Total Chemical Synthesis and Biological Activities of Glycosylated and Non-Glycosylated Forms of the Chemokines CCL1 and Ser-CCL1

2014 ◽  
pp. n/a-n/a ◽  
Author(s):  
Ryo Okamoto ◽  
Kalyaneswar Mandal ◽  
Morris Ling ◽  
Andrew D. Luster ◽  
Yasuhiro Kajihara ◽  
...  
Keyword(s):  
Chemical Synthesis ◽  
Biological Activities

Advances in Synthesis and Medicinal Applications of Compounds Derived from Phthalimide

2020 ◽  
Vol 17 (4) ◽  
pp. 252-270
Author(s):  
Marcel L. Almeida ◽  
Maria C.V.A. Oliveira ◽  
Ivan R. Pitta ◽  
Marina G.R. Pitta
Keyword(s):  
Chemical Synthesis ◽  
Biological Activities ◽  
Sedative Effects ◽  
Phthalimide Derivative ◽  
Anti Inflammatory

Phthalimide derivatives have been presenting several promising biological activities in the literature, such as anti-inflammatory, analgesic, antitumor, antimicrobial and anticonvulsant. The most well-known and studied phthalimide derivative (isoindoline-1,3-dione) is thalidomide: this compound initially presented important sedative effects, but it is now known that thalidomide has effectiveness against a wide variety of diseases, including inflammation and cancer. This review approaches some of the recent and efficient chemical synthesis pathways to obtain phthalimide analogues and also presents a summary of the main biological activities of these derivatives found in the literature. Therefore, this review describes the chemical and therapeutic aspects of phthalimide derivatives.

A Mini Review on the Chemical Synthesis of Resveratrol

2020 ◽  
Vol 17 (5) ◽  
pp. 546-558
Author(s):  
Hong Huang ◽  
Ruonan Liu ◽  
Wenhua Ou
Keyword(s):  
Cardiovascular Disease ◽  
Chemical Synthesis ◽  
Neurodegenerative Diseases ◽  
Biological Activities ◽  
Polyphenolic Compound ◽  
Chemical Methods

Resveratrol is a polyphenolic compound and has been shown to possess numerous biological activities, which could possibly be applied to the prevention and/or treatment of cancer, cardiovascular disease, and neurodegenerative diseases. This review summarizes the progress of different chemical methods in the preparation of resveratrol.

Oxysterols: Chemical synthesis, biosynthesis and biological activities

Lipids ◽  
1986 ◽  
Vol 21 (1) ◽  
pp. 27-30 ◽  
Author(s):  
Edward J. Parish ◽  
Venkata B. B. Nanduri ◽  
Herbert H. Kohl ◽  
Frederick R. Taylor
Keyword(s):  
Chemical Synthesis ◽  
Biological Activities

scholarly journals Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis

2020 ◽  
Vol 13 (3) ◽  
pp. 37 ◽  
Author(s):  
Xunan Zheng ◽  
Zhengning Ma ◽  
Dawei Zhang
Keyword(s):  
Drug Discovery ◽  
Chemical Synthesis ◽  
Small Molecules ◽  
Medicinal Chemistry ◽  
Biological Activities ◽  
Structural Features ◽  
Pharmaceutical Companies ◽  
Recent Developments ◽  
Van Leusen Reaction

Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and are widely researched and applied by pharmaceutical companies for drug discovery. The van Leusen reaction based on tosylmethylisocyanides (TosMICs) is one of the most appropriate strategies to synthetize imidazole-based medicinal molecules, which has been increasingly developed on account of its advantages. In this review, we summarize the recent developments of the chemical synthesis and bioactivity of imidazole-containing medicinal small molecules, utilizing the van Leusen imidazole synthesis from 1977.

scholarly journals Linear Triquinane Sesquiterpenoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2095 ◽  
Author(s):  
Yi Qiu ◽  
Wen-Jian Lan ◽  
Hou-Jin Li ◽  
Liu-Ping Chen
Keyword(s):  
Chemical Synthesis ◽  
Total Synthesis ◽  
Chemical Structure ◽  
Biological Activities ◽  
Structural Diversity ◽  
Structure Identification ◽  
Important Class ◽  
Soft Corals ◽  
Wide Range ◽  
New Challenges

Linear triquinane sesquiterpenoids represent an important class of natural products. Most of these compounds were isolated from fungi, sponges, and soft corals, and many of them displayed a wide range of biological activities. On account of their structural diversity and complexity, linear triquinane sesquiterpenoids present new challenges for chemical structure identification and total synthesis. 118 linear triquinane sesquiterpenoids were classified into 8 types, named types I–VIII, based on the carbon skeleton and the position of carbon substituents. Their isolation, structure elucidations, biological activities, and chemical synthesis were reviewed. This paper cited 102 articles from 1947 to 2018.

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