scholarly journals Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy

2018 ◽  
Vol 130 (10) ◽  
pp. 2717-2721 ◽  
Author(s):  
Lalit Deshmukh ◽  
Vitali Tugarinov ◽  
Daniel H. Appella ◽  
G. Marius Clore
Keyword(s):  
Excited State ◽  
Nmr Spectroscopy ◽  
Hiv 1

scholarly journals Targeting a Dark Excited State of HIV-1 Nucleocapsid by Antiretroviral Thioesters Revealed by NMR Spectroscopy

2018 ◽  
Vol 57 (10) ◽  
pp. 2687-2691 ◽  
Author(s):  
Lalit Deshmukh ◽  
Vitali Tugarinov ◽  
Daniel H. Appella ◽  
G. Marius Clore
Keyword(s):  
Excited State ◽  
Nmr Spectroscopy ◽  
Hiv 1

scholarly journals Dynamic Nuclear Polarization Enhanced MAS NMR Spectroscopy for Structural Analysis of HIV-1 Protein Assemblies

2016 ◽  
Vol 120 (2) ◽  
pp. 329-339 ◽  
Author(s):  
Rupal Gupta ◽  
Manman Lu ◽  
Guangjin Hou ◽  
Marc A. Caporini ◽  
Melanie Rosay ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Structural Analysis ◽  
Dynamic Nuclear Polarization ◽  
Nuclear Polarization ◽  
Mas Nmr ◽  
Protein Assemblies ◽  
Hiv 1

scholarly journals Competitive displacement of full-length HIV-1 Nef from the Hck SH3 domain by a high-affinity artificial peptide

2007 ◽  
Vol 388 (6) ◽  
pp. 611-615 ◽  
Author(s):  
Thomas Stangler ◽  
Tuyen Tran ◽  
Silke Hoffmann ◽  
Holger Schmidt ◽  
Esther Jonas ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Phage Display ◽  
Dissociation Constant ◽  
Sh3 Domain ◽  
Competitive Displacement ◽  
Ligand Interaction ◽  
High Affinity ◽  
Hematopoietic Cell Kinase ◽  
Proline Rich Peptide ◽  
Hiv 1

AbstractWe studied the interaction of the artificial 12-aa proline-rich peptide PD1 with the SH3 domain of the hematopoietic cell kinase Hck and the peptide's potency in competitively displacing HIV-1 Nef from the Hck SH3 domain. PD1 was obtained from a phage display screen and exhibits exceptional affinity for the Hck SH3 domain (Kd=0.23 μM). Competition experiments using NMR spectroscopy demonstrate that the peptide even displaces Nef from Hck SH3 and allow for estimation of the Nef-Hck SH3 dissociation constant (Kd=0.44 μM), the strongest SH3 ligand interaction known so far. Consequences of this study for novel antiviral concepts are discussed.

scholarly journals Conformation of Inhibitor-Free HIV-1 Protease Derived from NMR Spectroscopy in a Weakly Oriented Solution

ChemBioChem ◽  
2014 ◽  
Vol 16 (2) ◽  
pp. 214-218 ◽  
Author(s):  
Julien Roche ◽  
John M. Louis ◽  
Ad Bax
Keyword(s):  
Nmr Spectroscopy ◽  
Hiv 1

scholarly journals Fast Magic-Angle Spinning 19 F NMR Spectroscopy of HIV-1 Capsid Protein Assemblies

2018 ◽  
Vol 57 (50) ◽  
pp. 16375-16379 ◽  
Author(s):  
Mingzhang Wang ◽  
Manman Lu ◽  
Matthew P. Fritz ◽  
Caitlin M. Quinn ◽  
In-Ja L. Byeon ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Capsid Protein ◽  
Magic Angle Spinning ◽  
Magic Angle ◽  
Protein Assemblies ◽  
Angle Spinning ◽  
Fast Magic Angle Spinning ◽  
Hiv 1 ◽  
19 F Nmr

scholarly journals NMR spectroscopy of HIV-1 gp120 outer domain

Retrovirology ◽  
2012 ◽  
Vol 9 (S2) ◽  
Author(s):  
M Sastry ◽  
L Xu ◽  
S Bhattacharya ◽  
GJ Nabel ◽  
CA Bewley ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Outer Domain ◽  
Hiv 1

scholarly journals Mapping the interaction between the cytoplasmic domains of HIV-1 viral protein U and human CD4 with NMR spectroscopy

FEBS Journal ◽  
2012 ◽  
Vol 279 (19) ◽  
pp. 3705-3714 ◽  
Author(s):  
Sameer K. Singh ◽  
Luis Möckel ◽  
Pallavi Thiagarajan-Rosenkranz ◽  
Marc Wittlich ◽  
Dieter Willbold ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Viral Protein ◽  
Cytoplasmic Domains ◽  
Viral Protein U ◽  
Hiv 1

Mapping the binding site of full length HIV-1 Nef on human Lck SH3 by NMR spectroscopy

2005 ◽  
Vol 12 (3) ◽  
pp. 451-456 ◽  
Author(s):  
Lars Briese ◽  
Andrea Preusser ◽  
Dieter Willbold
Keyword(s):  
Nmr Spectroscopy ◽  
Binding Site ◽  
Full Length ◽  
Hiv 1
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