Near-Infrared-Fluorescence-Enhanced Molecular Imaging of Live Cells on Gold Substrates

2011 ◽  
Vol 50 (20) ◽  
pp. 4644-4648 ◽  
Author(s):  
Guosong Hong ◽  
Scott M. Tabakman ◽  
Kevin Welsher ◽  
Zhuo Chen ◽  
Joshua T. Robinson ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Live Cells ◽  
Near Infrared Fluorescence ◽  
Gold Substrates

Near-Infrared-Fluorescence-Enhanced Molecular Imaging of Live Cells on Gold Substrates

2011 ◽  
Vol 123 (20) ◽  
pp. 4740-4744 ◽  
Author(s):  
Guosong Hong ◽  
Scott M. Tabakman ◽  
Kevin Welsher ◽  
Zhuo Chen ◽  
Joshua T. Robinson ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Live Cells ◽  
Near Infrared Fluorescence ◽  
Gold Substrates

scholarly journals Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

2015 ◽  
Vol 112 (31) ◽  
pp. 9734-9739 ◽  
Author(s):  
Xueli Zhang ◽  
Yanli Tian ◽  
Can Zhang ◽  
Xiaoyu Tian ◽  
Alana W. Ross ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Imaging ◽  
Amyloid Beta ◽  
Near Infrared ◽  
Imaging Data ◽  
Curcumin Analog ◽  
Near Infrared Fluorescence ◽  
Brain Extraction ◽  
Monitoring Therapy

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring therapy of cancer and other diseases in preclinical studies; however, this technology has not been applied successfully to monitoring therapy for Alzheimer’s disease (AD). Although several NIRF probes for detecting amyloid beta (Aβ) species of AD have been reported, none of these probes has been used to monitor changes of Aβs during therapy. In this article, we demonstrated that CRANAD-3, a curcumin analog, is capable of detecting both soluble and insoluble Aβ species. In vivo imaging showed that the NIRF signal of CRANAD-3 from 4-mo-old transgenic AD (APP/PS1) mice was 2.29-fold higher than that from age-matched wild-type mice, indicating that CRANAD-3 is capable of detecting early molecular pathology. To verify the feasibility of CRANAD-3 for monitoring therapy, we first used the fast Aβ-lowering drug LY2811376, a well-characterized beta-amyloid cleaving enzyme-1 inhibitor, to treat APP/PS1 mice. Imaging data suggested that CRANAD-3 could monitor the decrease in Aβs after drug treatment. To validate the imaging capacity of CRANAD-3 further, we used it to monitor the therapeutic effect of CRANAD-17, a curcumin analog for inhibition of Aβ cross-linking. The imaging data indicated that the fluorescence signal in the CRANAD-17–treated group was significantly lower than that in the control group, and the result correlated with ELISA analysis of brain extraction and Aβ plaque counting. It was the first time, to our knowledge, that NIRF was used to monitor AD therapy, and we believe that our imaging technology has the potential to have a high impact on AD drug development.

scholarly journals P685In vivo near-infrared fluorescence (NIRF) molecular imaging of atherosclerosis

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M.-J. Bertrand ◽  
M. Abran ◽  
F. Maafi ◽  
D. Busseuil ◽  
N. Merlet ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence

Multiplexed cytokine detection on plasmonic gold substrates with enhanced near-infrared fluorescence

Nano Research ◽  
2012 ◽  
Vol 6 (2) ◽  
pp. 113-120 ◽  
Author(s):  
Bo Zhang ◽  
Jordan Price ◽  
Guosong Hong ◽  
Scott M. Tabakman ◽  
Hailiang Wang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Cytokine Detection ◽  
Gold Substrates
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