Aryl Sulfonium Salts for Site‐Selective Late‐Stage Trifluoromethylation

2019 ◽  
Vol 131 (41) ◽  
pp. 14757-14761 ◽  
Author(s):  
Fei Ye ◽  
Florian Berger ◽  
Hao Jia ◽  
Joseph Ford ◽  
Alan Wortman ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

scholarly journals Aryl Sulfonium Salts for Site‐Selective Late‐Stage Trifluoromethylation

2019 ◽  
Vol 58 (41) ◽  
pp. 14615-14619 ◽  
Author(s):  
Fei Ye ◽  
Florian Berger ◽  
Hao Jia ◽  
Joseph Ford ◽  
Alan Wortman ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

scholarly journals Site‐Selective Late‐Stage Aromatic [ 18 F]Fluorination via Aryl Sulfonium Salts

2019 ◽  
Vol 132 (5) ◽  
pp. 1972-1976 ◽  
Author(s):  
Peng Xu ◽  
Da Zhao ◽  
Florian Berger ◽  
Aboubakr Hamad ◽  
Jens Rickmeier ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

C–N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts

2019 ◽  
Vol 141 (34) ◽  
pp. 13346-13351 ◽  
Author(s):  
Pascal S. Engl ◽  
Andreas P. Häring ◽  
Florian Berger ◽  
Georg Berger ◽  
Alberto Pérez-Bitrián ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

scholarly journals Addition to “C–N Cross-Couplings for Site-Selective Late-Stage Diversification via Aryl Sulfonium Salts”

2019 ◽  
Vol 141 (40) ◽  
pp. 16178-16178
Author(s):  
Pascal S. Engl ◽  
Andreas P. Häring ◽  
Florian Berger ◽  
Georg Berger ◽  
Alberto Pérez-Bitrián ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

Photoredox catalysis with aryl sulfonium salts enables site-selective late-stage fluorination

2019 ◽  
Vol 12 (1) ◽  
pp. 56-62 ◽  
Author(s):  
Jiakun Li ◽  
Junting Chen ◽  
Ruocheng Sang ◽  
Won-Seok Ham ◽  
Matthew B. Plutschack ◽  
...  
Keyword(s):  
Late Stage ◽  
Photoredox Catalysis ◽  
Sulfonium Salts ◽  
Site Selective

scholarly journals Site‐Selective Late‐Stage Aromatic [ 18 F]Fluorination via Aryl Sulfonium Salts

2020 ◽  
Vol 59 (5) ◽  
pp. 1956-1960 ◽  
Author(s):  
Peng Xu ◽  
Da Zhao ◽  
Florian Berger ◽  
Aboubakr Hamad ◽  
Jens Rickmeier ◽  
...  
Keyword(s):  
Late Stage ◽  
Sulfonium Salts ◽  
Site Selective

Remote C–H Functionalizations by Ruthenium Catalysis

Synthesis ◽  
2021 ◽  
Author(s):  
Korkit Korvorapun ◽  
Ramesh C. Samanta ◽  
Torben Rogge ◽  
Lutz Ackermann
Keyword(s):  
Steric Hindrance ◽  
Late Stage ◽  
Crop Protection ◽  
Full Control ◽  
Site Selectivity ◽  
Important Approach ◽  
Distinct Character ◽  
Ruthenium Catalysis ◽  
Material Sciences ◽  
Site Selective

Synthetic transformations of otherwise inert C–H bonds have emerged as a powerful tool for molecular modifications during the last decades, with broad applications towards pharmaceuticals, material sciences and crop protection. Consistently, a key challenge in C–H activation chemistry is the full control of site-selectivity. In addition to substrate control through steric hindrance or kinetic acidity of C–H bonds, one important approach for the site-selective C–H transformation of arenes is the use of chelation-assistance through directing groups, therefore leading to proximity-induced ortho-C–H metalation. In contrast, more challenging remote C–H activations at the meta- or para-positions continue to be scarce. Within this review, we demonstrate the distinct character of ruthenium catalysis for remote C–H activations until March 2021, highlighting among others late-stage modifications of bio-relevant molecules. Moreover, we highlight important mechanistic insights by experiments and computation, highlighting the key importance of carboxylate-assisted C–H activation with ruthenium(II) complexes.

Photoinduced Copper-Catalyzed Site-Selective C(sp2)–C(sp) Cross-Coupling via Aryl Sulfonium Salts

2020 ◽  
Vol 22 (17) ◽  
pp. 6842-6846
Author(s):  
Lei Liang ◽  
Hong-Ying Niu ◽  
Ren-Long Li ◽  
Yao-Fei Wang ◽  
Jin-Kai Yan ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Sulfonium Salts ◽  
Site Selective

Site‐Selective C−H Oxygenation via Aryl Sulfonium Salts

2019 ◽  
Vol 131 (45) ◽  
pp. 16307-16312 ◽  
Author(s):  
Ruocheng Sang ◽  
Stamatis E. Korkis ◽  
Wanqi Su ◽  
Fei Ye ◽  
Pascal S. Engl ◽  
...  
Keyword(s):  
Sulfonium Salts ◽  
Site Selective
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