scholarly journals Highly Stereoselective Cobalt(III)-Catalyzed Three-Component C−H Bond Addition Cascade

2016 ◽  
Vol 55 (41) ◽  
pp. 12650-12654 ◽  
Author(s):  
Jeffrey A. Boerth ◽  
Joshua R. Hummel ◽  
Jonathan A. Ellman
Keyword(s):  
Component C

Lanthionine Synthetase Component C-Like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes

2014 ◽  
Vol 15 (6) ◽  
pp. 565-572 ◽  
Author(s):  
Pinyi Lu ◽  
Raquel Hontecillas ◽  
Casandra Philipson ◽  
Josep Bassaganya-Riera
Keyword(s):  
Drug Target ◽  
Inflammatory Diseases ◽  
New Drug ◽  
Component C

scholarly journals Role of component C in the methylreductase system of Methanobacterium.

1980 ◽  
Vol 255 (18) ◽  
pp. 8388-8389 ◽  
Author(s):  
W.L. Ellefson ◽  
R.S. Wolfe
Keyword(s):  
Component C

Paleomagnetism of the Clam Bank Formation and paleolatitude estimates for western Newfoundland

1993 ◽  
Vol 30 (4) ◽  
pp. 776-786
Author(s):  
G. Murthy ◽  
R. Pätzold
Keyword(s):  
North American ◽  
Early Paleozoic ◽  
The North ◽  
Northerly Direction ◽  
Deformation Event ◽  
Recent Origin ◽  
Component C ◽  
Acadian Orogeny ◽  
North American Craton ◽  
Devonian Age

The Pridolian Clam Bank Formation around Lourdes Cove on the Port au Port Peninsula, western Newfoundland, underwent deformation during the Acadian orogeny. As a result, some of the beds were overturned, but the stratification planes can be accurately determined everywhere. Paleomagnetic studies of the Clam Bank Formation have yielded three well-defined components of magnetization, all acquired subsequent to the deformation event: component A with D = 337.3°, I = −28.3°, (N = 16 sites, k = 25.3, α95 = 7.5°), with a corresponding paleopole at 23.2°N, 145.0°E (dp, dm = 4.5°, 8.2°); component B with D = 172.9°, I = 5.7° (N = 35 specimens, k = 10.2, α95 = 6.4°), with a corresponding paleopole at 38.2°N, 130.1°E (dp, dm = 3.2°, 6.4°); component C with D = 350.4°, I = 69.8° (N = 33 specimens, k = 8.9, α95 = 8.9°). A pre-Mesozoic origin of the A and B components is indicated by the presence of normal and reversed components in specific sites; by the lack of correspondence between the A and B paleopoles and the Mesozoic and later pole positions from the Appalachians and the North American craton; and by agreement with Paleozoic poles from the region. The A component was probably acquired immediately after deformation during the Acadian orogeny. The B component is probably a chemical remanence that was acquired during Permo-Carboniferous (Kiaman) time. The C component is of recent origin, probably acquired in the present Earth's field. Paleomagnetic data from western Newfoundland are used in a localized setting to construct a paleopole sequence and to estimate paleolatitudes for western Newfoundland during the Paleozoic. Keeping in mind the paucity of data for Siluro-Devonian age from this region, western Newfoundland seems to have been at its southernmost position at the end of the Ordovician and to have occupied equatorial latitudes during the Permo-Carboniferous. The paleolatitude trend suggests that this block, which is part of the North American craton, moved in a southerly direction during the early Paleozoic and in a northerly direction during the middle and late Paleozoic.

scholarly journals Albumin binding of unconjugated [3H]bilirubin and its uptake by rat liver basolateral plasma membrane vesicles

1996 ◽  
Vol 316 (3) ◽  
pp. 999-1004 ◽  
Author(s):  
Lorella PASCOLO ◽  
Savino DEL VECCHIO ◽  
Ronald K. KOEHLER ◽  
J. Enrique BAYON ◽  
Cecile C. WEBSTER ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Rat Liver ◽  
Basolateral Membrane ◽  
Membrane Vesicles ◽  
Plasma Membrane Vesicles ◽  
Experimental Conditions ◽  
Saturation Kinetics ◽  
Basolateral Plasma Membrane ◽  
Component C ◽  
Uptake Studies

