Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction

2018 ◽  
Vol 130 (19) ◽  
pp. 5386-5389 ◽  
Author(s):  
Xavier Garrabou ◽  
Duncan Stuart Macdonald ◽  
Basile I. M. Wicky ◽  
Donald Hilvert
Keyword(s):  
Michael Reaction ◽  
Artificial Enzymes ◽  
The Michael Reaction

Stereodivergent Evolution of Artificial Enzymes for the Michael Reaction

2018 ◽  
Vol 57 (19) ◽  
pp. 5288-5291 ◽  
Author(s):  
Xavier Garrabou ◽  
Duncan Stuart Macdonald ◽  
Basile I. M. Wicky ◽  
Donald Hilvert
Keyword(s):  
Michael Reaction ◽  
Artificial Enzymes ◽  
The Michael Reaction

Sterically hindered 1,3-diketones in the Michael reaction

1996 ◽  
Vol 45 (1) ◽  
pp. 137-139
Author(s):  
I. E. Sokolov ◽  
A. S. Zanina ◽  
S. I. Shergina ◽  
M. S. Shvartsberg
Keyword(s):  
Michael Reaction ◽  
Sterically Hindered ◽  
The Michael Reaction

The Michael Reaction

2002 ◽  
Vol 79 (2) ◽  
pp. 264 ◽  
Author(s):  
Thomas Poon ◽  
Bradford P. Mundy ◽  
Thomas W. Shattuck
Keyword(s):  
Michael Reaction ◽  
The Michael Reaction

scholarly journals Preparation of Polyamines by the Michael Reaction

1968 ◽  
Vol 41 (10) ◽  
pp. 2519-2521 ◽  
Author(s):  
Kentaro Yoda ◽  
Takao Toda
Keyword(s):  
Michael Reaction ◽  
The Michael Reaction

scholarly journals One-pot synthesis of (1RS,21SR)-diethyl 2-[23-amino-22-ethoxycarbonyl-8,11,14-trioxa-25-azatetracyclo[19.3.1.02,7.015,20]pentacosa-2,4,6,15(20),16,18,22-heptaen-25-yl]but-2-endioate

2018 ◽  
Vol 74 (9) ◽  
pp. 1281-1284
Author(s):  
Thi Thanh Van Tran ◽  
Tuan Anh Le ◽  
Hong Hieu Truong ◽  
Thi Nhung Dao ◽  
Anatoly T. Soldatenkov ◽  
...  
Keyword(s):  
Hydrogen Bonds ◽  
Molecular Conformation ◽  
Michael Reaction ◽  
Biological Activities ◽  
Boat Conformation ◽  
One Pot ◽  
Computer Prediction ◽  
Compound C ◽  
Intramolecular Hydrogen ◽  
The Michael Reaction

The title compound, C30H34N2O9 (4), is a product of the Michael reaction of azacrown ether with dimethyl acetylenedicarboxylate modified by an addition of NH3 (aq.) at 298 K. The aza-14-crown-4-ether ring adopts a bowl conformation. The dihedral angle between the planes of the benzene rings fused to the aza-14-crown-4-ether moiety is 8.65 (5)°. The tetrahydropyridine ring has a boat conformation. The molecular conformation is supported by one N—H...O and two C—H...O intramolecular hydrogen bonds. Both heterocyclic and amino N atoms have essentially planar configurations (sums of the bond angles are 359.35 and 358.00°). Compound 4 crystallizes as a racemate consisting of enantiomeric pairs of the 1R,21S diastereomer. In the crystal, molecules of 4 are connected by N—H...O hydrogen bonds, forming chains along [100]. According to the PASS program (computer prediction of biological activities), compound 4 may exhibit antiallergic (72% probability) and antiasthmatic (67%) activity, as well as be a membrane permeability inhibitor (65%).

ChemInform Abstract: Ethyl α-Cyanoacrylate in the Michael Reaction.

ChemInform ◽  
2010 ◽  
Vol 25 (26) ◽  
pp. no-no
Author(s):  
I. I. KANDROR ◽  
M. A. GALKINA ◽  
I. O. BRAGINA ◽  
B. D. LAVRUKHIN ◽  
YU. N. BELOKON' ◽  
...  
Keyword(s):  
Michael Reaction ◽  
The Michael Reaction
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