Activation of Macrocyclic Enediynes by Transannular Cyclization

2005 ◽  
Vol 44 (1) ◽  
pp. 132-135 ◽  
Author(s):  
Amit Basak ◽  
Sandip Kumar Roy ◽  
Subrata Mandal
Keyword(s):  
Transannular Cyclization

Transannular Cyclization with Grignard Reagents: Facile Synthetic Routes to Oxaadamantane and Protoadamantane Derivatives

Synlett ◽  
2008 ◽  
Vol 2008 (3) ◽  
pp. 405-409 ◽  
Author(s):  
Kata Mlinarić-Majerski ◽  
Goran Kragol ◽  
Tatjana Ramljak
Keyword(s):  
Grignard Reagents ◽  
Transannular Cyclization ◽  
Synthetic Routes

ChemInform Abstract: Transannular Cyclization Products of a 7-Ethylidenebicyclo(3.3.2)decan- 3-one.

ChemInform ◽  
2010 ◽  
Vol 22 (33) ◽  
pp. no-no
Author(s):  
P. ANASTASIS ◽  
R. DUFFIN ◽  
V. MATASSA ◽  
K. H. OVERTON
Keyword(s):  
Transannular Cyclization

Transannular Cyclization

2008 ◽  
pp. 1
Author(s):  
F. Diederich ◽  
R. R. Tykwinski ◽  
M. B. Nielsen
Keyword(s):  
Transannular Cyclization

Ring-Closing Metathesis Approach to Cage Propellanes Containing Oxepane and Tetrahydrofuran Hybrid System

Synthesis ◽  
2017 ◽  
Vol 49 (24) ◽  
pp. 5339-5350 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Subba Cheekatla ◽  
Darshan Mhatre
Keyword(s):  
Claisen Rearrangement ◽  
Alder Reaction ◽  
Diels Alder ◽  
Ring Closing Metathesis ◽  
Cage Compounds ◽  
Transannular Cyclization ◽  
Diels Alder Reaction ◽  
Grignard Addition ◽  
Key Steps ◽  
First Time

The preparation of a variety of structurally interesting oxygenated cage compounds involving atom-economic processes such as Claisen rearrangement, Diels–Alder reaction, [2+2] photocycloaddition, and ring-closing metathesis (RCM) as key steps is reported. For the first time, oxepane ring system is introduced in cage framework using olefin metathesis as a key step. These cage systems assembled here are difficult to prepare by traditional methods. The synthetic sequence described here opens up new routes to higher order polycycles containing heteroatoms without the involvement of protecting groups. Transannular cyclization observed during Grignard addition and the RCM protocol used here may be applicable to generate unknown oxygenated cage systems.

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