Magnetic Mesoporous Silica Nanoparticles Cloaked by Red Blood Cell Membranes: Applications in Cancer Therapy

2018 ◽  
Vol 130 (21) ◽  
pp. 6157-6161 ◽  
Author(s):  
Mingjun Xuan ◽  
Jingxin Shao ◽  
Jie Zhao ◽  
Qi Li ◽  
Luru Dai ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Blood Cell ◽  
Silica Nanoparticles ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
Red Blood Cell Membranes ◽  
Magnetic Mesoporous Silica

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

ACS Nano ◽  
2011 ◽  
Vol 5 (2) ◽  
pp. 1366-1375 ◽  
Author(s):  
Yannan Zhao ◽  
Xiaoxing Sun ◽  
Guannan Zhang ◽  
Brian G. Trewyn ◽  
Igor I. Slowing ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Blood Cell ◽  
Silica Nanoparticles ◽  
Red Blood Cell ◽  
Cell Membranes ◽  
Mesoporous Silica Nanoparticles ◽  
Surface Effects ◽  
Red Blood Cell Membranes

Fucoidan-coated core–shell magnetic mesoporous silica nanoparticles for chemotherapy and magnetic hyperthermia-based thermal therapy applications

2017 ◽  
Vol 41 (24) ◽  
pp. 15334-15346 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Bharathiraja Subramanian ◽  
Manivasagan Panchanathan ◽  
Sudip Mondal ◽  
Hyehyun Kim ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Thermal Therapy ◽  
Core Shell ◽  
Magnetic Mesoporous Silica

Fucoidan-coated FeNP@SiOH@Fuc NPs have been proposed for chemotherapy and thermal therapy applications in emerging cancer therapy.

A smart magnetic nanosystem with controllable drug release and hyperthermia for potential cancer therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (121) ◽  
pp. 99875-99883 ◽  
Author(s):  
Yi Xu ◽  
Yufang Zhu ◽  
Stefan Kaskel
Keyword(s):  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Modified Dna ◽  
Therapeutic Platform ◽  
Magnetic Mesoporous Silica ◽  
Potential Cancer

A smart therapeutic platform with potential controllable drug release and magnetic hyperthermia was constructed through the conjugation of carboxyl-modified DNA onto aminated magnetic mesoporous silica nanoparticles.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

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