A Unified Approach for the Stereoselective Total Synthesis of Pyridone Alkaloids and Their Neuritogenic Activity

2011 ◽  
Vol 50 (18) ◽  
pp. 4222-4226 ◽  
Author(s):  
Henning Jacob Jessen ◽  
Andreas Schumacher ◽  
Travis Shaw ◽  
Andreas Pfaltz ◽  
Karl Gademann
Keyword(s):  
Total Synthesis ◽  
Unified Approach ◽  
Neuritogenic Activity

Unified approach to the sesquiterpenoids, lauranes and cyclolauranes: Total synthesis of (±)-isolaurene

2019 ◽  
Vol 60 (33) ◽  
pp. 150941 ◽  
Author(s):  
Sovan Niyogi ◽  
Arindam Khatua ◽  
Vishnumaya Bisai
Keyword(s):  
Total Synthesis ◽  
Unified Approach

scholarly journals A unified approach to the tedanolides: Total synthesis of (+)-13-deoxytedanolide

2004 ◽  
Vol 101 (33) ◽  
pp. 12042-12047 ◽  
Author(s):  
A. B. Smith ◽  
C. M. Adams ◽  
S. A. L. Barbosa ◽  
A. P. Degnan
Keyword(s):  
Total Synthesis ◽  
Unified Approach

scholarly journals Total Synthesis of Ritterazine B

2021 ◽  
Author(s):  
Yasuaki Nakayama ◽  
Michael Maser ◽  
Tatsuya Okita ◽  
Anton V. Dubrovskiy ◽  
Taryn L. Campbell ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Unified Approach ◽  
Common Precursor ◽  
Key Steps

<a></a>The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals, and late stage C–H oxidation to incorporate the C7<a></a><a>′</a> alcohol.<br>

The total synthesis of a ganglioside Hp-s1 analogue possessing neuritogenic activity by chemoselective activation glycosylation

2012 ◽  
Vol 10 (5) ◽  
pp. 931-934 ◽  
Author(s):  
Yow-Fu Tsai ◽  
Cheng-Hua Shih ◽  
Yu-Ting Su ◽  
Chun-Hsu Yao ◽  
Jang-Feng Lian ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Neuritogenic Activity

scholarly journals A Unified Approach for the Total Synthesis of cyclo ‐Archaeol, iso ‐Caldarchaeol, Caldarchaeol, and Mycoketide

2021 ◽  
Author(s):  
Ruben L. H. Andringa ◽  
Niels A. W. Kok ◽  
Arnold J. M. Driessen ◽  
Adriaan J. Minnaard
Keyword(s):  
Total Synthesis ◽  
Unified Approach

scholarly journals Total Synthesis of Ritterazine B

2021 ◽  
Author(s):  
Yasuaki Nakayama ◽  
Michael Maser ◽  
Tatsuya Okita ◽  
Anton V. Dubrovskiy ◽  
Taryn L. Campbell ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Unified Approach ◽  
Common Precursor ◽  
Key Steps

<a></a>The first total synthesis of the cytotoxic alkaloid ritterazine B is reported. The synthesis features a unified approach to both steroid subunits, employing a titanium-mediated propargylation reaction to achieve divergence from a common precursor. Other key steps include gold-catalyzed cycloisomerizations that install both spiroketals, and late stage C–H oxidation to incorporate the C7<a></a><a>′</a> alcohol.<br>

First total synthesis of ganglioside DSG-A possessing neuritogenic activity

2014 ◽  
Vol 12 (46) ◽  
pp. 9345-9349 ◽  
Author(s):  
Yu-Fa Wu ◽  
Yow-Fu Tsai ◽  
Jhe-Ruei Guo ◽  
Cheng-Ping Yu ◽  
Hui-Ming Yu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Synthetic Strategy ◽  
Neuritogenic Activity

The first total synthesis of ganglioside DSG-A (1) is achievedviachemoselective glycosylation and a [1 + 1 + 2] synthetic strategy.

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