Guanidine-Ferroheme Coordination in the Mutant Protein Nitrophorin 4(L130R)

2012 ◽  
Vol 51 (18) ◽  
pp. 4470-4473 ◽  
Author(s):  
Chunmao He ◽  
Martin R. Fuchs ◽  
Hideaki Ogata ◽  
Markus Knipp
Keyword(s):  
Mutant Protein ◽  
Nitrophorin 4

scholarly journals Mosaic Pattern of H3 K27M-Mutant Protein Expression in a Diffuse Midline Glioma—A Diagnostic Dilemma for the Pathologist

2021 ◽  
Author(s):  
Deepti Narasimhaiah ◽  
Bejoy Thomas ◽  
Mathew Abraham ◽  
Rajalakshmi Poyuran
Keyword(s):  
Tumor Tissue ◽  
World Health ◽  
Mutant Protein ◽  
Histone Genes ◽  
Mosaic Pattern ◽  
Diagnostic Dilemma ◽  
Who Grade ◽  
Therapeutic Implications ◽  
Health Organization ◽  
Diffuse Midline Glioma

AbstractDiffuse midline glioma, H3 K27M-mutant, is a World Health Organization (WHO) grade IV glioma arising in pons, thalamus, and spinal cord. They show mutations resulting in replacement of lysine at position 27 by methionine (K27M) of histone genes, H3F3A, HIST1H3B, and HIST1H3C. The H3 K27M mutant protein is identified in tumor tissue by immunohistochemistry. As these mutations are clonal and homogeneous, the mutant protein is normally identified in all tumor cells. Here we report a case of diffuse midline glioma with mosaic pattern of expression of H3 K27M mutant protein and discuss the diagnostic and therapeutic implications of this unusual pattern.

scholarly journals Sir3p Domains Involved in the Initiation of Telomeric Silencing in Saccharomyces cerevisiae

Genetics ◽  
1998 ◽  
Vol 150 (3) ◽  
pp. 977-986 ◽  
Author(s):  
Yangsuk Park ◽  
John Hanish ◽  
Arthur J Lustig
Keyword(s):  
Amino Acids ◽  
Active Site ◽  
Fusion Proteins ◽  
Initiation Site ◽  
Negative Control ◽  
Model System ◽  
Mutant Protein ◽  
Regulatory Domain ◽  
C Terminus ◽  
Necessary And Sufficient

Abstract Previous studies from our laboratory have demonstrated that tethering of Sir3p at the subtelomeric/telomeric junction restores silencing in strains containing Rap1-17p, a mutant protein unable to recruit Sir3p. This tethered silencing assay serves as a model system for the early events that follow recruitment of silencing factors, a process we term initiation. A series of LexA fusion proteins in-frame with various Sir3p fragments were constructed and tested for their ability to support tethered silencing. Interestingly, a region comprising only the C-terminal 144 amino acids, termed the C-terminal domain (CTD), is both necessary and sufficient for restoration of silencing. Curiously, the LexA-Sir3N205 mutant protein overcomes the requirement for the CTD, possibly by unmasking a cryptic initiation site. A second domain spanning amino acids 481-835, termed the nonessential for initiation domain (NID), is dispensable for the Sir3p function in initiation, but is required for the recruitment of the Sir4p C terminus. In addition, in the absence of the N-terminal 481 amino acids, the NID negatively influences CTD activity. This suggests the presence of a third region, consisting of the N-terminal half (1-481) of Sir3p, termed the positive regulatory domain (PRD), which is required to initiate silencing in the presence of the NID. These data suggest that the CTD “active” site is under both positive and negative control mediated by multiple Sir3p domains.

Immunogenicity of the histidine-to-tyrosine staphylococcal enterotoxin B mutant protein in C3H/HeJ mice

Toxicon ◽  
2004 ◽  
Vol 43 (4) ◽  
pp. 433-438 ◽  
Author(s):  
Vladimir Savransky ◽  
Dmitriy Pinelis ◽  
Sergey Korolev ◽  
Boris Ionin ◽  
Konstantin Fegeding
Keyword(s):  
Staphylococcal Enterotoxin ◽  
Mutant Protein ◽  
Staphylococcal Enterotoxin B ◽  
Enterotoxin B

scholarly journals Effect of mutant protein of pharaonis halorhodopsin on its affinity for chloride

2000 ◽  
Vol 40 (supplement) ◽  
pp. S131
Author(s):  
T. Kanamori ◽  
M. Iwamoto ◽  
M. Sumi ◽  
N. Kamo
Keyword(s):  
Mutant Protein

scholarly journals An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells

2019 ◽  
Vol 160 ◽  
pp. 134-145 ◽  
Author(s):  
Mohammad B. Uddin ◽  
Kartik R. Roy ◽  
Salman B. Hosain ◽  
Sachin K. Khiste ◽  
Ronald A. Hill ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Mutant Protein
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