The Role of Organic Synthesis in the Emergence and Development of Antibody–Drug Conjugates as Targeted Cancer Therapies

2019 ◽  
Vol 58 (33) ◽  
pp. 11206-11241 ◽  
Author(s):  
K. C. Nicolaou ◽  
Stephan Rigol
Keyword(s):  
Organic Synthesis ◽  
Cancer Therapies ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Targeted Cancer Therapies ◽  
Antibody Drug

scholarly journals Antibody–Drug Conjugates for Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (20) ◽  
pp. 4764
Author(s):  
Umbreen Hafeez ◽  
Sagun Parakh ◽  
Hui K. Gan ◽  
Andrew M. Scott
Keyword(s):  
Monoclonal Antibody ◽  
Molecular Imaging ◽  
Cancer Therapy ◽  
Normal Tissue ◽  
Clinical Development ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Novel Drugs ◽  
Antibody Drug

Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry of each component of ADC design. We briefly discuss the clinical experience with approved ADCs and the various pathways involved in ADC resistance. We conclude with perspectives about the future development of the next generations of ADCs, including the role of molecular imaging in drug development.

Abstract 4470: Elucidating the role of drug-linker hydrophobicity in the disposition of antibody-drug conjugates

2014 ◽  
Author(s):  
Svetlana O. Doronina ◽  
Jocelyn R. Setter ◽  
Tim D. Bovee ◽  
Martha E. Anderson ◽  
Mechtild Jonas ◽  
...  
Keyword(s):  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug

Abstract 4750: The role of drug transporters in the acquired resistance to PBD dimer-containing antibody drug conjugates

2019 ◽  
Author(s):  
Simon Corbett ◽  
Francesca Zammarchi ◽  
Philip W Howard ◽  
Patrick H van Berkel ◽  
John A Hartley
Keyword(s):  
Drug Transporters ◽  
Acquired Resistance ◽  
Antibody Drug Conjugates ◽  
Drug Conjugates ◽  
Antibody Drug
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