Enantioselective Total Synthesis of (+)‐Flavisiamine F via Late‐Stage Visible‐Light‐Induced Photochemical Cyclization

2019 ◽  
Vol 131 (16) ◽  
pp. 5497-5500 ◽  
Author(s):  
Xiaogang Tong ◽  
Bingfei Shi ◽  
Kangjiang Liang ◽  
Qian Liu ◽  
Chengfeng Xia
Keyword(s):  
Total Synthesis ◽  
Visible Light ◽  
Late Stage ◽  
Enantioselective Total Synthesis

Enantioselective Total Synthesis of (+)‐Flavisiamine F via Late‐Stage Visible‐Light‐Induced Photochemical Cyclization

2019 ◽  
Vol 58 (16) ◽  
pp. 5443-5446 ◽  
Author(s):  
Xiaogang Tong ◽  
Bingfei Shi ◽  
Kangjiang Liang ◽  
Qian Liu ◽  
Chengfeng Xia
Keyword(s):  
Total Synthesis ◽  
Visible Light ◽  
Late Stage ◽  
Enantioselective Total Synthesis

scholarly journals Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme

2017 ◽  
Vol 139 (30) ◽  
pp. 10196-10199 ◽  
Author(s):  
Steven A. Loskot ◽  
David K. Romney ◽  
Frances H. Arnold ◽  
Brian M. Stoltz
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Enantioselective Total Synthesis ◽  
P450 Enzyme

Synthesis and absolute configuration assignment of albucidin: a late-stage reductive deiodination by visible light photocatalysis

2016 ◽  
Vol 14 (13) ◽  
pp. 3482-3485 ◽  
Author(s):  
Hu Zhang ◽  
Peng-Fei Liu ◽  
Qiong Chen ◽  
Qiong-You Wu ◽  
Anne Seville ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Visible Light ◽  
Absolute Configuration ◽  
Late Stage ◽  
Visible Light Photocatalysis ◽  
Configuration Assignment ◽  
Bioactive Molecule ◽  
The Way

The total synthesis and absolute configuration assignment of albucidin might pave the way for synthetic and medicinal chemists for further research on this type of bioactive molecule.

Enantioselective total synthesis of (+)-ieodomycin A, (+)-ieodomycin B, and their three stereoisomers

2020 ◽  
Author(s):  
Du-Bong Choi ◽  
Hansol Choi ◽  
Jihoon Lee ◽  
Yeon-Ju Lee ◽  
Hyi-Seung Lee ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Side Chain ◽  
Enantioselective Total Synthesis

Enantioselective routes for the total synthesis of ieodomycins A & B, and three stereochemical analogues of ieodomycin B via a late-stage elaboration of the side chain.

Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Aneta Turlik ◽  
Yifeng Chen ◽  
Anthony Scruse
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Late Stage ◽  
Membered Ring ◽  
Entry Point ◽  
Ketone Reduction ◽  
Coupling Approach

<div> <p>The total synthesis of principinol D, a rearranged kaurane diterpenoid, is reported. This grayanane natural product is constructed via a convergent fragment coupling approach, wherein the central 7-membered ring is synthesized at a late stage. The bicyclo[3.2.1]octane fragment is accessed by a Ni-catalyzed α-vinylation reaction. Strategic reductions include a diastereoselective SmI<sub>2</sub>-mediated ketone reduction with PhSH and a new protocol for selective ester reduction in the presence of ketones. The convergent strategy reported herein may be an entry point to the larger class of kaurane diterpenoids.</p> </div>

The Total Synthesis of Rhabdastrellic Acid A

2018 ◽  
Author(s):  
Yaroslav Boyko ◽  
Christopher Huck ◽  
David Sarlah
Keyword(s):  
Total Synthesis ◽  
Late Stage ◽  
Cross Coupling ◽  
Side Chains ◽  
General Strategy ◽  
Modular Approach ◽  
Linear Sequence ◽  
Generating Sequence ◽  
First Time

<div>The first total synthesis of rhabdastrellic acid A, a highly cytotoxic isomalabaricane triterpenoid, has been accomplished in a linear sequence of 14 steps from commercial geranylacetone. The prominently strained <i>trans-syn-trans</i>-perhydrobenz[<i>e</i>]indene core characteristic of the isomalabaricanes is efficiently accessed in a selective manner for the first time through a rapid, complexity-generating sequence incorporating a reductive radical polyene cyclization, an unprecedented oxidative Rautenstrauch cycloisomerization, and umpolung 𝛼-substitution of a <i>p</i>-toluenesulfonylhydrazone with in situ reductive transposition. A late-stage cross-coupling in concert with a modular approach to polyunsaturated side chains renders this a general strategy for the synthesis of numerous family members of these synthetically challenging and hitherto inaccessible marine triterpenoids.</div>

scholarly journals Enantioselective Total Synthesis of (+)‐Garsubellin A

2021 ◽  
Author(s):  
Dongseok Jang ◽  
Minchul Choi ◽  
Jinglong Chen ◽  
Chulbom Lee
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Enantioselective Total Synthesis of ( – )‐Spiroxins A, C and D

2021 ◽  
Author(s):  
Xin Shu ◽  
Chong-Chong Chen ◽  
Tao Yu ◽  
Jiayi Yang ◽  
Xiangdong Hu
Keyword(s):  
Total Synthesis ◽  
Enantioselective Total Synthesis

Unified enantioselective total synthesis of 3,6-dioxygenated diketopiperazine natural products, diatretol and lepistamides A, B and C

2021 ◽  
Vol 67 ◽  
pp. 152895
Author(s):  
Shu Takahashi ◽  
Aoi Kimishima ◽  
Tomoyasu Hirose ◽  
Takeshi Yamada ◽  
Akihiro Sugawara ◽  
...  
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Enantioselective Total Synthesis
Sign in / Sign up

Export Citation Format

Share Document