Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α-Ketoacid-Hydroxylamine (KAHA) Ligation

2015 ◽  
Vol 127 (44) ◽  
pp. 13188-13193 ◽  
Author(s):  
Chunmao He ◽  
Sameer S. Kulkarni ◽  
Frédéric Thuaud ◽  
Jeffrey W. Bode
Keyword(s):  
Chemical Synthesis ◽  
Heme Protein ◽  
Nitrophorin 4

Chemical Synthesis of the 20 kDa Heme Protein Nitrophorin 4 by α-Ketoacid-Hydroxylamine (KAHA) Ligation

2015 ◽  
Vol 54 (44) ◽  
pp. 12996-13001 ◽  
Author(s):  
Chunmao He ◽  
Sameer S. Kulkarni ◽  
Frédéric Thuaud ◽  
Jeffrey W. Bode
Keyword(s):  
Chemical Synthesis ◽  
Heme Protein ◽  
Nitrophorin 4

scholarly journals The crystal structure of nitrophorin 4 at 1.5 å resolution: transport of nitric oxide by a lipocalin-based heme protein

Structure ◽  
1998 ◽  
Vol 6 (10) ◽  
pp. 1315-1327 ◽  
Author(s):  
John F Andersen ◽  
Andrzej Weichsel ◽  
Celia A Balfour ◽  
Donald E Champagne ◽  
William R Montfort
Keyword(s):  
Crystal Structure ◽  
Nitric Oxide ◽  
Heme Protein ◽  
Nitrophorin 4

Chemical synthesis of proteinoids: Part 1

1964 ◽  
Author(s):  
Sidney W. Fox ◽  
Kaoru Harada ◽  
Gottfried Krampitz ◽  
Tadao Hayakawa ◽  
Charles Ray Windsor
Keyword(s):  
Chemical Synthesis

Chemical Synthesis of Peptides

2012 ◽  
Vol 2 (2) ◽  
pp. 147-149
Author(s):  
Tanaji Dnyanadev Padalkar ◽  
Keyword(s):  
Chemical Synthesis

Microbe Engineering of Guaia-6,10(14)-diene as a Building Block for the Semisynthetic Production of Plant-Derived (−)-Englerin A

2019 ◽  
Author(s):  
Thomas Siemon ◽  
Zhangqian Wang ◽  
Guangkai Bian ◽  
Tobias Seitz ◽  
Ziling Ye ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Saccharomyces Cerevisiae ◽  
Synthetic Biology ◽  
Chemical Synthesis ◽  
Building Block ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Economical Method ◽  
Englerin A ◽  
Transient Receptor

Herein, we report the semisynthetic production of the potent transient receptor potential canonical (TRPC) channel agonist (−)-englerin A (EA), using guaia-6,10(14)-diene as the starting material. Guaia-6,10(14)-diene was systematically engineered in Escherichia coli and Saccharomyces cerevisiae using the CRISPR/Cas9 system and produced with high titers. This provided us the opportunity to execute a concise chemical synthesis of EA and the two related guaianes (−)-oxyphyllol and (+)-orientalol E. The potentially scalable approach combines the advantages of synthetic biology and chemical synthesis and provides an efficient and economical method for producing EA as well as its analogs.

Sign in / Sign up

Export Citation Format

Share Document