Sequence‐Dependent Stereodivergent Allylic Alkylation/Fluorination of Acyclic Ketones

2019 ◽  
Vol 132 (5) ◽  
pp. 2055-2059 ◽  
Author(s):  
Xi‐Jia Liu ◽  
Shicheng Jin ◽  
Wen‐Yun Zhang ◽  
Qiang‐Qiang Liu ◽  
Chao Zheng ◽  
...  
Keyword(s):  
Allylic Alkylation ◽  
Sequence Dependent ◽  
Acyclic Ketones

Sequence‐Dependent Stereodivergent Allylic Alkylation/Fluorination of Acyclic Ketones

2020 ◽  
Vol 59 (5) ◽  
pp. 2039-2043 ◽  
Author(s):  
Xi‐Jia Liu ◽  
Shicheng Jin ◽  
Wen‐Yun Zhang ◽  
Qiang‐Qiang Liu ◽  
Chao Zheng ◽  
...  
Keyword(s):  
Allylic Alkylation ◽  
Sequence Dependent ◽  
Acyclic Ketones

Palladium-catalyzed asymmetric allylic alkylation of acyclic ketones for synthesis of 2,2-disubsituted pyrrolidine derivatives

2017 ◽  
Vol 58 (14) ◽  
pp. 1399-1402 ◽  
Author(s):  
Wen-Fang Lian ◽  
Cui-Cui Wang ◽  
Huai-Ping Kang ◽  
Hai-Ling Li ◽  
Juan Feng ◽  
...  
Keyword(s):  
Allylic Alkylation ◽  
Asymmetric Allylic Alkylation ◽  
Palladium Catalyzed ◽  
Acyclic Ketones

Ni(0)-Catalyzed α-Allylic Alkylation of Regular Ketones with 1,3-Dienes under pH and Redox-neutral Conditions

2019 ◽  
Author(s):  
Tiantian Chen ◽  
Yang Yang ◽  
Liyu Xie ◽  
Haijian Yang ◽  
Guangbin Dong ◽  
...  
Keyword(s):  
Oxidative Addition ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Dual Role ◽  
Allylic Alkylation ◽  
Cross Coupling Reaction ◽  
Neutral Conditions

<p>We report a Ni(0)-catalyzed cross coupling reaction between simple ketones and 1,3-dienes. A variety of a-allylic alkylation products were formed in an 1,2-addition manner with excellent regioselectivity. Water was found to significantly accelerate this transformation. A HO-Ni-H species generated from oxidative addition of Ni(0) to H<sub>2</sub>O is proposed to play a “dual role” in activating both the ketone and the diene substrate.</p>

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