Nickel-Catalyzed Conjugate Addition of Silyl Ketene Imines to In Situ Generated Indol-2-ones: Highly Enantioselective Construction of Vicinal All-Carbon Quaternary Stereocenters

2017 ◽  
Vol 129 (42) ◽  
pp. 13287-13291 ◽  
Author(s):  
Jianfeng Zheng ◽  
Lili Lin ◽  
Li Dai ◽  
Qiong Tang ◽  
Xiaohua Liu ◽  
...  
Keyword(s):  
Conjugate Addition ◽  
Quaternary Stereocenters

Copper-catalyzed conjugate addition of in situ formed alkyl boranes to α,β-unsaturated ketones

2018 ◽  
Vol 150 (2) ◽  
pp. 295-302
Author(s):  
Bernard Mravec ◽  
Kristína Plevová ◽  
Radovan Šebesta
Keyword(s):  
Conjugate Addition ◽  
Unsaturated Ketones

Bifunctional tertiary amine-squaramide catalyzed asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides with oxindoles

2016 ◽  
Vol 52 (22) ◽  
pp. 4183-4186 ◽  
Author(s):  
Yu-Hua Deng ◽  
Xiang-Zhi Zhang ◽  
Ke-Yin Yu ◽  
Xu Yan ◽  
Ji-Yuan Du ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Conjugate Addition ◽  
Quinone Methides ◽  
Asymmetric Catalytic ◽  
Quaternary Stereocenters

A novel organocatalytic enantioselective 1,6-addition of p-QMs has been developed to access diarylmethine-functionalized oxindoles bearing vicinal tertiary and quaternary stereocenters.

Asymmetric construction of quaternary stereocenters by direct conjugate addition of oxindoles to enone

2010 ◽  
Vol 21 (20) ◽  
pp. 2493-2497 ◽  
Author(s):  
Wangsheng Sun ◽  
Liang Hong ◽  
Chunxia Liu ◽  
Rui Wang
Keyword(s):  
Conjugate Addition ◽  
Quaternary Stereocenters

Construction of trifluoromethylated quaternary stereocenters via p-quinone methides

2020 ◽  
Vol 56 (20) ◽  
pp. 3031-3034 ◽  
Author(s):  
Kyu Terashima ◽  
Tomoko Kawasaki-Takasuka ◽  
Tomohiro Agou ◽  
Toshio Kubota ◽  
Takashi Yamazaki
Keyword(s):  
Synthetic Method ◽  
Quinone Methides ◽  
Quaternary Centers ◽  
Quaternary Stereocenters

Development of a new synthetic method for the construction of quaternary centers with a CF3 group was realized by way of 1,6-addition of various nucleophiles to highly reactive δ-trifluoromethylated p-quinone methides generated in situ.

scholarly journals One-pot odourless synthesis of thioesters via in situ generation of thiobenzoic acids using benzoic anhydrides and thiourea

2015 ◽  
Vol 11 ◽  
pp. 1265-1273 ◽  
Author(s):  
Mohammad Abbasi ◽  
Reza Khalifeh
Keyword(s):  
Conjugate Addition ◽  
Alkyl Halides ◽  
Displacement Reaction ◽  
One Pot ◽  
One Pot Synthesis ◽  
Organic Halides ◽  
Nucleophilic Displacement ◽  
In Situ Generation

An efficient and odourless procedure for a one-pot synthesis of thioesters by the reaction of benzoic anhydrides, thiourea and various organic halides (primary, allylic, and benzylic) or structurally diverse, electron-deficient alkenes (ketones, esters, and nitriles) in the presence of Et3N has been developed. In this method, thiobenzoic acids were in situ generated from the reaction of thiourea with benzoic anhydrides, which were subjected to conjugate addition with electron-deficient alkenes or a nucleophilic displacement reaction with alkyl halides.

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