Chemical Synthesis of Aspidosperma Alkaloids Inspired by the Reverse of the Biosynthesis of the Rhazinilam Family of Natural Products

2012 ◽  
Vol 51 (37) ◽  
pp. 9288-9291 ◽  
Author(s):  
Lindsay McMurray ◽  
Elizabeth M. Beck ◽  
Matthew J. Gaunt
Keyword(s):  
Natural Products ◽  
Chemical Synthesis

Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools

2006 ◽  
pp. 51-89 ◽  
Author(s):  
Steven V. Ley ◽  
Ian R. Baxendale ◽  
Deborah A. Longbottom ◽  
Rebecca M. Myers
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
High Throughput

The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs

2020 ◽  
Author(s):  
Rishab N. Iyer ◽  
David Favela ◽  
Guoliang Zhang ◽  
David E. Olson
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Recent Advances

Few classes of natural products have inspired as many chemists and biologists as have the iboga alkaloids. This review covers recent advances in the biosynthesis and chemical synthesis of iboga alkaloids and their use as neurotherapeutics.

Natural products as a source of agrochemicals and leads for chemical synthesis

1993 ◽  
Vol 39 (2) ◽  
pp. 131-140 ◽  
Author(s):  
John B. Pillmoor ◽  
Kenneth Wright ◽  
Adrian S. Terry
Keyword(s):  
Natural Products ◽  
Chemical Synthesis

ChemInform Abstract: Polycyclic Xanthone Natural Products: Structure, Biological Activity and Chemical Synthesis

ChemInform ◽  
2013 ◽  
Vol 44 (19) ◽  
pp. no-no
Author(s):  
Dana K. Winter ◽  
David L. Sloman ◽  
Jr. Porco John A
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Chemical Synthesis

scholarly journals 16-Step Synthesis of the Isoryanodane Diterpene (+)-Perseanol

2019 ◽  
Author(s):  
Arthur Han ◽  
Yujia Tao ◽  
Sarah Reisman
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Building Blocks ◽  
Tetracyclic Core

(+)-Perseanol is an isoryanodane diterpene with potent antifeedant and insecticidal properties isolated from the tropical shrub <i>Persea indica</i>. Here we report the first chemical synthesis of (+)-perseanol, which proceeds in 16 steps from commercially available (<i>R</i>)-pulegone. The synthesis features a two-step annulation process that rapidly assembles the tetracyclic core from readily accessible cyclopentyl building blocks. This work demonstrates how convergent fragment coupling, when combined with strategic oxidation tactics, can enable the concise synthesis of complex and highly oxidized diterpene natural products. <br>

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