scholarly journals A Dual-Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multiparametric Bioluminescence Imaging

2014 ◽  
Vol 53 (48) ◽  
pp. 13059-13063 ◽  
Author(s):  
Amit P. Jathoul ◽  
Helen Grounds ◽  
James C. Anderson ◽  
Martin A. Pule
Keyword(s):  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Dual Color ◽  
Firefly Luciferin

scholarly journals Berichtigung: A Dual-Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multiparametric Bioluminescence Imaging

2015 ◽  
Vol 127 (6) ◽  
pp. 1718-1718
Author(s):  
Amit P. Jathoul ◽  
Helen Grounds ◽  
James C. Anderson ◽  
Martin A. Pule
Keyword(s):  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Dual Color ◽  
Firefly Luciferin

scholarly journals A Dual-Color Far-Red to Near-Infrared Firefly Luciferin Analogue Designed for Multiparametric Bioluminescence Imaging

2014 ◽  
Vol 126 (48) ◽  
pp. 13275-13279 ◽  
Author(s):  
Amit P. Jathoul ◽  
Helen Grounds ◽  
James C. Anderson ◽  
Martin A. Pule
Keyword(s):  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Dual Color ◽  
Firefly Luciferin

scholarly journals Near-infrared bioluminescence imaging of two cell populations in living mice

2021 ◽  
Vol 2 (3) ◽  
pp. 100662
Author(s):  
Giorgia Zambito ◽  
Laura Mezzanotte
Keyword(s):  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Cell Populations

Near‐Infrared Bioluminescence Imaging with a through‐Bond Energy Transfer Cassette

ChemBioChem ◽  
2019 ◽  
Vol 20 (15) ◽  
pp. 1919-1923 ◽  
Author(s):  
Masahiro Abe ◽  
Ryo Nishihara ◽  
Yuma Ikeda ◽  
Takahiro Nakajima ◽  
Moritoshi Sato ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Bond Energy ◽  
Near Infrared ◽  
Bioluminescence Imaging

scholarly journals Sensitive Dual Color In Vivo Bioluminescence Imaging Using a New Red Codon Optimized Firefly Luciferase and a Green Click Beetle Luciferase

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e19277 ◽  
Author(s):  
Laura Mezzanotte ◽  
Ivo Que ◽  
Eric Kaijzel ◽  
Bruce Branchini ◽  
Aldo Roda ◽  
...  
Keyword(s):  
Bioluminescence Imaging ◽  
Firefly Luciferase ◽  
Dual Color ◽  
Click Beetle ◽  
In Vivo Bioluminescence Imaging

scholarly journals Development of near‐infrared firefly luciferin analogue reacted with wild‐type and mutant luciferases

Chirality ◽  
2020 ◽  
Vol 32 (7) ◽  
pp. 922-931 ◽  
Author(s):  
Nobuo Kitada ◽  
Ryohei Saito ◽  
Rika Obata ◽  
Satoshi Iwano ◽  
Kazuma Karube ◽  
...  
Keyword(s):  
Near Infrared ◽  
Wild Type ◽  
Firefly Luciferin

scholarly journals Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Mamoru Fukuchi ◽  
Ryohei Saito ◽  
Shojiro Maki ◽  
Nami Hagiwara ◽  
Yumena Nakajima ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Near Infrared ◽  
Bioluminescence Imaging ◽  
Neurological Diseases ◽  
Sensory Stimulation ◽  
Product Inhibition ◽  
Repeated Injection ◽  
Bdnf Expression ◽  
Non Invasive ◽  
Living Mouse

Abstract Altered levels of brain-derived neurotrophic factor (BDNF) have been reported in neurologically diseased human brains. Therefore, it is important to understand how the expression of BDNF is controlled under pathophysiological as well as physiological conditions. Here, we report a method to visualize changes in BDNF expression in the living mouse brain using bioluminescence imaging (BLI). We previously generated a novel transgenic mouse strain, Bdnf-Luciferase (Luc), to monitor changes in Bdnf expression; however, it was difficult to detect brain-derived signals in the strain using BLI with d-luciferin, probably because of incomplete substrate distribution and light penetration. We demonstrate that TokeOni, which uniformly distributes throughout the whole mouse body after systematic injection and produces a near-infrared bioluminescence light, was suitable for detecting signals from the brain of the Bdnf-Luc mouse. We clearly detected brain-derived bioluminescence signals that crossed the skin and skull after intraperitoneal injection of TokeOni. However, repeated BLI using TokeOni should be limited, because repeated injection of TokeOni on the same day reduced the bioluminescence signal, presumably by product inhibition. We successfully visualized kainic acid-induced Bdnf expression in the hippocampus and sensory stimulation-induced Bdnf expression in the visual cortex. Taken together, non-invasive near-infrared BLI using Bdnf-Luc mice with TokeOni allowed us to evaluate alterations in BDNF levels in the living mouse brain. This will enable better understanding of the involvement of BDNF expression in the pathogenesis and pathophysiology of neurological diseases.

Quantum yield improvement of red-light-emitting firefly luciferin analogues for in vivo bioluminescence imaging

Tetrahedron ◽  
2018 ◽  
Vol 74 (6) ◽  
pp. 652-660 ◽  
Author(s):  
Masahiro Kiyama ◽  
Satoshi Iwano ◽  
Satoshi Otsuka ◽  
Shijia W. Lu ◽  
Rika Obata ◽  
...  
Keyword(s):  
Quantum Yield ◽  
Bioluminescence Imaging ◽  
Red Light ◽  
Yield Improvement ◽  
Light Emitting ◽  
Firefly Luciferin ◽  
In Vivo Bioluminescence Imaging
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