Concentration‐Dependent Subcellular Distribution of Ultrasmall Near‐Infrared‐Emitting Gold Nanoparticles

2020 ◽  
Author(s):  
Lingshan Gong ◽  
Kui He ◽  
Jinbin Liu
Keyword(s):  
Gold Nanoparticles ◽  
Subcellular Distribution ◽  
Near Infrared

Green and facile preparation and dual-enhancement cytotoxicity of eupatilin loaded on hollow gold nanoparticles under near-infrared light

2021 ◽  
Author(s):  
Yi-wei Sun ◽  
Hui Liang ◽  
Kun-qi Zong ◽  
Xin Che ◽  
Da-li Meng
Keyword(s):  
Gold Nanoparticles ◽  
Natural Products ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Hollow Gold Nanoparticles ◽  
Facile Preparation ◽  
Gold Nanomaterials ◽  
Anti Tumor Activity ◽  
Targeted Release

Using NIR irradiation, gold nanomaterials loaded with natural products can achieve targeted release as well as better anti-tumor activity.

scholarly journals Computed Tomography Imaging Agent Based on Gold Nanoparticles for Internal Iliac Artery Embolization after Endovascular Abdominal Aortic Repair and CCN3 Protection Mechanism

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Siying Pei ◽  
Yao Sun ◽  
Dongxu Fan ◽  
Shuhua Deng ◽  
Haoran Mei ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Near Infrared ◽  
Infrared Region ◽  
Fluorescent Properties ◽  
Protection Mechanism ◽  
Abdominal Aortic ◽  
Infrared Rays ◽  
Growth Method ◽  
Internal Iliac ◽  
Endovascular Abdominal Aortic Repair

Abdominal aortic aneurysm is more stressful and has more complications in many diseases. During treatment and repair, arteriosclerosis, abdominal congestion deposition, and abdominal swelling cannot be eliminated. In this paper, we used the seed growth method to obtain gold nanoparticles (AuNPs) with good morphology and dispersion. The AuNPs of larger aspect ratio synthesized in this experiment moved their longitudinal plasmon resonance absorption peak to the near-infrared region, which provided suitable materials for subsequent experiments and laid the foundation for the photothermal therapy of tumors. Experiments show that near-infrared rays can penetrate into deep tissues to overcome the shortcomings that visible light cannot penetrate abdominal aorta well. AuNPs absorb near-infrared rays, thereby generating heat energy to achieve the purpose of treating tumors. In addition, AuNPs also have fluorescent properties, combined with other forms of imaging methods, to achieve the purpose of multimodal imaging, and improve the diagnostic accuracy of studying the protection mechanism of the nephroblastoma overexpressed (NOV or CCN3) gene.

scholarly journals Experimental setup for light-to-heat NIR conversion measurements of gold nano-particles’ solutions

2018 ◽  
Vol 5 (2) ◽  
pp. 38-47
Author(s):  
Nikolay Uzunov ◽  
Michele Bello ◽  
Laura Melendez-Alafort ◽  
Laura De Nardo
Keyword(s):  
Gold Nanoparticles ◽  
Near Infrared ◽  
Laser System ◽  
Fluorescence Emission ◽  
Ambient Air ◽  
Infrared Region ◽  
Nano Particles ◽  
Fixed Temperature ◽  
Electronic Temperature ◽  
Cuvette Holder

Abstract In recent years, there is a constantly increasing interest in the application of nanoparticles for cancer diagnosis and cancer therapy. In this respect, the most promising nano-objects at present are the gold nanoparticles. A very convenient and powerful property of these objects is their ability to increase their temperature under electro-magnetic irradiation with certain wavelength. In our research we have directed our efforts toward particular nano-objects specifically sensitive to electromagnetic radiation in the near-infrared region (NIR). In order to study the photothermic properties of the solutions of gold nanoparticles in the NIR we constructed a specific electronic setup consisting of a laser system with interchangeable laser diodes with different wavelength NIR light, a thermally-insulated cuvette-holder compartment with temperature measuring probes and a NIR spectrometer to control the stimulated fluorescence emission of the nanoparticles’ solutions. The temperature measurement compartment with the thermal-insulated cuvette holder was designed to maintain the solutions’ temperature at a fixed value right before the moment of laser irradiation. To maintain the measurement setup at a fixed temperature before the irradiation we used a thermal stabilized system based on two Peltier cells with electronic temperature control. The temperatures of the ambient air and the temperature of the cuvette walls were continuously measured in order to make corrections about the temperature dissipation during the irradiation.

scholarly journals Front Cover: Near-Infrared Photoluminescence from Small Copper, Silver, and Gold Nanoparticles (ChemNanoMat 3/2018)

ChemNanoMat ◽  
2018 ◽  
Vol 4 (3) ◽  
pp. 243-243
Author(s):  
Christopher M. Andolina ◽  
Scott E. Crawford ◽  
Ashley M. Smith ◽  
Kathryn A. Johnston ◽  
Patrick J. Straney ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Near Infrared ◽  
Front Cover ◽  
Silver And Gold Nanoparticles

Atom transfer radical-polymerized cationic shells on gold nanoparticles for near infrared-triggered photodynamic therapy of tumor-bearing animals

2021 ◽  
Author(s):  
Oanh-Vu Pham-Nguyen ◽  
Ju Won Lee ◽  
Sila Jin ◽  
Yeonju Park ◽  
Song Rae Kim ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Near Infrared ◽  
Atom Transfer ◽  
Ethyl Methacrylate ◽  
Tumor Bearing

Gold nanoparticles (AuNPs) were surface-engineered with a cationic corona to enhance the incorporation of photosensitizers for photodynamic therapy. The cationic corona composed of poly(2-(dimethylamino)ethyl methacrylate) was atom transfer radical-polymerized on...

Triggered drug release from hybrid thermoresponsive nanoparticles using near infrared light

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 219-234 ◽  
Author(s):  
Isabel Ortiz de Solorzano ◽  
Martin Prieto ◽  
Gracia Mendoza ◽  
Victor Sebastian ◽  
Manuel Arruebo
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Chemical Characterization ◽  
Infrared Light ◽  
Galvanic Replacement ◽  
Heating Efficiency ◽  
Hollow Gold Nanoparticles

Aim: Developing hybrid poly(N-isopropylacrylamide)-based nanogels decorated with plasmonic hollow gold nanoparticles for on-demand drug delivery and their physico-chemical characterization, bupivacaine loading and release ability upon light irradiation, and in vitro cell viability. Materials & methods: Hollow gold nanoparticles were prepared by galvanic replacement reaction; poly(N-isopropylacrylamide)-based nanogels were synthesized via precipitation polymerization and their electrostatic coupling was accomplished using poly(allylamine hydrochloride) as cationic polyelectrolyte linker. Results & conclusion: Colloidal stability of the resulted hybrid nanovectors was demonstrated under physiological conditions together with their fast response and excellent heating efficiency after light stimulation, indicating their potential use as triggered drug-delivery vectors. Moreover, their influence on cell metabolism and cell cycle under subcytotoxic doses were studied showing excellent cytocompatibility.

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