An Ugi Reaction in the Total Synthesis of (−)-Dysibetaine

2009 ◽  
Vol 48 (10) ◽  
pp. 1845-1848 ◽  
Author(s):  
Jerry Isaacson ◽  
Yoshihisa Kobayashi
Keyword(s):  
Total Synthesis ◽  
Ugi Reaction

An Ugi Reaction in the Total Synthesis of (−)-Dysibetaine

2009 ◽  
Vol 121 (10) ◽  
pp. 1877-1880 ◽  
Author(s):  
Jerry Isaacson ◽  
Yoshihisa Kobayashi
Keyword(s):  
Total Synthesis ◽  
Ugi Reaction

Total synthesis of exigurin: the Ugi reaction in a hypothetical biosynthesis of natural products

2020 ◽  
Vol 18 (4) ◽  
pp. 687-693 ◽  
Author(s):  
Seijiro Hosokawa ◽  
Keisuke Nakanishi ◽  
Yutaro Udagawa ◽  
Mitsutoshi Maeda ◽  
Seiya Sato ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Ugi Reaction ◽  
One Pot

Bioinspired U-5C-4CR employing (−)-10-epi-axisonitrile-3, formaldehyde and sarcosine in methanol showed remarkable efficiency to assemble multicomponents in a one-pot process, leading to the first total synthesis of exigurin.

Total Synthesis of Cordyheptapeptide A

Synlett ◽  
2017 ◽  
Vol 28 (15) ◽  
pp. 1971-1974 ◽  
Author(s):  
Daniel Rivera ◽  
Ludger Wessjohann ◽  
Alfredo Puentes ◽  
Ricardo Neves Filho
Keyword(s):  
Total Synthesis ◽  
Building Blocks ◽  
Ugi Reaction ◽  
Peptide Coupling ◽  
Main Building ◽  
Convergent Approach ◽  
Acyclic Precursor

The first total synthesis of cordyheptapeptide A is described. The synthesis is accomplished by a convergent approach featuring a combination of peptide coupling and the Ugi reaction for the preparation of the main building blocks and the acyclic precursor. The assembly of an N-methylated fragment by the Ugi reaction comprised the utilization of a convertible isonitrile followed by activation of the C-terminal amide. Two different macrocyclization sites were evaluated, proving greater efficacy the macrolactamization at the site Ile-Tyr, likely due of a more suitable conformational bias of the acyclic precursor having an internal β-turn centered at the N-Me-d-Phe-Pro moiety.

scholarly journals Total Synthesis of Ustiloxin D Utilizing an Ammonia–Ugi Reaction

2015 ◽  
Vol 80 (20) ◽  
pp. 9831-9837 ◽  
Author(s):  
Aaron L. Brown ◽  
Quentin I. Churches ◽  
Craig A. Hutton
Keyword(s):  
Total Synthesis ◽  
Ugi Reaction ◽  
Ustiloxin D

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product
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