Using highly purified unconjugated [3H]bilirubin (UCB), we measured UCB binding to delipidated human serum albumin (HSA) and its uptake by basolateral rat liver plasma membrane vesicles, in both the absence and presence of an inside-positive membrane potential. Free UCB concentrations ([Bf]) were calculated from UCB–HSA affinity constants (K´f), determined by five cycles of ultrafiltration through a Centricon-10 device (Amicon) of the same solutions used in the uptake studies. At HSA concentrations from 12 to 380 μM, K´f (litre/mol) was inversely related to [HSA], irrespective of the [Bt]/[HSA] ratio. K´f was 2.066×106+(3.258×108/[HSA]). When 50 mM KCl was iso-osmotically substituted for sucrose, the K´f value was significantly lower {2.077×106+(1.099×108/[HSA])}. The transport occurred into an osmotic-sensitive space. Below saturation ([Bf] ⩽ 65 nM), both electroneutral and electrogenic components followed saturation kinetics with respect to [Bf], with Km values of 28±7 and 57±8 nM respectively (mean±S.D., n = 3, P < 0.001). The Vmax was greater for the electrogenic than for the electroneutral component (112±12 versus 45±4 pmol of UCB·mg-1 of protein·15 s-1, P < 0.001). Sulphobromophthalein trans-stimulated both electrogenic (61%) and electroneutral (72%) UCB uptake. These data indicate that: (a) as [HSA] increases, K´f decreases, thus increasing the concentration of free UCB. This may account for much of the enhanced hepatocytic uptake of organic anions observed with increasing [HSA]. (b) UCB is taken up at the basolateral membrane of the hepatocyte by two systems with Km values within the range of physiological free UCB levels in plasma. The electrogenic component shows a lower affinity and a higher capacity than the electroneutral component. (c) It is important to calculate the actual [Bf] using a K´f value determined under the same experimental conditions (medium and [HSA]) used for the uptake studies.

scholarly journals The Decadal Climate Prediction Project

2016 ◽  
Author(s):  
George J. Boer ◽  
Douglas M . Smith ◽  
Christophe Cassou ◽  
Francisco Doblas-Reyes ◽  
Gokhan Danabasoglu ◽  
...  
Keyword(s):  
Decadal Variability ◽  
Climate Prediction ◽  
Decadal Prediction ◽  
Science And Society ◽  
Climate Data ◽  
Climate Shifts ◽  
Component C ◽  
Decadal Climate ◽  
Decadal Climate Prediction ◽  
Ensemble Generation

Abstract. The Decadal Climate Prediction Project (DCPP) is a coordinated multi-model investigation into decadal climate prediction, predictability, and variability. The DCPP makes use of past experience in simulating and predicting decadal variability and forced climate change gained from CMIP5 and elsewhere. It builds on recent improvements in models, in the reanalysis of climate data, in methods of initialization and ensemble generation, and in data treatment and analysis to propose an extended comprehensive decadal prediction investigation as part of CMIP6. The DCPP consists of three Components. Component A comprises the production and analysis of an extensive archive of retrospective forecasts to be used to assess and understand historical decadal prediction skill, as a basis for improvements in all aspects of end-to-end decadal prediction, and as a basis for forecasting on annual to decadal timescales. Component B undertakes ongoing production, dissemination and analysis of experimental quasi-real-time multi-model forecasts as a basis for potential operational forecast production. Component C involves the organization and coordination of case studies of particular climate shifts and variations, both natural and naturally forced (e.g. the "hiatus", volcanoes), including the study of the mechanisms that determine these behaviours. Groups are invited to participate in as many or as few of the Components of the DCPP, each of which are separately prioritized, as are of interest to them. The Decadal Climate Prediction Project addresses a range of scientific issues involving the ability of the climate system to be predicted on annual to decadal timescales, the skill that is currently and potentially available, the mechanisms involved in long timescale variability, and the production of forecasts of benefit to both science and society.

scholarly journals Catalytic Three-component C–C Bond Forming Dearomatization of Bromoarenes with Malonates and Diazo Compounds

2020 ◽  
Author(s):  
Hiroki Kato ◽  
Itsuki Musha ◽  
Masaaki Komatsuda ◽  
Kei Muto ◽  
Junichiro Yamaguchi
Keyword(s):  
Present Method ◽  
Bond Formation ◽  
Diazo Compounds ◽  
Bond Forming ◽  
Rapid Access ◽  
Component C

