Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

2009 ◽  
Vol 48 (32) ◽  
pp. 5853-5855 ◽  
Author(s):  
Sridhar Sreeramulu ◽  
Santosh Lakshmi Gande ◽  
Michael Göbel ◽  
Harald Schwalbe
Keyword(s):  
Molecular Mechanism ◽  
Protein Complex ◽  
Human Protein ◽  
Mechanism Of Inhibition

Molecular Mechanism of Inhibition of Nonclassical FGF-1 Export†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (47) ◽  
pp. 15472-15479 ◽  
Author(s):  
Dakshinamurthy Rajalingam ◽  
Thallapuranam Krishnaswamy S. Kumar ◽  
Raffaella Soldi ◽  
Irene Graziani ◽  
Igor Prudovsky ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Mechanism Of Inhibition

scholarly journals Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

2018 ◽  
Vol 62 (2) ◽  
pp. 987-992 ◽  
Author(s):  
Alexey Dementiev ◽  
Andrzej Joachimiak ◽  
Ha Nguyen ◽  
Alexei Gorelik ◽  
Katalin Illes ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Acid Ceramidase ◽  
Mechanism Of Inhibition

scholarly journals dTIS11 Protein-dependent Polysomal Deadenylation Is the Key Step in AU-rich Element-mediated mRNA Decay in Drosophila Cells

2012 ◽  
Vol 287 (42) ◽  
pp. 35527-35538 ◽  
Author(s):  
Caroline Vindry ◽  
Aurélien Lauwers ◽  
David Hutin ◽  
Romuald Soin ◽  
Corinne Wauquier ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Molecular Mechanism ◽  
Mrna Decay ◽  
Degradation Process ◽  
Mrna Degradation ◽  
Decay Process ◽  
Human Protein ◽  
P Bodies ◽  
Drosophila Cells ◽  
Degradation Intermediates

The destabilization of AU-rich element (ARE)-containing mRNAs mediated by proteins of the TIS11 family is conserved among eukaryotes including Drosophila. Previous studies have demonstrated that Tristetraprolin, a human protein of the TIS11 family, induces the degradation of ARE-containing mRNAs through a large variety of mechanisms including deadenylation, decapping, and P-body targeting. We have previously shown that the degradation of the mRNA encoding the antimicrobial peptide Cecropin A1 (CecA1) is controlled by the TIS11 protein (dTIS11) in Drosophila cells. In this study, we used CecA1 mRNA as a model to investigate the molecular mechanism of dTIS11-mediated mRNA decay. We observed that during the biphasic deadenylation and decay process of this mRNA, dTIS11 enhances deadenylation performed by the CCR4-CAF-NOT complex while the mRNA is still associated with ribosomes. Sequencing of mRNA degradation intermediates revealed that the complete deadenylation of the mRNA triggers its decapping and decay in both the 5′-3′ and the 3′-5′ directions. Contrary to the observations made for its mammalian homologs, overexpression of dTIS11 does not promote the localization of ARE-containing mRNAs in P-bodies but rather decreases the accumulation of CecA1 mRNA in these structures by enhancing the degradation process. Therefore, our results suggest that proteins of the TIS11 family may have acquired additional functions in the course of evolution from invertebrates to mammals.

Insights into the Molecular Mechanism of Inhibition and Drug Resistance for HIV-1 RT with Carbovir Triphosphate†

Biochemistry ◽  
2002 ◽  
Vol 41 (16) ◽  
pp. 5150-5162 ◽  
Author(s):  
Adrian S. Ray ◽  
Zhenjun Yang ◽  
Junxing Shi ◽  
Ann Hobbs ◽  
Raymond F. Schinazi ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Molecular Mechanism ◽  
Mechanism Of Inhibition ◽  
Hiv 1

scholarly journals The Molecular Mechanism of Inhibition of Newly Identified Inhibitors of Human MDR1 P‐Glycoprotein

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Pia D. Vogel ◽  
Fran K. Brewer ◽  
Courtney A. Follit ◽  
Isolina R. Rossi ◽  
John G. Wise
Keyword(s):  
Molecular Mechanism ◽  
P Glycoprotein ◽  
Mechanism Of Inhibition ◽  
Human Mdr1

Short-chain peptides as a promising class of chaperone-like anticataract agents: Molecular mechanism of inhibition of crystallin aggregation by pantethine

2010 ◽  
Vol 59 (1) ◽  
pp. 225-231 ◽  
Author(s):  
K. O. Muranov ◽  
A. K. Dizhevskaia ◽  
N. B. Poliansky ◽  
S. O. Dodonova ◽  
M. A. Ostrovsky
Keyword(s):  
Molecular Mechanism ◽  
Short Chain ◽  
Mechanism Of Inhibition
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