Cooperative Activation with Chiral Nucleophilic Catalysts andN-Haloimides: Enantioselective Iodolactonization of 4-Arylmethyl-4-pentenoic Acids

2014 ◽  
Vol 126 (27) ◽  
pp. 7094-7097 ◽  
Author(s):  
Hidefumi Nakatsuji ◽  
Yasuhiro Sawamura ◽  
Akira Sakakura ◽  
Kazuaki Ishihara
Keyword(s):  
Cooperative Activation ◽  
Nucleophilic Catalysts

Are amines basic or nucleophilic catalysts for oxirane ring opening by proton-donating nucleophiles?

2016 ◽  
Vol 57 (1) ◽  
pp. 47-51 ◽  
Author(s):  
S. G. Bakhtin ◽  
E. N. Shved ◽  
Yu. N. Bespal’ko
Keyword(s):  
Ring Opening ◽  
Oxirane Ring ◽  
Nucleophilic Catalysts

2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases

APOPTOSIS ◽  
2004 ◽  
Vol 9 (3) ◽  
pp. 323-332 ◽  
Author(s):  
L. Wood ◽  
M. P. Leese ◽  
A. Mouzakiti ◽  
A. Purohit ◽  
B. V. L. Potter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cooperative Activation

Fabrication of flexible Co‐salen integrated polymers for hydration of epoxides and alkynes via cooperative activation

ChemNanoMat ◽  
2021 ◽  
Author(s):  
He Li ◽  
Jian Chen ◽  
Jiali Liu ◽  
Chunzhi Li ◽  
Lina Liu ◽  
...  
Keyword(s):  
Cooperative Activation

Dinuclear zinc-catalyzed asymmetric [3+2] cyclization reaction for direct assembly of chiral α-amino-γ-butyrolactones bearing three stereocenters

2021 ◽  
Author(s):  
Wen-Peng Yang ◽  
Shi-Kun Jia ◽  
Tian-Tian Liu ◽  
Yuan-Zhao Hua ◽  
Mincan Wang
Keyword(s):  
Lewis Acid ◽  
Cyclization Reaction ◽  
Activation Model ◽  
Direct Assembly ◽  
Brønsted Base ◽  
Cooperative Activation

An efficient enantioselective [3+2] cyclization reaction of α-hydroxy-1-indanones and alkylidene azlactones has been developed with chiral dinuclear zinc catalysts via a Brønsted base and Lewis acid cooperative activation model. This...

Cooperative activation in cardiac muscle: impact of sarcomere length

2002 ◽  
Vol 282 (3) ◽  
pp. H1055-H1062 ◽  
Author(s):  
David P. Dobesh ◽  
John P. Konhilas ◽  
Pieter P. de Tombe
Keyword(s):  
Sarcomere Length ◽  
Linear Regression Analysis ◽  
Multiple Linear Regression Analysis ◽  
Significant Function ◽  
Cardiac Myofilament ◽  
Data Points ◽  
On Line ◽  
The Impact ◽  
Cooperative Activation ◽  
Force Relationship

This study was undertaken to determine the impact of sarcomere length (SL) on the level of cooperative activation of the cardiac myofilament at physiological [Mg2+]. Active force development was measured in skinned rat cardiac trabeculae as a function of free [Ca2+] at five SLs (1.85–2.25 μm; 1 mM free [Mg2+]; 15°C). Only muscle preparations with minimal force rundown during the entire protocol were included in the analysis (average 7.2 ± 1.7%). Median SL was measured by on-line computer video micrometry and controlled within 0.01 μm. Care was taken to ensure a sufficient number of data points in the steep portion of the [Ca2+]-force relationship at every SL to allow for accurate fit of the data to a modified Hill equation. Multiple linear regression analysis of the fit parameters revealed that both maximum, Ca2+-saturated force and Ca2+sensitivity were a significant function of SL ( P < 0.001), whereas the level of cooperativity did not depend on SL ( P = 0.2). Further analysis of the [Ca2+]-force relationships revealed a marked asymmetry that, also, was not affected by SL ( P = 0.2–0.6). Finally, we found that the level of cooperativity in isolated skinned myocardium was comparable to that reported for intact, nonskinned myocardium. Our results suggest that an increase in SL induces an increase in the Ca2+ responsiveness of the cardiac sarcomere without affecting the level of cooperativity.

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