Chemical Synthesis of Human Blood Group B Antigenic Determinant: Type 2 Tetrasaccharide

1979 ◽  
Vol 18 (6) ◽  
pp. 464-465 ◽  
Author(s):  
Marie-Louise Milat ◽  
Pierre Sinaÿ
Keyword(s):  
Chemical Synthesis ◽  
Blood Group ◽  
Human Blood ◽  
Antigenic Determinant ◽  
Human Blood Group ◽  
Group B

Chemical synthesis of the human blood-group P1-anti-genic determinant

1983 ◽  
Vol 122 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Paul-Henri Amvam Zollo ◽  
Jean-Claude Jacquinet ◽  
Pierre Sinaÿ
Keyword(s):  
Chemical Synthesis ◽  
Blood Group ◽  
Human Blood ◽  
Human Blood Group

scholarly journals A Single Point Mutation Reverses the Donor Specificity of Human Blood Group B-synthesizing Galactosyltransferase

2003 ◽  
Vol 278 (14) ◽  
pp. 12403-12405 ◽  
Author(s):  
Sandra L. Marcus ◽  
Robert Polakowski ◽  
Nina O. L. Seto ◽  
Eeva Leinala ◽  
Svetlana Borisova ◽  
...  
Keyword(s):  
Point Mutation ◽  
Blood Group ◽  
Human Blood ◽  
Single Point ◽  
Single Point Mutation ◽  
Human Blood Group ◽  
Group B

Molecular recognition XI. The synthesis of extensively deoxygenated derivatives of the H-type 2 human blood group determinant and their binding by an anti-H-type 2 monoclonal antibody and the lectin 1 of Ulexeuropaeus

1992 ◽  
Vol 70 (1) ◽  
pp. 254-271 ◽  
Author(s):  
Ulrike Spohr ◽  
Eugenia Paszkiewicz-Hnatiw ◽  
Naohiko Morishima ◽  
Raymond U. Lemieux
Keyword(s):  
Monoclonal Antibody ◽  
Molecular Recognition ◽  
Blood Group ◽  
Human Blood ◽  
Water Molecules ◽  
Hydroxyl Groups ◽  
Human Blood Group ◽  
Derivatives Of ◽  
Hydrogen Bonded

The relative potencies of a wide variety of deoxygenated derivatives of the methyl glycoside of α-L-Fuc-(1 → 2)-β-D-Gal-(1 → 4)- β-D-GlcNAc (the H-type 2 human blood group related trisaccharide) for the inhibition of the binding of an artificial H-type 2 antigen by the lectin I of Ulexeuropaeus confirmed the previous evidence that the key and productive interaction involves only the three hydroxyl groups of the α-L-fucose unit, the hydroxyl at the 3-position of the β-D-galactose residue, and the nonpolar groups in their immediate environment. Except for the acetamido group and the hydroxymethyl of the β-D-Gal unit, which stay in the aqueous phase, on complex formation the remaining three hydroxyl groups appear to come to reside at or near the periphery of the combining site since their replacement by hydrogen causes relatively small changes (< ± 1 kcal/mol) in the stability of the complex (ΔG0). Relatively much larger but compensating changes occur for the enthalpy and entropy terms, and these may arise primarily from the differences in the water structure about the periphery of the combining site and the oligosaccharide both prior to and after complexation. It is proposed that steric constraints lead to an ordered state of the water molecules hydrogen-bonded to the polar groups within the cleft formed by the key region of the amphiphilic combining site. Their release to form less ordered clusters of more strongly hydrogen-bonded water molecules in bulk solution would contribute importantly to the driving force for complexation. It is demonstrated that the surface used for the binding of H-type 2-OMe by a monoclonal anti-H antibody is virtually identical to that used by the Ulex lectin. Keywords: molecular recognition, H-type 2 blood group determinant and deoxygenated derivatives, lectin I of Ulexeuropaeus, anti-H-type 2 monoclonal antibody, enthalpy–entropy compensation.

A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant

Tetrahedron ◽  
2006 ◽  
Vol 62 (20) ◽  
pp. 4954-4978 ◽  
Author(s):  
Zhi-Guang Wang ◽  
J. David Warren ◽  
Vadim Y. Dudkin ◽  
Xufang Zhang ◽  
Ulrich Iserloh ◽  
...  
Keyword(s):  
Blood Group ◽  
Human Blood ◽  
Convergent Synthesis ◽  
Human Blood Group

scholarly journals Structural Effects of Naturally Occurring Human Blood Group B Galactosyltransferase Mutations Adjacent to the DXD Motif

2007 ◽  
Vol 282 (13) ◽  
pp. 9564-9570 ◽  
Author(s):  
Mattias Persson ◽  
James A. Letts ◽  
Bahram Hosseini-Maaf ◽  
Svetlana N. Borisova ◽  
Monica M. Palcic ◽  
...  
Keyword(s):  
Blood Group ◽  
Human Blood ◽  
Structural Effects ◽  
Human Blood Group ◽  
Naturally Occurring ◽  
Group B

NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments

2010 ◽  
Vol 27 (3) ◽  
pp. 349-358 ◽  
Author(s):  
Christoph Rademacher ◽  
Jens Landström ◽  
Nora Sindhuwinata ◽  
Monica M. Palcic ◽  
Göran Widmalm ◽  
...  
Keyword(s):  
Binding Site ◽  
Blood Group ◽  
Human Blood ◽  
Molecular Fragments ◽  
Human Blood Group ◽  
Group B
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