The Synthesis of Unusual Organic Molecules Using Cyclic Peroxides. New synthetic methods (3)

1974 ◽  
Vol 13 (10) ◽  
pp. 619-627 ◽  
Author(s):  
Waldemar Adam
Keyword(s):  
Organic Molecules ◽  
Synthetic Methods

An Integrated Console for Capsule-Based, Fully Automated Organic Synthesis

2019 ◽  
Author(s):  
Tuo Jiang ◽  
Samuele Bordi ◽  
Angus E. McMillan ◽  
Kuang-Yen Chen ◽  
Fumito Saito ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Operating System ◽  
Organic Synthesis ◽  
Reductive Amination ◽  
Organic Molecules ◽  
User Involvement ◽  
Synthetic Methods ◽  
Coupling Reactions ◽  
User Friendly ◽  
Complex Organic

The current laboratory-based practice of organic synthesis renders automation difficult, suffers from safety and environmental hazards, and hampers the implementation of artificial intelligence guided drug discovery. Using a combination of innovative reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules in a fully automated fashion. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two of the most desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

An Integrated Console for Capsule-Based, Fully Automated Organic Synthesis

2019 ◽  
Author(s):  
Tuo Jiang ◽  
Samuele Bordi ◽  
Angus E. McMillan ◽  
Kuang-Yen Chen ◽  
Fumito Saito ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Operating System ◽  
Organic Synthesis ◽  
Reductive Amination ◽  
Organic Molecules ◽  
User Involvement ◽  
Synthetic Methods ◽  
Coupling Reactions ◽  
User Friendly ◽  
Complex Organic

The current laboratory-based practice of organic synthesis renders automation difficult, suffers from safety and environmental hazards, and hampers the implementation of artificial intelligence guided drug discovery. Using a combination of innovative reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules in a fully automated fashion. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two of the most desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

Strategy for the Use of Molecular Oxygen in Organic Synthesis

Synlett ◽  
2020 ◽  
Author(s):  
Tsuyoshi Taniguchi
Keyword(s):  
Molecular Oxygen ◽  
Organic Synthesis ◽  
Electron Acceptor ◽  
Organic Molecules ◽  
Bond Formation ◽  
Reactive Species ◽  
Synthetic Methods ◽  
Mitsunobu Reaction ◽  
Iron Catalysts ◽  
Direct Quenching

Our recent studies on the development of new synthetic methods using molecular oxygen (O2), which is an environmentally friendly oxidant, are described in this Account. The character of O2 as an electron acceptor can be utilized for activation of simple organic molecules to generate reactive species. Such reactive species are applicable to advanced molecular transformation, such as C–C and C–X (X = heteroatom) bond formation, functionalization of inactivated C(sp3)–H, and catalytic Mitsunobu reaction, by avoiding direct quenching of the reactive species by O2.1 Introduction2 Reactions with Iron Catalysts and Oxygen2.1 Reactions Using Redox Hydration of Alkenes2.2 Reactions Using Oxidation of Heteroatoms3 Reactions with tert-Butyl Nitrite and Oxygen4 Conclusion

scholarly journals Organic electrosynthesis: from academia to industry

2020 ◽  
Vol 5 (6) ◽  
pp. 977-990 ◽  
Author(s):  
Matthew C. Leech ◽  
Anthony D. Garcia ◽  
Alessia Petti ◽  
Adrian P. Dobbs ◽  
Kevin Lam
Keyword(s):  
Organic Molecules ◽  
Synthetic Methods ◽  
Small Organic Molecules ◽  
Cost Efficient

The growing impetus to develop greener and more cost-efficient synthetic methods has prompted chemists to look for new ways to activate small organic molecules. In this review, we cover the most recent industrial developments in electrosynthesis.

Organocatalytic Synthesis of Heterocycles: A Brief Overview Covering Recent Aspects

2020 ◽  
Vol 07 ◽  
Author(s):  
Rajib Sarkar ◽  
Chhanda Mukhopadhyay
Keyword(s):  
Organic Synthesis ◽  
Organic Molecules ◽  
Synthetic Methods ◽  
Environmentally Benign ◽  
Reaction Conditions ◽  
Small Organic Molecules ◽  
Heterocycle Synthesis ◽  
The Past ◽  
Metal Catalyzed ◽  
Atom Bond

Abstract:: The use of small organic molecules as organocatalysts in organic synthesis has intensely studied over the past decade. In this emerging field, considerable study has led to the introduction of various efficient organocatalyzed synthetic methods of carbon-carbon and carbon-hetero atom bond formations. The use of these organocatalysts also emerged environmentally benign reaction conditions compared to the metal catalyzed transformations. In this review, we make a special attention on the most recent organocatalytic protocols reported for the synthesis of heterocycles. The works have been outlined by depending on the organocatalysts used as (i) nitrogen based molecules as organocatalyst, (ii) NHCs as organocatalyst, and (iii) phosphorus based molecules as organocatalyst. The discussion intends to reveal the scope as well as vitality of organocatalysis in the area of heterocycle synthesis.

scholarly journals Photoredox catalysis by [Ru(bpy)3]2+ to trigger transformations of organic molecules. Organic synthesis using visible-light photocatalysis and its 20th century roots

2011 ◽  
Vol 76 (7) ◽  
pp. 859-917 ◽  
Author(s):  
Filip Teplý
Keyword(s):  
Visible Light ◽  
Organic Synthesis ◽  
Organic Molecules ◽  
Recent Literature ◽  
Synthetic Methods ◽  
Bond Breaking ◽  
Materials Chemistry ◽  
Photoredox Catalysis ◽  
Contemporary Work ◽  
Developing Area

Reactions triggered by light constitute a treasure trove of unique synthetic methods that are available to chemists. Photoinduced redox processes using visible light in conjunction with sensitizing dyes offer a great variety of catalytic transformations useful in the realm of organic synthesis. The recent literature amply shows that this preparative toolbox is expanding substantially. This review discusses historical and contemporary work in the area of photoredox catalysis with [Ru(bpy)3]2+. Elegant examples from the most recent literature document the importance of this fast developing area of research. The photoredox chemistry has also emerged as a promising bond-making and bond-breaking tool for chemical biology and materials chemistry. A review with 96 references.

scholarly journals Efficient synthetic methods for the installation of boron–nitrogen bonds in conjugated organic molecules

2016 ◽  
Vol 45 (14) ◽  
pp. 5920-5924 ◽  
Author(s):  
Matthew M. Morgan ◽  
Warren E. Piers
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Organic Molecules ◽  
Synthetic Methods ◽  
Conjugated Organic Molecules ◽  
Polycyclic Aromatic ◽  
Device Applications ◽  
Nitrogen Bonds ◽  
Boron Nitrogen

New synthetic methods for preparing gram quantities BN analogs of polycyclic aromatic hydrocarbons are highlighted. Such methods are key to proper evaluation of these materials in device applications.

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