Carbohydrate-Responsive Surface Adhesion Based on the Dynamic Covalent Chemistry of Phenylboronic Acid- and Catechol-Containing Polymer Brushes

2018 ◽  
Vol 57 (9) ◽  
pp. 2474-2478 ◽  
Author(s):  
Sebastian Lamping ◽  
Tobias Otremba ◽  
Bart Jan Ravoo
Keyword(s):  
Polymer Brushes ◽  
Phenylboronic Acid ◽  
Surface Adhesion ◽  
Dynamic Covalent Chemistry

scholarly journals Controlled Surface Adhesion of Macrophages via Patterned Antifouling Polymer Brushes

2020 ◽  
pp. 2000029 ◽  
Author(s):  
Johannes Striebel ◽  
Mariia Vorobii ◽  
Ravi Kumar ◽  
Hui-Yu Liu ◽  
Bingquan Yang ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Surface Adhesion

scholarly journals Supramolecular surface adhesion mediated by azobenzene polymer brushes

2016 ◽  
Vol 52 (9) ◽  
pp. 1964-1966 ◽  
Author(s):  
Oliver Roling ◽  
Lucas Stricker ◽  
Jens Voskuhl ◽  
Sebastian Lamping ◽  
Bart Jan Ravoo
Keyword(s):  
Polymer Brushes ◽  
Atom Transfer ◽  
Surface Adhesion ◽  
Cyclodextrin Polymer ◽  
Azobenzene Polymer ◽  
Radical Polymerisation

Surface immobilised polymer brushes containing azobenzenes were prepared using microcontact chemistry and surface-initiated atom transfer radical polymerisation. Two surfaces bearing brushes can be glued together in the presence of a β-cyclodextrin polymer.

Responsive surface adhesion based on host–guest interaction of polymer brushes with cyclodextrins and arylazopyrazoles

2019 ◽  
Vol 10 (6) ◽  
pp. 683-690 ◽  
Author(s):  
Sebastian Lamping ◽  
Lucas Stricker ◽  
Bart Jan Ravoo
Keyword(s):  
Uv Irradiation ◽  
Polymer Brushes ◽  
Surface Adhesion ◽  
Strong Surface

Polymer brushes functionalized with cyclodextrin host and arylazopyrazole guest monomers provide strong surface adhesion that is water resistent but can be deactivated by UV irradiation.

scholarly journals Phenylboronic acid modification augments the lysosome escape and antitumor efficacy of a cylindrical polymer brush-based prodrug

2021 ◽  
Author(s):  
Ruonan Wang ◽  
Changfeng Yin ◽  
Changren Liu ◽  
Ying Sun ◽  
Panpan Xiao ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Drug Loading ◽  
Phenylboronic Acid ◽  
Polymer Brush ◽  
Specific Interactions ◽  
Acid Modification ◽  
Tumor Penetration ◽  
Lysosomal Membrane Proteins ◽  
Shock Proteins ◽  
First Time

Abstract Timely lysosome escape is very important for nanomedicines to avoid premature degradation. Herein, we report an exciting finding that phenylboronic acid (PBA) modification can greatly facilitate the lysosome escape of cylindrical polymer brushes (CPBs), and further promote their exocytosis and transcellular transfer. This fundamental finding for the first time reveals that PBA groups improve the tumor penetration of nanomaterials via an active transcytosis mechanism. We speculate that the mechanism of the PBA-enhanced lysosome escape is associated with the specific interactions of the PBA group with the lysosomal membrane proteins and hot shock proteins. The featured advantage of the PBA modification over the known lysosome escape strategies is that it does not cause significant adverse effects on the properties of the CPBs. Furthermore, doxorubicin was conjugated to the PBA-modified CPBs with drug loading content larger than 20%. This CPBs-based prodrug could eradicate the tumors established in mice by multiple intravenous administration.

scholarly journals Dynamic Covalent Chemistry-based Sensing: Pyrenyl Derivatives of Phenylboronic Acid for Saccharide and Formaldehyde

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Xingmao Chang ◽  
Jiayun Fan ◽  
Min Wang ◽  
Zhaolong Wang ◽  
Haonan Peng ◽  
...  
Keyword(s):  
Phenylboronic Acid ◽  
Dynamic Covalent Chemistry ◽  
Derivatives Of

Forces between asymmetric polymer brushes

1990 ◽  
Vol 51 (8) ◽  
pp. 701-707 ◽  
Author(s):  
D.F.K. Shim ◽  
M. E. Cates
Keyword(s):  
Polymer Brushes

Nanostructured Polymer Brushes With Reversibly Changing Properties

2002 ◽  
Vol 727 ◽  
Author(s):  
Denys Usov ◽  
Manfred Stamm ◽  
Sergiy Minko ◽  
Christian Froeck ◽  
Andreas Scholl ◽  
...  
Keyword(s):  
Polymer Brushes ◽  
Phase Segregation ◽  
Water Contact ◽  
Angle Measurements ◽  
Nanostructured Polymer ◽  
Contact Angle Measurements ◽  
Vertical Segregation ◽  
Oxygen Plasma Etching ◽  
Grafting From ◽  
Photoemission Electron

AbstractWe investigated the interplay between different mechanisms of the lateral and vertical segregation in the synthesized via “grafting from” approach symmetric A/B (where A and B are poly(styrene-co-2,3,4,5,6-pentafluorostyrene) and poly(methylmethacrylate), respectively) polymer brushes upon exposure to different solvents. We used X-ray photoemission electron spectroscopy and microscopy (X-PEEM), AFM, water contact angle measurements, and oxygen plasma etching to study morphology of the brushes. The ripple morphology after toluene (nonselective solvent) revealed elongated lamellar-like domains of A and B polymers alternating across the surface. The dimple-A morphology consisting of round clusters of the polymer A was observed after acetone (selective solvent for B). The top layer was enriched with the polymer B showing that the brush underwent both the lateral and vertical phase segregation. A qualitative agreement with predictions of SCF theory was found.

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