Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation

2018 ◽  
Vol 57 (50) ◽  
pp. 16533-16537 ◽  
Author(s):  
Naoki Kamo ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
One Pot ◽  
Peptide Ligation

scholarly journals Corrigendum: Triple Function of 4‐Mercaptophenylacetic Acid Promotes One‐Pot Multiple Peptide Ligation

2019 ◽  
Vol 58 (6) ◽  
pp. 1540-1540
Author(s):  
Naoki Kamo ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
One Pot ◽  
Peptide Ligation

scholarly journals Berichtigung: Triple Function of 4‐Mercaptophenylacetic Acid Promotes One‐Pot Multiple Peptide Ligation

2019 ◽  
Vol 131 (6) ◽  
pp. 1554-1554
Author(s):  
Naoki Kamo ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
One Pot ◽  
Peptide Ligation

scholarly journals One-Pot Peptide Ligation–Desulfurization at Glutamate

2013 ◽  
Vol 16 (1) ◽  
pp. 290-293 ◽  
Author(s):  
Katie M. Cergol ◽  
Robert E. Thompson ◽  
Lara R. Malins ◽  
Peter Turner ◽  
Richard J. Payne
Keyword(s):  
One Pot ◽  
Peptide Ligation

Singlet oxygen-mediated one-pot chemoselective peptide–peptide ligation

2017 ◽  
Vol 15 (38) ◽  
pp. 8140-8144 ◽  
Author(s):  
Eirini Antonatou ◽  
Yentl Verleysen ◽  
Annemieke Madder
Keyword(s):  
Singlet Oxygen ◽  
One Pot ◽  
Specific Chemical ◽  
Chemical Ligation ◽  
Site Specific ◽  
Peptide Segments ◽  
Peptide Ligation

We here describe a furan oxidation based site-specific chemical ligation approach using unprotected peptide segments.

scholarly journals Thiazolidine Deprotection by 2-Aminobenzamide-Based Aldehyde Scavenger for One-Pot Multiple Peptide Ligation

2021 ◽  
Author(s):  
Koki Nakatsu ◽  
Hitoshi Murakami ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
Native Chemical Ligation ◽  
High Yield ◽  
Side Reactions ◽  
Model Peptide ◽  
One Pot ◽  
Chemical Ligation ◽  
Good Ability ◽  
Synthetic Proteins ◽  
Short Time ◽  
Peptide Ligation

Strategies for one-pot peptide ligation enable chemists to access synthetic proteins at a high yield in a short time. Herein, we report a new one-pot multi-segments ligation strategy using N-terminal thiazolidine (Thz) peptide and a formaldehyde scavenger. Among our designed 2-aminobenzamide-based aldehyde scavengers, 2-amino-5-methoxy-N’,N’-dimethylbenzohydrazide showed a good ability to capture formaldehyde from Thz at pH 4.0. This scavenger had compatibility with the conditions of native chemical ligation at pH 7.5. Using this scavenger for a model peptide ligation system, we performed one-pot four-segment ligation at a high yield without significant side reactions.

scholarly journals Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry

2014 ◽  
Vol 136 (23) ◽  
pp. 8161-8164 ◽  
Author(s):  
Robert E. Thompson ◽  
Xuyu Liu ◽  
Noelia Alonso-García ◽  
Pedro José Barbosa Pereira ◽  
Katrina A. Jolliffe ◽  
...  
Keyword(s):  
One Pot ◽  
Peptide Ligation

Efficient peptide ligation between allyl-protected Asp and Cys followed by palladium-mediated deprotection

2018 ◽  
Vol 54 (34) ◽  
pp. 4337-4340 ◽  
Author(s):  
Naoki Kamo ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
One Pot ◽  
Peptide Ligation

Difficult peptide ligation between Asp and Cys and subsequent deprotection proceeded in one pot by adding a small amount of Pd/TPPTS complex.

Triple Function of 4-Mercaptophenylacetic Acid Promotes One-Pot Multiple Peptide Ligation

2018 ◽  
Vol 130 (50) ◽  
pp. 16771-16775 ◽  
Author(s):  
Naoki Kamo ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
One Pot ◽  
Peptide Ligation

One-pot native chemical ligation by combination of two orthogonal thioester precursors

2017 ◽  
Vol 53 (13) ◽  
pp. 2114-2117 ◽  
Author(s):  
Yuya Asahina ◽  
Toru Kawakami ◽  
Hironobu Hojo
Keyword(s):  
Native Chemical Ligation ◽  
Protecting Group ◽  
One Pot ◽  
Chemical Ligation ◽  
Ligation Reaction ◽  
Ligation Method ◽  
Peptide Ligation

We developed a one-pot peptide ligation method using two orthogonal thioester precursors and a protecting group for the ligation reaction between Asp and Cys.

scholarly journals Thiazolidine Deprotection by 2-Aminobenzamide-Based Aldehyde Scavenger for One-Pot Multiple Peptide Ligation

2021 ◽  
Author(s):  
Koki Nakatsu ◽  
Hitoshi Murakami ◽  
Gosuke Hayashi ◽  
Akimitsu Okamoto
Keyword(s):  
Native Chemical Ligation ◽  
High Yield ◽  
Side Reactions ◽  
Model Peptide ◽  
One Pot ◽  
Chemical Ligation ◽  
Good Ability ◽  
Synthetic Proteins ◽  
Short Time ◽  
Peptide Ligation

Strategies for one-pot peptide ligation enable chemists to access synthetic proteins at a high yield in a short time. Herein, we report a new one-pot multi-segments ligation strategy using N-terminal thiazolidine (Thz) peptide and a formaldehyde scavenger. Among our designed 2-aminobenzamide-based aldehyde scavengers, 2-amino-5-methoxy-N’,N’-dimethylbenzohydrazide showed a good ability to capture formaldehyde from Thz at pH 4.0. This scavenger had compatibility with the conditions of native chemical ligation at pH 7.5. Using this scavenger for a model peptide ligation system, we performed one-pot four-segment ligation at a high yield without significant side reactions.

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