Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel-Mediated One-Pot Ketone Synthesis as the Final Coupling Reaction

2017 ◽  
Vol 56 (36) ◽  
pp. 10796-10800 ◽  
Author(s):  
Kenzo Yahata ◽  
Ning Ye ◽  
Yanran Ai ◽  
Kentaro Iso ◽  
Yoshito Kishi
Keyword(s):  
Coupling Reaction ◽  
One Pot ◽  
Scalable Synthesis

Unified, Efficient, and Scalable Synthesis of Halichondrins: Zirconium/Nickel-Mediated One-Pot Ketone Synthesis as the Final Coupling Reaction

2017 ◽  
Vol 129 (36) ◽  
pp. 10936-10940 ◽  
Author(s):  
Kenzo Yahata ◽  
Ning Ye ◽  
Yanran Ai ◽  
Kentaro Iso ◽  
Yoshito Kishi
Keyword(s):  
Coupling Reaction ◽  
One Pot ◽  
Scalable Synthesis

Synthesis of the six isomeric thieno[c]-fused 1,5- and 1,6-naphthyridines

1991 ◽  
Vol 56 (11) ◽  
pp. 2340-2351 ◽  
Author(s):  
Salo Gronowitz ◽  
Johan Malm ◽  
Anna-Britta Hörnfeldt
Keyword(s):  
Nmr Spectra ◽  
Coupling Reaction ◽  
One Pot ◽  
C Nmr

trough the use of Pd(0)-catalyzed coupling between 2- and 4-formyl-3-thiopheneboronic acids and 3-amino-2-bromopyridine and 4-acetamido-3-bromopyridine, convenient one-pot procedures for the preparation of thieno[2,3-c]-1,5-naphthyridine, thieno[3,4-c]-1,5-naphthyridine, thieno-[2,3-c]-1,6-naphthyridine, and thieno[3,4-c]-1,6-naphthyridine have been developed. In order to obtain thieno[3,2-c]-1,6-naphthyridine 2-(tributylstannyl)-3-thiophene aldehyde had to be used, since the organometallic partner in the coupling reaction, 3-formyl-2-thipheneboronic acid, is too easily deboronated. The effect of silver(I) oxide and thallium(I) carbonate on the coupling was studied. 1H and 13C NMR spectra of the six isomeric thieno{c]-fused 1,5- and 1,6-naphthyridines are discussed.

Synthesis of Shape-Persistent Macrocycles by a One-Pot Suzuki-Miyaura Cross-Coupling Reaction

2010 ◽  
Vol 17 (2) ◽  
pp. 440-444 ◽  
Author(s):  
Weiguo Huang ◽  
Ming Wang ◽  
Chun Du ◽  
Yulan Chen ◽  
Ruiping Qin ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
One Pot ◽  
Cross Coupling Reaction

One‐Pot Synthetic Procedure for2,2′‐Disubstituted Biaryls via the Suzuki Coupling Reaction of Aryl Triflates in a Biphasic Solvent System

2006 ◽  
Vol 36 (24) ◽  
pp. 3809-3820 ◽  
Author(s):  
Masanori Miura ◽  
Takanori Koike ◽  
Tsukasa Ishihara ◽  
Fukushi Hirayama ◽  
Shuichi Sakamoto ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Solvent System ◽  
One Pot ◽  
Suzuki Coupling Reaction ◽  
Synthetic Procedure

Unprecedented one-pot multicomponent synthesis of propargylamines using Amberlyst A-21 supported CuI under solvent-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46074-46087 ◽  
Author(s):  
Giovanna Bosica ◽  
John Gabarretta
Keyword(s):  
Coupling Reaction ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Terminal Alkynes ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Solvent Free Conditions

An environmentally benign, one-pot, A3-coupling reaction of various aldehydes, amines and terminal alkynes for the synthesis of propargylamine was catalysed by Amberlyst A-21 supported CuI, under heterogeneous and solvent-free conditions.

ChemInform Abstract: Highly Selective One-Pot Coupling Reaction of Indole, Aromatic Aldehydes, and 4-Hydroxycoumarin Using Copper Octoate as a Homogeneous Catalyst.

ChemInform ◽  
2014 ◽  
Vol 45 (43) ◽  
pp. no-no
Author(s):  
Farnoush Mousavizadeh ◽  
Rahim Hekmatshoar ◽  
Seyed Yahya Shirazi Beheshtiha ◽  
Reyhaneh Rahnamafar
Keyword(s):  
Coupling Reaction ◽  
Aromatic Aldehydes ◽  
Homogeneous Catalyst ◽  
One Pot

A metal-free biaryl coupling reaction activated by a sulfonium salt

2018 ◽  
Vol 5 (22) ◽  
pp. 3219-3225 ◽  
Author(s):  
Kazuhiro Higuchi ◽  
Takuhiro Tago ◽  
Yusuke Kokubo ◽  
Motoki Ito ◽  
Masanori Tayu ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Sulfonium Salt ◽  
One Pot ◽  
Metal Free ◽  
Trifluoromethanesulfonic Anhydride ◽  
Biaryl Coupling ◽  
Aryl Ethers

A metal-free biaryl coupling reaction of phenol or aryl ethers mediated by a sulfonium salt formed from diphenyl sulfoxide and trifluoromethanesulfonic anhydride has been developed. The method is a rapid, one-pot reaction, leaving no traces of the sulfonium moiety in the product.

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