scholarly journals Hydrogen by Deuterium Substitution in an Aldehyde Tunes the Regioselectivity by a Nonheme Manganese(III)–Peroxo Complex

2019 ◽  
Vol 131 (31) ◽  
pp. 10749-10753 ◽  
Author(s):  
Prasenjit Barman ◽  
Fabián G. Cantú Reinhard ◽  
Umesh Kumar Bagha ◽  
Devesh Kumar ◽  
Chivukula V. Sastri ◽  
...  
Keyword(s):  
Peroxo Complex ◽  
Deuterium Substitution

scholarly journals Hydrogen by Deuterium Substitution in an Aldehyde Tunes the Regioselectivity by a Nonheme Manganese(III)–Peroxo Complex

2019 ◽  
Vol 58 (31) ◽  
pp. 10639-10643 ◽  
Author(s):  
Prasenjit Barman ◽  
Fabián G. Cantú Reinhard ◽  
Umesh Kumar Bagha ◽  
Devesh Kumar ◽  
Chivukula V. Sastri ◽  
...  
Keyword(s):  
Peroxo Complex ◽  
Deuterium Substitution

Oxygen-Oxygen Bond Cleavage and Formation in Co(II) Mediated Stoichiometric O2 Reduction via the Potential Intermediacy of a Co(IV) Oxyl Radical

2018 ◽  
Author(s):  
Lucie Nurdin ◽  
Denis M. Spasyuk ◽  
Laura Fairburn ◽  
Warren Piers ◽  
Laurent Maron
Keyword(s):  
Bond Cleavage ◽  
Peroxo Complex ◽  
Oxygen Oxygen ◽  
O2 Reduction ◽  
Oxygen Bond ◽  
Pentadentate Ligand

Diprotonation of a remarkably stable, toluene soluble cobalt peroxo complex supported by a neutral, dianionic pentadentate ligand leads to facile O-O bond cleavage and production of a highly reactive Co(IV) oxyl cation intermediate that dimerizes and releases O<sub>2</sub>. These processes are relevant to both O<sub>2</sub> reduction and O<sub>2</sub> evolution and the mechanism was probed in detail both experimentally and computationally.

Structural and Spectroscopic Characterization of a Monomeric Side-On Manganese(IV) Peroxo Complex

2012 ◽  
Vol 51 (22) ◽  
pp. 5427-5430 ◽  
Author(s):  
Chien-Ming Lee ◽  
Chi-He Chuo ◽  
Ching-Hui Chen ◽  
Cho-Chun Hu ◽  
Ming-Hsi Chiang ◽  
...  
Keyword(s):  
Spectroscopic Characterization ◽  
Peroxo Complex

Investigation of Deuterium Substitution Effects in a Polymer Membrane Using IR Fourier Spectrometry

2018 ◽  
Vol 125 (3) ◽  
pp. 337-342 ◽  
Author(s):  
N. F. Bunkin ◽  
A. A. Balashov ◽  
A. V. Shkirin ◽  
V. S. Gorelik ◽  
A. E. Primenko ◽  
...  
Keyword(s):  
Polymer Membrane ◽  
Substitution Effects ◽  
Deuterium Substitution ◽  
Fourier Spectrometry

Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals

2018 ◽  
Vol 53 (2) ◽  
pp. 211-216 ◽  
Author(s):  
Edward M. Russak ◽  
Edward M. Bednarczyk
Keyword(s):  
Data Extraction ◽  
Metabolic Profiles ◽  
Drug Molecules ◽  
Deuterium Substitution ◽  
Study Selection ◽  
Included Review ◽  
Pharmaceutical Industries ◽  
Process Studies ◽  
Human Use ◽  
To Receive

Objective: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Studies involving the human use of drugs labeled with deuterium suggest that these compounds may offer some advantages when compared with their nondeuterated counterparts. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. Deutetrabenazine (Austedo, Teva Pharmaceutical Industries, Ltd) is the first deuterated drug to receive Food and Drug Administration approval. This deuterated form of the drug tetrabenazine is indicated for the treatment of chorea associated with Huntington’s disease as well as tardive dyskinesia. Ongoing clinical trials suggest that a number of other deuterated compounds are being evaluated for the treatment of human diseases and not merely as research tools. Data Sources: A search of the MEDLINE (1946 to present) database was undertaken using the Ovid interface. The search was conducted using the heading deuterium and then limited to Administration & Dosage, Adverse Effects, Pharmacokinetics, Pharmacology, Poisoning, Therapeutic Use, and Toxicity. Study Selection and Data Extraction: All articles were reviewed and those with human information were included. Review articles were likewise interrogated for additional published human data. Conclusions: Deuterated compounds may, in some cases, offer advantages over nondeuterated forms, often through alterations in clearance. Deuteration may also redirect metabolic pathways in directions that reduce toxicities. The approval of additional deuterated compounds may soon follow. Clinicians will need to be familiar with the dosing, efficacy, potential side effects, and unique metabolic profiles of these new entities.

Molybdenum(VI)-peroxo Complex Catalyzed Oxidation of Alkylbenzenes with Hydrogen Peroxide.

ChemInform ◽  
2003 ◽  
Vol 34 (40) ◽  
Author(s):  
Subhabrata Das ◽  
Tandra Bhowmick ◽  
T. Punniyamurthy ◽  
Deepa Dey ◽  
Jayashree Nath ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Peroxo Complex ◽  
Catalyzed Oxidation

scholarly journals Hydrogen–deuterium substitution in solid ethanol by surface reactions at low temperatures

2016 ◽  
Vol 462 (1) ◽  
pp. 689-695 ◽  
Author(s):  
Yasuhiro Oba ◽  
Kazuya Osaka ◽  
Takeshi Chigai ◽  
Akira Kouchi ◽  
Naoki Watanabe
Keyword(s):  
Low Temperatures ◽  
Surface Reactions ◽  
Deuterium Substitution ◽  
Hydrogen Deuterium

Efficient oxidation of ethyl benzene using in situ generated molybdenum acetylide oxo-peroxo complex as recyclable catalyst

2017 ◽  
Vol 531 ◽  
pp. 45-51 ◽  
Author(s):  
Sonali B. Khomane ◽  
Dhananjay S. Doke ◽  
M.K. Dongare ◽  
S.B. Halligudi ◽  
S.B. Umbarkar
Keyword(s):  
Recyclable Catalyst ◽  
Ethyl Benzene ◽  
Peroxo Complex
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