Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium

2014 ◽  
Vol 126 (30) ◽  
pp. 7990-7993 ◽  
Author(s):  
Sacha Pidot ◽  
Keishi Ishida ◽  
Michael Cyrulies ◽  
Christian Hertweck
Keyword(s):  
Anaerobic Bacterium ◽  
Strictly Anaerobic ◽  
Polyketide Antibiotic

ChemInform Abstract: Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium.

ChemInform ◽  
2014 ◽  
Vol 46 (2) ◽  
pp. no-no
Author(s):  
Sacha Pidot ◽  
Keishi Ishida ◽  
Michael Cyrulies ◽  
Christian Hertweck
Keyword(s):  
Anaerobic Bacterium ◽  
Strictly Anaerobic ◽  
Polyketide Antibiotic

Discovery of Clostrubin, an Exceptional Polyphenolic Polyketide Antibiotic from a Strictly Anaerobic Bacterium

2014 ◽  
Vol 53 (30) ◽  
pp. 7856-7859 ◽  
Author(s):  
Sacha Pidot ◽  
Keishi Ishida ◽  
Michael Cyrulies ◽  
Christian Hertweck
Keyword(s):  
Anaerobic Bacterium ◽  
Strictly Anaerobic ◽  
Polyketide Antibiotic

scholarly journals Conversion of Daidzein and Genistein by an Anaerobic Bacterium Newly Isolated from the Mouse Intestine

2008 ◽  
Vol 74 (15) ◽  
pp. 4847-4852 ◽  
Author(s):  
Anastasia Matthies ◽  
Thomas Clavel ◽  
Michael Gütschow ◽  
Wolfram Engst ◽  
Dirk Haller ◽  
...  
Keyword(s):  
Stationary Phase ◽  
Enzyme Induction ◽  
Growth Phase ◽  
Anaerobic Bacterium ◽  
Stationary Growth Phase ◽  
Gut Bacteria ◽  
Soy Isoflavones ◽  
Strictly Anaerobic ◽  
Stationary Growth ◽  
Mouse Intestine

ABSTRACT The metabolism of isoflavones by gut bacteria plays a key role in the availability and bioactivation of these compounds in the intestine. Daidzein and genistein are the most common dietary soy isoflavones. While daidzein conversion yielding equol has been known for some time, the corresponding formation of 5-hydroxy-equol from genistein has not been reported previously. We isolated a strictly anaerobic bacterium (Mt1B8) from the mouse intestine which converted daidzein via dihydrodaidzein to equol as well as genistein via dihydrogenistein to 5-hydroxy-equol. Strain Mt1B8 was a gram-positive, rod-shaped bacterium identified as a member of the Coriobacteriaceae. Strain Mt1B8 also transformed dihydrodaidzein and dihydrogenistein to equol and 5-hydroxy-equol, respectively. The conversion of daidzein, genistein, dihydrodaidzein, and dihydrogenistein in the stationary growth phase depended on preincubation with the corresponding isoflavonoid, indicating enzyme induction. Moreover, dihydrogenistein was transformed even more rapidly in the stationary phase when strain Mt1B8 was grown on either genistein or daidzein. Growing the cells on daidzein also enabled conversion of genistein. This suggests that the same enzymes are involved in the conversion of the two isoflavones.

scholarly journals Covalent Linkage of Polyamines to Peptidoglycan inAnaerovibrio lipolytica

2000 ◽  
Vol 182 (4) ◽  
pp. 1154-1157 ◽  
Author(s):  
Takashi Hirao ◽  
Masahide Sato ◽  
Akira Shirahata ◽  
Yoshiyuki Kamio
Keyword(s):  
Glutamic Acid ◽  
Anaerobic Bacterium ◽  
Diaminopimelic Acid ◽  
Molar Ratio ◽  
Carboxyl Group ◽  
Strictly Anaerobic ◽  
Amino Group ◽  
Peptide Fragments ◽  
Covalent Linkage ◽  
Glutamic Acid Residue

ABSTRACT Spermidine and cadaverine were found to be constituents of the cell wall peptidoglycan of Anaerovibrio lipolytica, a strictly anaerobic bacterium. The peptidoglycan was degraded with theN-acetylmuramyl-l-alanine amidase and endopeptidase into two peptide fragments, peptide I and peptide II, at a molar ratio of 4:1. Peptides I and II were identified asl-alanine–d-glutamic acid(αcadaverine)γ meso-diaminopimelic acid (DAP)–d-alanine andl-alanine–d-glutamic acid(αspermidine)γ meso-DAP–d-alanine, respectively. The N1-amino group of spermidine was linked to the α-carboxyl group of the d-glutamic acid residue of peptide II.

