Epitaxial Seeded Growth of Rare-Earth Nanocrystals with Efficient 800 nm Near-Infrared to 1525 nm Short-Wavelength Infrared Downconversion Photoluminescence for In Vivo Bioimaging

2014 ◽  
Vol 53 (45) ◽  
pp. 12086-12090 ◽  
Author(s):  
Rui Wang ◽  
Xiaomin Li ◽  
Lei Zhou ◽  
Fan Zhang
Keyword(s):  
Rare Earth ◽  
Short Wavelength ◽  
Near Infrared ◽  
Seeded Growth

Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate)

Nanoscale ◽  
2011 ◽  
Vol 3 (9) ◽  
pp. 3705 ◽  
Author(s):  
Masao Kamimura ◽  
Naoki Kanayama ◽  
Kimikazu Tokuzen ◽  
Kohei Soga ◽  
Yukio Nagasaki
Keyword(s):  
Rare Earth ◽  
Near Infrared ◽  
Rare Earth Doped

scholarly journals Rapidly liver-clearable rare-earth core–shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Zhuxin Wei ◽  
Guangxin Duan ◽  
Baoxing Huang ◽  
Shanshan Qiu ◽  
Dandan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Earth ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Preoperative Imaging ◽  
Core Shell ◽  
High Background ◽  
Earth Core

Abstract Background Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200–400 nm) and visible light (Vis, 400–650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000–1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. Results Here, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core–shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. Conclusions The rationally designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision. Graphical abstract

scholarly journals Over-1000 nm Near-infrared Fluorescence and SPECT/CT Dual-modal in vivo Imaging Based on Rare-earth Doped Ceramic Nanophosphors

2016 ◽  
Vol 29 (4) ◽  
pp. 525-532 ◽  
Author(s):  
Masao Kamimura ◽  
Rie Saito ◽  
Hiroshi Hyodo ◽  
Kosuke Tsuji ◽  
Izumi O. Umeda ◽  
...  
Keyword(s):  
Rare Earth ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Rare Earth Doped

scholarly journals In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles

2019 ◽  
Vol 37 (11) ◽  
pp. 1322-1331 ◽  
Author(s):  
Yeteng Zhong ◽  
Zhuoran Ma ◽  
Feifei Wang ◽  
Xi Wang ◽  
Yijun Yang ◽  
...  
Keyword(s):  
Rare Earth ◽  
Molecular Imaging ◽  
Near Infrared ◽  
Rare Earth Nanoparticles

scholarly journals Rational Designed Rapid Liver Clearance Rare-earth Core-shell Nanoprobe for Dual-Modal Breast Cancer Imaging in the Second Near-Infrared Window

2021 ◽  
Author(s):  
Zhuxin Wei ◽  
Guangxin Duan ◽  
Baoxing Huang ◽  
Shanshan Qiu ◽  
Dandan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Earth ◽  
Near Infrared ◽  
Mri Contrast Agents ◽  
Preoperative Imaging ◽  
Core Shell ◽  
High Background ◽  
Earth Core

Abstract BackgroundFluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200-400 nm) and visible light (Vis, 400-650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000-1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the NIR-II fluorescence probes, especially for inorganic NPs, were hardly excreted from the reticuloendothelial system (RES), yielding the anonymous long-term circulatory safety issue. ResultsHere, we develop a facile strategy for the fabrication of Nd3+-doped rare-earth core-shell nanoparticles (Nd-RENPs), NaGdF4:5%Nd@NaLuF4, with strong emission in the NIR-II window. What’s more, the Nd-RENPs could be quickly eliminated from the hepatobiliary pathway, reducing the potential risk with the long-term retention in the RES. Further, the Nd-RENPs are successfully utilized for NIR-II in vivo imaging and magnetic resonance imaging (MRI) contrast agents, enabling the precise detection of breast cancer. ConclusionsThe rational designed Nd-RENPs nanoprobes manifest rapid-clearance property revealing the potential application toward the noninvasive preoperative imaging of tumor lesions and real-time intra-operative supervision.

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