Book Review: Medicinal Chemistry Research in India. By H. Singh, A. S. Chawla, and V. K. Kapoor

1987 ◽  
Vol 26 (2) ◽  
pp. 159-160
Author(s):  
Harald Burghard
Keyword(s):  
Medicinal Chemistry ◽  
Chemistry Research

A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions

2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Cross Coupling ◽  
Modular Approach ◽  
Coupling Reactions ◽  
One Pot ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Chemistry Research

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>

scholarly journals Excellence in Medicinal Chemistry Research from Japan

2020 ◽  
Vol 63 (17) ◽  
pp. 8877-8879
Author(s):  
Satoshi Shuto ◽  
Takayoshi Suzuki
Keyword(s):  
Medicinal Chemistry ◽  
Chemistry Research

A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

2020 ◽  
Vol 28 (23) ◽  
pp. 115813
Author(s):  
Nitin G. Ghatpande ◽  
Jagannath S. Jadhav ◽  
Rajshekhar V. Kaproormath ◽  
Mahmoud E. Soliman ◽  
Mahidansha M. Shaikh
Keyword(s):  
Medicinal Chemistry ◽  
Chemistry Research ◽  
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