Coupling of Sterically Hindered Trisubstituted Olefins and Benzocyclobutenones by CC Activation: Total Synthesis and Structural Revision of Cycloinumakiol

2014 ◽  
Vol 126 (40) ◽  
pp. 10909-10912 ◽  
Author(s):  
Tao Xu ◽  
Guangbin Dong
Keyword(s):  
Total Synthesis ◽  
Structural Revision ◽  
Trisubstituted Olefins ◽  
Sterically Hindered

Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion

2019 ◽  
Author(s):  
Timothy Newhouse ◽  
Alexander Schuppe ◽  
Yizhou Zhao ◽  
Yannan Liu
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Knoevenagel Condensation ◽  
Cost Effective ◽  
Effective Procedure ◽  
Direct Transformation ◽  
Structural Revision ◽  
Alpha Beta ◽  
Ptp 1B

We report the first total synthesis of (+)-granatumine A, a limonoid alkaloid with PTP-1B inhibitory activity, in 10 steps. Over the course of this study, two key methodological advances were made: a cost effective procedure for ketone alpha,beta-dehydrogenation using allyl-Pd catalysis, and a Pd-catalyzed protocol to convert epoxyketones to 1,3-diketones. The central tetrasubstituted pyridine is formed by a convergent Knoevenagel condensation and carbonyl-selective electrocyclization cascade, which was followed by a direct transformation of a 2<i>H</i>-pyran to a pyridine. These studies have led to the structural revision of two members of this family.

Total Synthesis of Hibispeptin A via Pd-Catalyzed C(sp3)–H Arylation with Sterically Hindered Aryl Iodides

2014 ◽  
Vol 16 (24) ◽  
pp. 6488-6491 ◽  
Author(s):  
Gang He ◽  
Shu-Yu Zhang ◽  
William A. Nack ◽  
Ryan Pearson ◽  
Javon Rabb-Lynch ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Aryl Iodides ◽  
Sterically Hindered

Total synthesis of (±) - isosesquicarene: A structural revision

1983 ◽  
Vol 24 (41) ◽  
pp. 4445-4446 ◽  
Author(s):  
Tadao Uyehara ◽  
Jun-ichi Yamada ◽  
Tadahiro Kato ◽  
Ferdinand Bohlmann
Keyword(s):  
Total Synthesis ◽  
Structural Revision

ChemInform Abstract: Total Synthesis and Structural Revision of the Alkaloid Incargranine B.

ChemInform ◽  
2014 ◽  
Vol 45 (21) ◽  
pp. no-no
Author(s):  
Patrick D. Brown ◽  
Anthony C. Willis ◽  
Michael S. Sherburn ◽  
Andrew L. Lawrence
Keyword(s):  
Total Synthesis ◽  
Structural Revision

Total Synthesis and Structural Revision of Clavilactone D

2017 ◽  
Vol 23 (16) ◽  
pp. 3828-3831 ◽  
Author(s):  
Ken-ichi Takao ◽  
Ryuichi Nemoto ◽  
Kento Mori ◽  
Ayumi Namba ◽  
Keisuke Yoshida ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Structural Revision

scholarly journals Total Synthesis and Structural Revision of Viridicatumtoxin B

2013 ◽  
Vol 52 (33) ◽  
pp. 8736-8741 ◽  
Author(s):  
K. C. Nicolaou ◽  
Christian Nilewski ◽  
Christopher R. H. Hale ◽  
Heraklidia A. Ioannidou ◽  
Abdelatif ElMarrouni ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Structural Revision
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