A Pd-catalyzed dearomative three-component C–C bond formation of bromoarenes with diazo compounds and malonates was developed. Various bromoarenes ranging from benzenoids to azines and heteroles were transformed to the corresponding substituted alicyclic molecules. The key of this reaction is the generation of a benzyl-palladium intermediate, which reacts with malonates to form a Pd–<i>O</i>-enolate species. Strikingly, the present method enabled rapid access to multi-substituted alicycles through subsequent elaboration of dearomatized products.

scholarly journals Evaluation of the Antibacterial Activities of Isolated Bioactive Components from the plant Adenodolichos paniculatus

2021 ◽  
Vol 19 (2) ◽  
pp. 429-447
Author(s):  
A.E. Onwuliri ◽  
I.F. Kyahar ◽  
J.O. Ehinmidu ◽  
P.O. Oladosu
Keyword(s):  
Staphylococcus Aureus ◽  
Pseudomonas Aeruginosa ◽  
Stearic Acid ◽  
Streptococcus Pyogenes ◽  
Antibacterial Activities ◽  
Bioactive Components ◽  
Octadecanoic Acid ◽  
Zones Of Inhibition ◽  
Rf Values ◽  
Component C

The three bioactive components isolated included: component A (major phytochemicals were Bis (2-ethylhexyl) phthalate (16.36 %), 9,12-Octadecadienoic acid, ethyl ether (14.77 %) and 9.cis., 11.trans.-octadecadie noate (14.77 %), component B (major phytochemicals were 9,12-Octadecadienal (Linoleic acid) (40.98 %), Octadecanoic acid (Stearic acid) (9.26 %), Undecanoic acid, 10-bromo- (10-bromoudecanoic acid) (9.26 %) and n-Hexadecanoic acid (Palmitic acid) and component C (cis-9-octadecenoic acid (Oleic Acid) (30.45 %), Octadecanoic acid (Stearic acid) (17.33 %)). These components isolated from the chloroform fraction of Adenodolichos paniculatus are used by traditional medicinal practitioners for the management of mouth and throat infections. The antibacterial activities against Streptococcus pyogenes, Staphylococcus aureus and Pseudomonas aeruginosa were evaluated using bioautography and agar-well diffusion methods. The bioautogram result showed that component A had inhibited spots against S. pyogenes (17.50 mm) and P. aeruginosa (16.00 mm), corresponding to the TLC spots with Rf values of 0.594, 0.55 and 0.26, respectively. Component B showed inhibition spots against Streptococcus pyogenes (36.50 mm), Staphylococcus aureus (16.00 mm) and Pseudomonas aeruginosa (11.00 mm), corresponding to the TLC spots with Rf values 0.891, 0.87, 0.85 and 0.25, respectively. Component C showed inhibition spots against Streptococcus pyogenes (16.50 mm), Staphylococcus aureus (15.00 mm) and Pseudomonas aeruginosa (10.50 mm), corresponding to the TLC spots Rf values of 0.938, 0.44, 0.21 and 0.90, respectively. For the agar-well diffusion method, component A at 1 mg/ml inhibited Streptococcus pyogenes, Staphylococcus aureus and Pseudomonas aeruginosa growths with zones of inhibition 23.0, 19.5 and 17.50 mm, respectively. MIC and MBC of component A were 125, 250 and 250 and 250, 500 and 500 μg/ml, respectively. Component B at 1 mg/ml inhibited Streptococcus pyogenes, Staphylococcus aureus and Pseudomonas aeruginosa growth with zones of inhibition 30.0, 28.0 and 18.5 mm, respectively. MIC and MBC of the compound B were 31, 62 and 125 and 62, 125 and 250 μg/ml, respectively. Component C at 1 mg/ml inhibited Streptococcus pyogenes, Staphylococcus aureus and Pseudomonas aeruginosa growth with zones of inhibition 24.5, 20.5 and 17.0 mm, respectively. MIC and MBC of the component C were 62, 125 and 250 and 125, 250 and 500 μg/ml, respectively. This study confirmed that bioactive compounds of A. paniculatus root have antibacterial properties and support the use of this part of the plant as a traditional remedy for mouth and throat infections possibly caused by the test bacteria.

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