Untargeted Tumor Metabolomics with Liquid Chromatography–Surface‐Enhanced Raman Spectroscopy

2020 ◽  
Vol 132 (9) ◽  
pp. 3467-3471
Author(s):  
Lifu Xiao ◽  
Chuanqi Wang ◽  
Chen Dai ◽  
Laurie E. Littlepage ◽  
Jun Li ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Liquid Chromatography ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Untargeted Tumor Metabolomics with Liquid Chromatography–Surface‐Enhanced Raman Spectroscopy

2020 ◽  
Vol 59 (9) ◽  
pp. 3439-3443 ◽  
Author(s):  
Lifu Xiao ◽  
Chuanqi Wang ◽  
Chen Dai ◽  
Laurie E. Littlepage ◽  
Jun Li ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Liquid Chromatography ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Quantitative online sheath-flow surface enhanced Raman spectroscopy detection for liquid chromatography

The Analyst ◽  
2016 ◽  
Vol 141 (12) ◽  
pp. 3630-3635 ◽  
Author(s):  
Anh Nguyen ◽  
Zachary D. Schultz
Keyword(s):  
Raman Spectroscopy ◽  
Liquid Chromatography ◽  
Small Molecules ◽  
Surface Enhanced Raman Spectroscopy ◽  
Online Detection ◽  
Sheath Flow ◽  
Flow Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Detection And Quantification

Sheath-flow surface-enhanced Raman spectroscopy (SERS) was used for online detection and quantification of small molecules separated by liquid chromatography.

scholarly journals A Review of Detection of Antibiotic Residues in Food by Surface-Enhanced Raman Spectroscopy

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Jun-Fa Liang ◽  
Cheng Peng ◽  
Peiyu Li ◽  
Qiu-Xiong Ye ◽  
Yu Wang ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Liquid Chromatography ◽  
Surface Enhanced Raman Spectroscopy ◽  
Antibiotic Residues ◽  
Basic Principles ◽  
Promising Alternative ◽  
Residue Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Analytical Approaches

Antibiotics, as veterinary drugs, have made extremely important contributions to disease prevention and treatment in the animal breeding industry. However, the accumulation of antibiotics in animal food due to their overuse during animal feeding is a frequent occurrence, which in turn would cause serious harm to public health when they are consumed by humans. Antibiotic residues in food have become one of the central issues in global food safety. As a safety measure, rapid and effective analytical approaches for detecting these residues must be implemented to prevent contaminated products from reaching the consumers. Traditional analytical methods, such as liquid chromatography, liquid chromatography mass spectrometry, and capillary electrophoresis, involve time-consuming sample preparation and complicated operation and require expensive instrumentation. By comparison, surface-enhanced Raman spectroscopy (SERS) has excellent sensitivity and remarkably enhanced target recognition. Thus, SERS has become a promising alternative analytical method for detecting antibiotic residues, as it can provide an ultrasensitive fingerprint spectrum for the rapid and noninvasive detection of trace analytes. In this study, we comprehensively review the recent progress and advances that have been achieved in the use of SERS in antibiotic residue detection. We introduce and discuss the basic principles of SERS. We then present the prospects and challenges in the use of SERS in the detection of antibiotics in food. Finally, we summarize and discuss the current problems and future trends in the detection of antibiotics in food.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

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