Uncovering the Stoichiometry ofPyrococcus furiosusRNase P, a Multi-Subunit Catalytic Ribonucleoprotein Complex, by Surface-Induced Dissociation and Ion Mobility Mass Spectrometry

2014 ◽  
Vol 126 (43) ◽  
pp. 11667-11671 ◽  
Author(s):  
Xin Ma ◽  
Lien B. Lai ◽  
Stella M. Lai ◽  
Akiko Tanimoto ◽  
Mark P. Foster ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry ◽  
Ribonucleoprotein Complex ◽  
Surface Induced Dissociation

Possible isomers in ligand protected Ag11cluster ions identified by ion mobility mass spectrometry and fragmented by surface induced dissociation

2016 ◽  
Vol 52 (19) ◽  
pp. 3805-3808 ◽  
Author(s):  
Ananya Baksi ◽  
Sophie R. Harvey ◽  
Ganapati Natarajan ◽  
Vicki H. Wysocki ◽  
Thalappil Pradeep
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Collision Induced Dissociation ◽  
Silver Clusters ◽  
Ion Mobility Mass Spectrometry ◽  
Surface Induced Dissociation

Isomeric glutathione protected silver clusters have been detected using ion mobility mass spectrometry. This cluster has been fragmented by conventional collision induced dissociation and newly introduced surface induced dissociation.

scholarly journals Surface induced dissociation as a tool to study membrane protein complexes

2017 ◽  
Vol 53 (21) ◽  
pp. 3106-3109 ◽  
Author(s):  
Sophie R. Harvey ◽  
Yang Liu ◽  
Wen Liu ◽  
Vicki H. Wysocki ◽  
Arthur Laganowsky
Keyword(s):  
Mass Spectrometry ◽  
Membrane Protein ◽  
Ion Mobility ◽  
Protein Complexes ◽  
Integral Membrane Protein ◽  
Ion Mobility Mass Spectrometry ◽  
Surface Induced Dissociation ◽  
Membrane Protein Complexes

Native ion mobility mass spectrometry (MS) and surface induced dissociation (SID) are applied to study the integral membrane protein complexes AmtB and AqpZ.

Rapid Diagnosis of Parkinson’s Disease from Sebum using Paper Spray Ionisation Ion Mobility Mass Spectrometry

2020 ◽  
Author(s):  
Depanjan Sarkar ◽  
Drupad Trivedi ◽  
Eleanor Sinclair ◽  
Sze Hway Lim ◽  
Caitlin Walton-Doyle ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ion Mobility ◽  
Neurodegenerative Disorder ◽  
Treatment Options ◽  
Ion Mobility Mass Spectrometry ◽  
Paper Spray ◽  
Molecular Features ◽  
Validation Set

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which identification of robust biomarkers to complement clinical PD diagnosis would accelerate treatment options and help to stratify disease progression. Here we demonstrate the use of paper spray ionisation coupled with ion mobility mass spectrometry (PSI IM-MS) to determine diagnostic molecular features of PD in sebum. PSI IM-MS was performed directly from skin swabs, collected from 34 people with PD and 30 matched control subjects as a training set and a further 91 samples from 5 different collection sites as a validation set. PSI IM-MS elucidates ~ 4200 features from each individual and we report two classes of lipids (namely phosphatidylcholine and cardiolipin) that differ significantly in the sebum of people with PD. Putative metabolite annotations are obtained using tandem mass spectrometry experiments combined with accurate mass measurements. Sample preparation and PSI IM-MS analysis and diagnosis can be performed ~5 minutes per sample offering a new route to for rapid and inexpensive confirmatory diagnosis of this disease.

P‐97: Separation of Isomeric OLED Materials Using Ion Mobility‐Mass Spectrometry (IM‐MS)

2021 ◽  
Vol 52 (1) ◽  
pp. 1444-1447
Author(s):  
Hirotaka Shioji ◽  
Azusa Uematsu ◽  
Motoshi Onoda ◽  
Keiko Matsuda ◽  
Keisuke Sawada ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry
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