Total Synthesis and Anticancer Activity of (+)‐Hypercalin C and Congeners

2019 ◽  
Vol 131 (9) ◽  
pp. 2760-2764 ◽  
Author(s):  
Yongfeng Tao ◽  
Keighley Reisenauer ◽  
Joseph H. Taube ◽  
Daniel Romo
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

scholarly journals Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation

2019 ◽  
Vol 141 (12) ◽  
pp. 4849-4860 ◽  
Author(s):  
Hem Raj Khatri ◽  
Bijay Bhattarai ◽  
Will Kaplan ◽  
Zhongzheng Li ◽  
Marcus John Curtis Long ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity ◽  
Activity Evaluation

ChemInform Abstract: First Total Synthesis of Prasinic Acid and Its Anticancer Activity.

ChemInform ◽  
2013 ◽  
Vol 44 (12) ◽  
pp. no-no
Author(s):  
Narayan Chakor ◽  
Ganesh Patil ◽  
Diana Writer ◽  
Giridharan Periyasamy ◽  
Rajiv Sharma ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

scholarly journals Synthetic Approaches to Tetracyclic Pyrrole Imidazole Marine Alkaloids

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Takuya Imaoka ◽  
Makoto Iwata ◽  
Takafumi Akimoto ◽  
Kazuo Nagasawa
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Biological Activities ◽  
Structural Complexity ◽  
Marine Alkaloids ◽  
Ring Systems ◽  
Agonistic Activity ◽  
Synthetic Approaches

Oroidin derived pyrrole imidazole marine alkaloids (PIAs) are attractive targets for synthetic organic chemists because of their structural complexity and diversity as well as their interesting biological activities. A number of efforts have been carried out to develop strategies for the synthesis of these natural products. Members of PIAs ( eg., 2-7) which contain tetracyclic ring systems possessing characteristic cyclic guanidine or urea moieties show significant biological activities including anticancer activity and agonistic activity against the adrenoceptor. In this review investigations of the total synthesis of the representative tetracyclic PIAs dibromophakellin (2) and dibromophakellstatin (3) are described.

scholarly journals Total Synthesis and Anticancer Activity of (+)‐Hypercalin C and Congeners

2019 ◽  
Vol 58 (9) ◽  
pp. 2734-2738 ◽  
Author(s):  
Yongfeng Tao ◽  
Keighley Reisenauer ◽  
Joseph H. Taube ◽  
Daniel Romo
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

Total synthesis and anticancer activity of highly potent novel glycolipid derivatives

2009 ◽  
Vol 44 (8) ◽  
pp. 3120-3129 ◽  
Author(s):  
Mankil Jung ◽  
Yongnam Lee ◽  
Hyung-In Moon ◽  
Youngae Jung ◽  
Haein Jung ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

Science ◽  
2013 ◽  
Vol 341 (6148) ◽  
pp. 878-882 ◽  
Author(s):  
Lars Jørgensen ◽  
Steven J. McKerrall ◽  
Christian A. Kuttruff ◽  
Felix Ungeheuer ◽  
Jakob Felding ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity ◽  
Actinic Keratosis ◽  
Skin Condition ◽  
Chemical Production ◽  
Two Phase ◽  
Chemical Complexity ◽  
Euphorbia Peplus ◽  
Stereocontrolled Synthesis ◽  
Phase Design

Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity, including the recently Food and Drug Administration–approved Picato, a first-in-class drug for the treatment of the precancerous skin condition actinic keratosis. Currently, that compound is sourced inefficiently from Euphorbia peplus. Here, we detail an efficient, highly stereocontrolled synthesis of (+)-ingenol proceeding in only 14 steps from inexpensive (+)-3-carene and using a two-phase design. This synthesis will allow for the creation of fully synthetic analogs of bioactive ingenanes to address pharmacological limitations and provides a strategic blueprint for chemical production. These results validate two-phase terpene total synthesis as not only an academic curiosity but also a viable alternative to isolation or bioengineering for the efficient preparation of polyoxygenated terpenoids at the limits of chemical complexity.

scholarly journals Total synthesis and anticancer activity of the natural oleanolic acid bidesmoside saponin, albidoside A, isolated from the roots of Acacia albida

2019 ◽  
Vol 44 (1-2) ◽  
pp. 42-49
Author(s):  
Tiantian Guo ◽  
Yiming Song ◽  
Yinghui Lu ◽  
Guolin Li ◽  
Tian Liu ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Hela Cell ◽  
Anticancer Activity ◽  
Cell Line ◽  
Oleanolic Acid ◽  
Triterpenoid Saponin ◽  
Hela Cell Line ◽  
Hela Cell Lines ◽  
Acacia Albida ◽  
Mcf 7

The first synthesis of a natural triterpenoid saponin bearing N-acetylglucosamine, albidoside A, which is isolated from the roots of Acacia albida, is concisely achieved in a convergent strategy. Preliminary pharmacological research shows anticancer activity against HL-60, MCF-7, MDA-MB-231, Hep-2, and Hela cell lines. In particular, it exhibited good selectivity, which is five times more cytotoxic toward Hep-2 cells (IC50 = 8.91 μM) than the Hela cell line.

First total synthesis of prasinic acid and its anticancer activity

2012 ◽  
Vol 22 (21) ◽  
pp. 6608-6610 ◽  
Author(s):  
Narayan Chakor ◽  
Ganesh Patil ◽  
Diana Writer ◽  
Giridharan Periyasamy ◽  
Rajiv Sharma ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity

Concise total synthesis of water soluble metatacarboline A, C, D, E and F and its anticancer activity

2016 ◽  
Vol 113 ◽  
pp. 167-178 ◽  
Author(s):  
Badher Naveen ◽  
Anwita Mudiraj ◽  
Geeviman Khamushavalli ◽  
Phanithi Prakash Babu ◽  
Rajagopal Nagarajan
Keyword(s):  
Total Synthesis ◽  
Anticancer Activity ◽  
Water Soluble

scholarly journals Paclitaxel as an anticancer agent: isolation, activity, synthesis and stability

Open Medicine ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. 527-536 ◽  
Author(s):  
Vesna Nikolic ◽  
Ivan Savic ◽  
Ivana Savic ◽  
Ljubisa Nikolic ◽  
Mihajlo Stankovic ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Total Synthesis ◽  
Anticancer Activity ◽  
Plant Material ◽  
Anticancer Agent ◽  
Aqueous Media ◽  
The Pacific ◽  
Other Substances ◽  
Synthesis Procedure ◽  
Isolated Compound

AbstractPaclitaxel is isolated from the Pacific yew. It can be obtained from the European yew, but only after chemical modification of the isolated compound by a semi-synthesis procedure. The procedure for total synthesis of paclitaxel is very complicated, involving multiple steps, and the yields of paclitaxel are meagre. This substance is also a metabolite of certain kinds of fungus. The microbiological pathway for producing paclitaxel compared with isolation from plant material involves shorter procuction times but a small yield. Cyclodextrins are usually used for improving the solubility of paclitaxel in aqueous media, with polymeric and other substances added. Paclitaxel has anticancer activity and use for preparing the formulations intravenously administrated to patients with tumors. The paclitaxel concentration in these formulations is determined using validated HPLC methods.

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