scholarly journals Redox Stability Controls the Cellular Uptake and Activity of Ruthenium‐Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU)

2020 ◽  
Vol 132 (16) ◽  
pp. 6544-6553 ◽  
Author(s):  
Joshua J. Woods ◽  
James Lovett ◽  
Barry Lai ◽  
Hugh H. Harris ◽  
Justin J. Wilson
Keyword(s):  
Cellular Uptake ◽  
Mitochondrial Calcium ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter ◽  
Redox Stability

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 288-LB
Author(s):  
JI EUN LEE ◽  
LEIGH GOEDEKE ◽  
YE ZHANG ◽  
RACHEL J. PERRY ◽  
RUSSELL GOODMAN ◽  
...  
Keyword(s):  
Mitochondrial Metabolism ◽  
Mitochondrial Calcium ◽  
Hepatic Gluconeogenesis ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter

Cobalt amine complexes and Ru265 interact with the DIME region of the mitochondrial calcium uniporter

2021 ◽  
Author(s):  
Joshua J. Woods ◽  
Madison X. Rodriguez ◽  
Chen-Wei Tsai ◽  
Ming-Feng Tsai ◽  
Justin J. Wilson
Keyword(s):  
Mechanisms Of Action ◽  
Mitochondrial Calcium ◽  
Mitochondrial Calcium Uniporter ◽  
Amine Complexes ◽  
Calcium Uniporter

The MCU-inhibitory properties and mechanisms of action of Co3+ amine complexes and Ru265 are described.

scholarly journals Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter

Cell Reports ◽  
2021 ◽  
Vol 35 (12) ◽  
pp. 109275
Author(s):  
Agnese De Mario ◽  
Anna Tosatto ◽  
Julia Marie Hill ◽  
Janos Kriston-Vizi ◽  
Robin Ketteler ◽  
...  
Keyword(s):  
Mitochondrial Calcium ◽  
Functional Validation ◽  
Mitochondrial Calcium Uniporter ◽  
Calcium Uniporter
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