PNA Hybrid Sequences as Recognition Units in SNARE-Protein-Mimicking Peptides

2018 ◽  
Vol 57 (45) ◽  
pp. 14932-14936 ◽  
Author(s):  
Barbara E. Hubrich ◽  
Pawan Kumar ◽  
Hermann Neitz ◽  
Matthias Grunwald ◽  
Tobias Grothe ◽  
...  
Keyword(s):  
Snare Protein ◽  
Mimicking Peptides

scholarly journals 1,2,3-Triazoles as Biomimetics in Peptide Science

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2937
Author(s):  
Naima Agouram ◽  
El Mestafa El Hadrami ◽  
Abdeslem Bentama
Keyword(s):  
Enzymatic Degradation ◽  
Triazole Ring ◽  
Biologically Active ◽  
Amide Bond ◽  
Biologically Relevant ◽  
Amide Bonds ◽  
Natural Peptides ◽  
Mimicking Peptides ◽  
Chemical Mediators

Natural peptides are an important class of chemical mediators, essential for most vital processes. What limits the potential of the use of peptides as drugs is their low bioavailability and enzymatic degradation in vivo. To overcome this limitation, the development of new molecules mimicking peptides is of great importance for the development of new biologically active molecules. Therefore, replacing the amide bond in a peptide with a heterocyclic bioisostere, such as the 1,2,3-triazole ring, can be considered an effective solution for the synthesis of biologically relevant peptidomimetics. These 1,2,3-triazoles may have an interesting biological activity, because they behave as rigid link units, which can mimic the electronic properties of amide bonds and show bioisosteric effects. Additionally, triazole can be used as a linker moiety to link peptides to other functional groups.

Genetisch bedingte Hauterkrankungen – Xeroderma pigmentosum und das CEDNIK-Syndrom

2020 ◽  
Vol 46 (08/09) ◽  
pp. 375-378
Author(s):  
M. C. Martens ◽  
L. Boeckmann ◽  
S. Emmert
Keyword(s):  
Xeroderma Pigmentosum ◽  
Snare Protein ◽  
Loss Of Function

ZusammenfassungDie Rostocker Hautklinik ist Europäisches Referenznetzwerkzentrum für seltene Hauterkrankungen mit den besonderen Schwerpunkten Xeroderma pigmentosum und Ichthyosen. Diese Themen vertreten wir auch in der medizinischen Grundlagenforschung.Xeroderma pigmentosum (XP) ist eine seltene, autosomal-rezessive Erkrankung, die entsprechend der Gendefekte in 7 Komplementationsgruppen – XP-A bis XP-G sowie die sog. XP-Variante (XP-V) – eingeteilt wird. XP ist ein Nukleotid-Exzisions-Reparatur-Defektsyndrom und äußert sich v. a. durch vorzeitige Hautalterung und frühzeitige Entwicklung von Hauttumoren.Das seltene, neurokutane CEDNIK-Syndrom ist eine autosomal-rezessive Erkrankung, der eine Loss-of-Function-Mutation in SNAP29 zugrunde liegt. SNAP29 ist ein SNARE-Protein und an intrazellulären Membranfusionen beteiligt. CEDNIK ist ein Akronym für den mit dem Syndrom assoziierten Symptomkomplex aus zerebraler Dysgenese, Neuropathie, Ichthyose und Palmoplantarkeratosen. CEDNIK-Patienten weisen neben der Ichthyose zudem Gedeihstörungen, eine psychomotorische Retardierung und faziale Dysmorphien auf.

scholarly journals Membrane fusion mediated by peptidic SNARE protein analogues: Evaluation of FRET‐based bulk leaflet mixing assays

2021 ◽  
Author(s):  
Barbara E. Hubrich ◽  
Jan‐Dirk Wehland ◽  
Mike C. Groth ◽  
Anastasiya Schirmacher ◽  
Raphael Hubrich ◽  
...  
Keyword(s):  
Membrane Fusion ◽  
Snare Protein

SNARE protein expression in synaptic terminals and astrocytes in the adult hippocampus: A comparative analysis

Glia ◽  
2011 ◽  
Vol 59 (10) ◽  
pp. 1472-1488 ◽  
Author(s):  
Vanessa Schubert ◽  
David Bouvier ◽  
Andrea Volterra
Keyword(s):  
Comparative Analysis ◽  
Protein Expression ◽  
Snare Protein ◽  
Synaptic Terminals ◽  
Adult Hippocampus

scholarly journals The transmembrane domain of the SNARE protein VAMP2 is highly sensitive to its lipid environment

2019 ◽  
Vol 1861 (3) ◽  
pp. 670-676 ◽  
Author(s):  
Zahia Fezoua-Boubegtiten ◽  
Benoit Hastoy ◽  
Pier Scotti ◽  
Alexandra Milochau ◽  
Katell Bathany ◽  
...  
Keyword(s):  
Transmembrane Domain ◽  
Snare Protein ◽  
Highly Sensitive ◽  
Lipid Environment

Magnetically complexed tissue-mimicking peptides

2005 ◽  
Vol 97 (10) ◽  
pp. 10M521
Author(s):  
R. P. Guertin ◽  
R. Valluzzi ◽  
T. E. Haas ◽  
D. Pochan
Keyword(s):  
Mimicking Peptides

Identification of Three New Splice Variants of the SNARE Protein SNAP-23

2001 ◽  
Vol 285 (2) ◽  
pp. 320-327 ◽  
Author(s):  
Alok Shukla ◽  
Thomas Juhl Corydon ◽  
Søren Nielsen ◽  
Hans Jürgen Hoffmann ◽  
Ronald Dahl
Keyword(s):  
Splice Variants ◽  
Snare Protein
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