Direct Access to Primary Amines from Alkenes by Selective Metal‐Free Hydroamination

2021 ◽  
Vol 133 (18) ◽  
pp. 9963-9968
Author(s):  
Yi‐Dan Du ◽  
Bi‐Hong Chen ◽  
Wei Shu
Keyword(s):  
Direct Access ◽  
Primary Amines ◽  
Metal Free

scholarly journals Metal-Free Air Oxidation in a Convenient Cascade Approach for the Access to Isoquinoline-1,3,4(2H)-triones

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2177
Author(s):  
Antonia Di Mola ◽  
Consiglia Tedesco ◽  
Antonio Massa
Keyword(s):  
Heterocyclic Compounds ◽  
Aromatic Ketone ◽  
Primary Amines ◽  
Cascade Process ◽  
Staudinger Reaction ◽  
Caspase Inhibitor ◽  
Air Oxidation ◽  
Metal Free ◽  
Free Air

Herein we describe a very useful application of the readily available trifunctional aromatic ketone methyl-2-(2-bromoacetyl)benzoate in reactions with primary amines. An unexpected in situ air oxidation that follows a cascade process allowed the access to a series of isoquinoline-1,3,4(2H)-triones, a class of heterocyclic compounds of great interest containing an oxygen-rich heterocyclic scaffold. A modification of the original protocol, utilizing a Staudinger reaction in the presence of trimethylphosphine, was necessary for the synthesis of Caspase inhibitor trione with free NH group.

Synthesis of 2-Aryl-5-alkyl-fulleropyrrolidines: Metal-Free-Mediated Reaction of [60]Fullerene with Aromatic Aldehydes and Inactive Primary Amines

2017 ◽  
Vol 82 (16) ◽  
pp. 8617-8627 ◽  
Author(s):  
Meng Zhang ◽  
Hui-Juan Wang ◽  
Fa-Bao Li ◽  
Xin-Xin Zhong ◽  
Yong-Shun Huang ◽  
...  
Keyword(s):  
Aromatic Aldehydes ◽  
Primary Amines ◽  
Metal Free

A general metal-free route towards the synthesis of 1,2,3-triazoles from readily available primary amines and ketones

2016 ◽  
Vol 52 (14) ◽  
pp. 2885-2888 ◽  
Author(s):  
Joice Thomas ◽  
Sampad Jana ◽  
Jubi John ◽  
Sandra Liekens ◽  
Wim Dehaen
Keyword(s):  
Natural Products ◽  
Primary Amines ◽  
Metal Free ◽  
Amino Esters

A metal-free route towards different 1,2,3-triazole heterocycles was accomplished by using inexpensive and readily available ketones and primary amines. This reaction is very general and was extended to functionalize different amino esters, dendrimers and natural products.

scholarly journals Metal-Free Oxidative Dimerization of Dithiocarbamates: Direct Access to 3,5-Bis-mercapto-1,2,4-thiadiazoles

SynOpen ◽  
2017 ◽  
Vol 01 (01) ◽  
pp. 0138-0142 ◽  
Author(s):  
Azim Halimehjani ◽  
Yazdanbakhsh Nosood ◽  
Shaghayegh Didaran ◽  
Fezzeh Aryanasab
Keyword(s):  
Periodic Acid ◽  
Reaction Times ◽  
Direct Access ◽  
Oxidative Dimerization ◽  
Metal Free

A facile and efficient protocol for the synthesis of 3,5-bis-mercapto-1,2,4-thiadiazoles by the oxidative dimerization of S-alkyl dithiocarbamates using periodic acid as an inexpensive and commercially available oxidant is reported. High to excellent yields and short reaction times are the main advantages of this procedure.

ChemInform Abstract: A Metal-Free Oxidative Amination of Benzoxazoles with Primary Amines and Ammonia.

ChemInform ◽  
2012 ◽  
Vol 43 (17) ◽  
pp. no-no
Author(s):  
Ulrich Kloeckner ◽  
Nicole M. Weckenmann ◽  
Boris J. Nachtsheim
Keyword(s):  
Primary Amines ◽  
Oxidative Amination ◽  
Metal Free
Sign in / Sign up

Export Citation Format

Share Document