scholarly journals Fermentative degradation of glyoxylate by a new strictly anaerobic bacterium

1991 ◽  
Vol 156 (5) ◽  
pp. 392-397 ◽  
Author(s):  
Michael Friedrich ◽  
Bernhard Schink
Keyword(s):  
Anaerobic Bacterium ◽  
Strictly Anaerobic

Thermophagus xiamenensis gen. nov., sp. nov., a moderately thermophilic and strictly anaerobic bacterium isolated from hot spring sediment

2013 ◽  
Vol 63 (Pt_1) ◽  
pp. 109-113 ◽  
Author(s):  
Zhao-Ming Gao ◽  
Xin Liu ◽  
Xi-Ying Zhang ◽  
Ling-Wei Ruan
Keyword(s):  
16S Rrna ◽  
Type Species ◽  
Anaerobic Bacterium ◽  
Hot Spring ◽  
Rrna Gene ◽  
Strictly Anaerobic ◽  
Content Type ◽  
Moderately Thermophilic ◽  
Link Type ◽  
The Family

A moderately thermophilic and strictly anaerobic bacterium, designated HS1T, was isolated from offshore hot spring sediment in Xiamen, China. Cells were Gram-negative, catalase-positive, oxidase-negative, slender and flexible rods without flagella. The strain could grow at 35–55 °C (optimum at 50 °C) and in 1–8 % NaCl (w/v; optimum 2–4 %). Phylogenetic analysis based on 16S rRNA gene sequences showed that strain HS1T was affiliated with the family Marinilabiliaceae and shared a distant relationship with the previously described genera. The isolate was most closely related to Anaerophaga thermohalophila Fru22T with 16S rRNA gene sequence similarity of 92.4 %, followed by the other members of the family Marinilabiliaceae with 88.7–91.1 % similarity. The dominant cellular fatty acids were iso-C15 : 0 and anteiso-C15 : 0. The predominant quinone was MK-7. The major polar lipids were phosphatidylethanolamine (PE) and an unknown polar lipid. The genomic DNA G+C content was 38.7 mol%. Besides the phylogenetically distant relationship, strain HS1T was obviously distinguished from the most closely related genera in several phenotypic properties including colony colour and pigment production, optimal temperature, optimal NaCl, relation to O2, bicarbonate/carbonate requirement, catalase activity, nitrate reduction, fermentation products and cellular fatty acid profile. Based on the phenotypic and phylogenetic data, strain HS1T represents a novel species of a new genus, for which the name Thermophagus xiamenensis gen. nov., sp. nov. is proposed. The type strain of the type species is HS1T ( = DSM 19012T = CGMCCC 1.5071T).

Occurrence and Species Distribution of Strictly Anaerobic Bacterium Pectinatus in Brewery Bottling Halls

Cerevisia ◽  
2013 ◽  
Vol 38 (2) ◽  
pp. 59
Author(s):  
D. Matoulkova ◽  
K. Kosar ◽  
M. Slaby ◽  
K. Sigler
Keyword(s):  
Species Distribution ◽  
Anaerobic Bacterium ◽  
Strictly Anaerobic

scholarly journals Genome Sequence of the Poly-3-Hydroxybutyrate Producer Clostridium acetireducens DSM 10703

2016 ◽  
Vol 4 (6) ◽  
Author(s):  
Sebastian Flüchter ◽  
Anja Poehlein ◽  
Bettina Schiel-Bengelsdorf ◽  
Rolf Daniel ◽  
Peter Dürre
Keyword(s):  
Genome Sequence ◽  
Anaerobic Bacterium ◽  
Draft Genome ◽  
Strictly Anaerobic ◽  
Circular Chromosome ◽  
Protein Encoding ◽  
Encoding Genes

Here, we report the genome sequence of Clostridium acetireducens (DSM 10703 T ), a strictly anaerobic bacterium capable of fermenting acetate and leucine to butyrate, isovalerate, and poly-3-hydroxybutyrate. The draft genome consists of a circular chromosome with a size of 2.4 Mb and harbors 2,239 predicted protein-encoding genes.

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