scholarly journals EPR Distance Measurements on Long Non‐coding RNAs Empowered by Genetic Alphabet Expansion Transcription

2020 ◽  
Vol 132 (20) ◽  
pp. 7965-7970 ◽  
Author(s):  
Christof Domnick ◽  
Frank Eggert ◽  
Christine Wuebben ◽  
Lisa Bornewasser ◽  
Gregor Hagelueken ◽  
...  
Keyword(s):  
Distance Measurements ◽  
Non Coding Rnas ◽  
Genetic Alphabet

scholarly journals EPR Distance Measurements on Long Non‐coding RNAs Empowered by Genetic Alphabet Expansion Transcription

2020 ◽  
Vol 59 (20) ◽  
pp. 7891-7896 ◽  
Author(s):  
Christof Domnick ◽  
Frank Eggert ◽  
Christine Wuebben ◽  
Lisa Bornewasser ◽  
Gregor Hagelueken ◽  
...  
Keyword(s):  
Distance Measurements ◽  
Non Coding Rnas ◽  
Genetic Alphabet

Long Non-Coding RNAs Are Commonly Deregulated in Hodgkin Lymphoma

2014 ◽  
Vol 226 (02) ◽  
Author(s):  
A van den Berg ◽  
M Tayari ◽  
G Kortman ◽  
J Sietzema ◽  
D de Jong ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Non Coding Rnas

MicroRNAs and their role in hematological malignant diseases

2012 ◽  
Vol 153 (52) ◽  
pp. 2051-2059 ◽  
Author(s):  
Zsuzsanna Gaál ◽  
Éva Oláh
Keyword(s):  
Target Genes ◽  
Lymphoblastic Leukemia ◽  
Cancer Tissue ◽  
Altered Expression ◽  
Diagnosis And Prognosis ◽  
Oncologic Patients ◽  
Different Types ◽  
Non Coding Rnas ◽  
Success Of Treatment ◽  
Posttranscriptional Level

MicroRNAs are a class of small non-coding RNAs regulating gene expression at posttranscriptional level. Their target genes include numerous regulators of cell cycle, cell proliferation as well as apoptosis. Therefore, they are implicated in the initiation and progression of cancer, tissue invasion and metastasis formation as well. MicroRNA profiles supply much information about both the origin and the differentiation state of tumours. MicroRNAs also have a key role during haemopoiesis. An altered expression level of those have often been observed in different types of leukemia. There are successful attempts to apply microRNAs in the diagnosis and prognosis of acute lymphoblastic leukemia and acute myeloid leukemia. Measurement of the expression levels may help to predict the success of treatment with different kinds of chemotherapeutic drugs. MicroRNAs are also regarded as promising therapeutic targets, and can contribute to a more personalized therapeutic approach in haemato-oncologic patients. Orv. Hetil., 2012, 153, 2051–2059.

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