Enantioselective Reduction of Ketones with “Designer Cells” at High Substrate Concentrations: Highly Efficient Access to Functionalized Optically Active Alcohols

2006 ◽  
Vol 45 (34) ◽  
pp. 5677-5681 ◽  
Author(s):  
Harald Gröger ◽  
Francoise Chamouleau ◽  
Nicolas Orologas ◽  
Claudia Rollmann ◽  
Karlheinz Drauz ◽  
...  
Keyword(s):  
Optically Active ◽  
High Substrate ◽  
Enantioselective Reduction ◽  
Highly Efficient ◽  
Efficient Access ◽  
Substrate Concentrations ◽  
Reduction Of Ketones

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo­methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

Synthesis ◽  
2020 ◽  
Author(s):  
Zhenjie Gan ◽  
Er-Qing Li ◽  
Ke Li ◽  
Hui Zhang
Keyword(s):  
Optically Active ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Efficient Access ◽  
Stereogenic Centers

AbstractA highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo­addition­ of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- and enantioselectivity, broad substrate scope and mild reaction conditions.

A highly efficient designer cell for enantioselective reduction of ketones

2015 ◽  
Vol 5 (1) ◽  
pp. 105-108 ◽  
Author(s):  
Gautam Srivastava ◽  
Mohan Pal ◽  
Suneet Kaur ◽  
Ravinder S. Jolly
Keyword(s):  
Cell Surface ◽  
Enzyme Activities ◽  
Glucose Dehydrogenase ◽  
Carbonyl Reductase ◽  
Enantioselective Reduction ◽  
Highly Efficient ◽  
Reduction Of Ketones

A highly efficient designer cell, surf-crs-gdh, which coexpresses carbonyl reductase (crs) and glucose dehydrogenase (gdh) on the cell surface, has been constructed and its enzyme activities were compared with those of the corresponding cell, cyto-crs-gdh, which coexpresses crs and gdh in cytoplasm.

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