Metal-free Synthesis of Aryl Amines: Beyond Nucleophilic Aromatic Substitution

2016 ◽  
Vol 128 (51) ◽  
pp. 16044-16047 ◽  
Author(s):  
Alexander H. Sandtorv ◽  
David R. Stuart
Keyword(s):  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Metal Free ◽  
Aryl Amines

Deuterated Aryl Alkyl Ethers Synthesis via Nucleophilic Etherification of Aryl Alkyl Ethers and Thioethers with Deuterated Alcohols

Synlett ◽  
2019 ◽  
Vol 30 (15) ◽  
pp. 1805-1809
Author(s):  
Shuai Li ◽  
Xia Wang ◽  
Xin-Ge Yang ◽  
Gui-Quan Yu ◽  
Xue-Qiang Wang
Keyword(s):  
Transition Metal ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Mechanistic Studies ◽  
Reaction Conditions ◽  
Metal Free ◽  
Wide Range ◽  
Alkyl Ethers

A transition-metal-free etherification protocol that is capable of synthesizing deuterated ethers is described. A wide range of aryl alkyl ethers and thioethers were suitable for this transformation owing to the mild reaction conditions. Besides, a series of sterically bulky deuterated alcohols were successfully incorporated into cyano-substituted arenes. The results of mechanistic studies suggested this reaction might take place via nucleophilic aromatic substitution pathway.

Transition metal-free construction of trinuclear N-fused hybrid scaffolds by double nucleophilic aromatic substitution under microwave irradiation

2019 ◽  
Vol 21 (24) ◽  
pp. 6590-6593 ◽  
Author(s):  
Pham Duy Quang Dao ◽  
Ho-Jin Lim ◽  
Chan Sik Cho
Keyword(s):  
Transition Metal ◽  
Microwave Irradiation ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Metal Free ◽  
Green Construction ◽  
Free Construction ◽  
Hybrid Scaffolds

A green construction of trinuclear N-fused hybrid scaffolds by transition metal-free double C(sp2)–N coupling of 2-(2-bromoaryl)- and 2-(2-bromovinyl)benzimidazoles with 2-aminoazoles under microwave irradiation has been developed.

scholarly journals Transition-metal-free Nucleophilic 211At-astatination of Spirocyclic Aryliodonium Ylides

2021 ◽  
Author(s):  
Keitaro Matsuoka ◽  
Honoka Obata ◽  
Nagatsu Kotaro ◽  
Masahiro Kojima ◽  
Tatsuhiko Yoshino ◽  
...  
Keyword(s):  
Transition Metal ◽  
Substitution Reaction ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Metal Free ◽  
Radiolabeled Compounds

The transition-metal-free 211At-astatination of spirocyclic aryliodonium ylides via a nucleophilic aromatic substitution reaction is described. This method enables the preparation of 211At-radiolabeled compounds derived from multi-functionalized molecules and heteroarenes in...

Intramolecular Nucleophilic Aromatic Substitution Reaction of 2-Carboxamido-3-arylquinazolin-4-ones and its Application to the Synthesis of Secondary Aryl Amines

Synlett ◽  
2004 ◽  
Vol 2004 (14) ◽  
pp. 2497-2500 ◽  
Author(s):  
Hideaki Natsugari ◽  
Haruhiko Fuwa ◽  
Toshitake Kobayashi ◽  
Takashi Tokitoh ◽  
Yukiko Torii
Keyword(s):  
Substitution Reaction ◽  
Nucleophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Aryl Amines
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