Synthesis of Eight‐Membered Lactams through Formal [6+2] Cyclization of Siloxy Alkynes and Vinylazetidines

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Chintan S. Sumaria ◽  
...  

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...  

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Tetrahedron ◽  
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Jianwei Sun

Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging.


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2006 ◽  
Vol 37 (48) ◽  
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Sergey A. Kozmin
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