author(s):  
Afifa Mushtaq ◽  
Saqib Ali ◽  
Muhammad Nawaz Tahir ◽  
Ali Haider ◽  
Hammad Ismail ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Mixed Ligand
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