Aminopropylated PEG as a novel, eco-friendly and biodegradable basic catalyst for bis-Michael addition to α,β-unsaturated ketones under solvent-free conditions

2014 ◽  
Vol 28 (8) ◽  
pp. 620-630 ◽  
Author(s):  
Tabassum Khan ◽  
Zeba N. Siddiqui
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Basic Catalyst ◽  
Unsaturated Ketones ◽  
Solvent Free Conditions

Iodine-catalyzed Michael addition of mercaptans to α,β-unsaturated ketones under solvent-free conditions

2005 ◽  
Vol 46 (30) ◽  
pp. 4971-4974 ◽  
Author(s):  
Cheng-Ming Chu ◽  
Shijay Gao ◽  
M.N.V. Sastry ◽  
Ching-Fa Yao
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Unsaturated Ketones ◽  
Solvent Free Conditions

Iodine-Catalyzed Michael Addition of Mercaptans to α,β-Unsaturated Ketones under Solvent-Free Conditions.

ChemInform ◽  
2005 ◽  
Vol 36 (43) ◽  
Author(s):  
Cheng-Ming Chu ◽  
Shijay Gao ◽  
M. N. V. Sastry ◽  
Ching-Fa Yao
Keyword(s):  
Michael Addition ◽  
Solvent Free ◽  
Unsaturated Ketones ◽  
Solvent Free Conditions

Highly efficient regioselective synthesis of pyrroles via a tandem enamine formation–Michael addition–cyclization sequence under catalyst- and solvent-free conditions

2015 ◽  
Vol 17 (6) ◽  
pp. 3415-3423 ◽  
Author(s):  
Thavaraj Vivekanand ◽  
Perumal Vinoth ◽  
B. Agieshkumar ◽  
Natarajan Sampath ◽  
Arumugam Sudalai ◽  
...  
Keyword(s):  
Column Chromatography ◽  
Michael Addition ◽  
Solvent Free ◽  
Regioselective Synthesis ◽  
Highly Efficient ◽  
Solvent Free Conditions ◽  
Enamine Formation

An efficient three-component, catalyst-, solvent-, and column chromatography-free procedure was developed for the synthesis of 3-(1H-pyrrol-3-yl)indolin-2-ones.

Use of (R)-Mandelic Acid as Chiral Co-Catalyst in the Michael Addition Reaction Organocatalyzed by (1S,4S)-2-Tosyl-2,5-diazabicyclo[2.2.1]heptane under Solvent-Free Conditions

2015 ◽  
Vol 2 (1) ◽  
Author(s):  
C. Gabriela Ávila-Ortiz ◽  
Manuel López-Ortiz ◽  
Alberto Vega-Peñaloza ◽  
Ignacio Regla ◽  
Eusebio Juaristi
Keyword(s):  
Michael Addition ◽  
Mandelic Acid ◽  
Addition Reaction ◽  
Solvent Free ◽  
Reaction Intermediates ◽  
Michael Addition Reaction ◽  
Co Catalyst ◽  
Co Catalysts ◽  
Solvent Free Conditions ◽  
The Michael Addition

AbstractThis article describes a study on the Michael addition reaction of cyclohexanone to nitroolefins catalyzed by the chiral secondary amine (1S,4S)-2-tosyl- 2,5-diazabicyclo[2.2.1]heptane. Reactions were carried out under solvent-free conditions to make them more environmentally friendly. Initially, the observed diastereoand enantioselectivities were moderate to good, but were significantly improved by lowering the reaction temperature. Furthermore, a variety of chiral acids were also tested as co-catalysts in both of their enantiomeric forms, which revealed that (R)-mandelic acid affords excellent results in terms of yield and stereoselectivity. Monitoring the reaction by MS-TOF allowed for the detection of key reaction intermediates, and a reasonable reaction mechanism in which both catalysts are involved is proposed.

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