scholarly journals Disulfide‐Unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA

2019 ◽  
Vol 58 (20) ◽  
pp. 6611-6615 ◽  
Author(s):  
Zhaoma Shu ◽  
Iku Tanaka ◽  
Azumi Ota ◽  
Daichi Fushihara ◽  
Naoko Abe ◽  
...  
Keyword(s):  
Author(s):  
Kilian Vogele ◽  
Elisabeth Falgenhauer ◽  
Sophie von Schönberg ◽  
Friedrich C. Simmel ◽  
Tobias Pirzer

2019 ◽  
Vol 131 (20) ◽  
pp. 6683-6687 ◽  
Author(s):  
Zhaoma Shu ◽  
Iku Tanaka ◽  
Azumi Ota ◽  
Daichi Fushihara ◽  
Naoko Abe ◽  
...  
Keyword(s):  

2010 ◽  
Vol 46 (23) ◽  
pp. 4151 ◽  
Author(s):  
Jae-Hong Kim ◽  
Hyun Hye Jang ◽  
Sang-Mi Ryou ◽  
Sudeok Kim ◽  
Jeehyeon Bae ◽  
...  

1989 ◽  
Vol 9 (10) ◽  
pp. 4479-4487
Author(s):  
M Cotten ◽  
G Schaffner ◽  
M L Birnstiel

A comparative analysis of ribozyme, antisense RNA, and antisense DNA inhibitors of the in vitro small nuclear ribonucleoprotein U7-dependent histone pre-mRNA processing reaction was performed. RNA molecules complementary to the U7 sequence inhibited in vitro processing of histone pre-mRNA at a sixfold excess over U7. Single-stranded DNA complementary to the entire U7 sequence inhibited the reaction at a 60-fold excess over U7, while a short, 18-nucleotide DNA molecule complementary to the 5' end of U7 inhibited the processing reaction at a 600-fold excess. A targeted ribozyme was capable of specifically cleaving the U7 small nuclear ribonucleoprotein in a nuclear extract and inhibited the U7-dependent processing reaction, but in our in vitro system it required a 1,000-fold excess over U7 for complete inhibition of processing.


2001 ◽  
pp. 82-83
Author(s):  
R. Oberbauer
Keyword(s):  

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