Innenrücktitelbild: Formation of a Homo Double Helix of a Conjugated Polymer with Carboxy Groups and Amplification of the Macromolecular Helicity by Chiral Amines Sandwiched between the Strands (Angew. Chem. 20/2013)

2013 ◽  
Vol 125 (20) ◽  
pp. 5517-5517
Author(s):  
Wataru Makiguchi ◽  
Shinzo Kobayashi ◽  
Yoshio Furusho ◽  
Eiji Yashima
Keyword(s):  
Conjugated Polymer ◽  
Double Helix ◽  
Chiral Amines

scholarly journals Innenrücktitelbild: Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines (Angew. Chem. 19/2020)

2020 ◽  
Vol 132 (19) ◽  
pp. 7695-7695
Author(s):  
Akio Urushima ◽  
Daisuke Taura ◽  
Makoto Tanaka ◽  
Naomichi Horimoto ◽  
Junki Tanabe ◽  
...  
Keyword(s):  
Double Helix ◽  
Chiral Amines ◽  
Helix Formation

scholarly journals Helical springs as a color indicator for determining chirality and enantiomeric excess

2021 ◽  
Vol 7 (27) ◽  
pp. eabg5381
Author(s):  
Katsuhiro Maeda ◽  
Daisuke Hirose ◽  
Mai Nozaki ◽  
Yoichi Shimizu ◽  
Taro Mori ◽  
...  
Keyword(s):  
Conjugated Polymer ◽  
Enantiomeric Excess ◽  
Chiral Amines ◽  
Polymer Backbone ◽  
Helical Springs ◽  
Color Changes ◽  
Unique Color ◽  
Site Monitoring ◽  
Color Indicator

Chirality plays a key role in the physiological system, because molecular functionalities may drastically alter due to a change in chirality. We report herein a unique color indicator with a static helicity memory, which exhibits visible color changes in response to the chirality of chiral amines. A difference of less than 2% in the enantiomeric excess (ee) values causes a change in the absorption that is visible to the naked eyes. This was further quantified by digital photography by converting to RGB values. This system relies on the change in the tunable helical pitch of the π-conjugated polymer backbone in specific solvents and allows rapid on-site monitoring of chirality of nonracemic amines, including drugs, and the simultaneous quantitative determination of their ee values.

Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines

2020 ◽  
Vol 59 (19) ◽  
pp. 7478-7486 ◽  
Author(s):  
Akio Urushima ◽  
Daisuke Taura ◽  
Makoto Tanaka ◽  
Naomichi Horimoto ◽  
Junki Tanabe ◽  
...  
Keyword(s):  
Double Helix ◽  
Chiral Amines ◽  
Helix Formation

Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines

2020 ◽  
Vol 132 (19) ◽  
pp. 7548-7556 ◽  
Author(s):  
Akio Urushima ◽  
Daisuke Taura ◽  
Makoto Tanaka ◽  
Naomichi Horimoto ◽  
Junki Tanabe ◽  
...  
Keyword(s):  
Double Helix ◽  
Chiral Amines ◽  
Helix Formation

Protamine-DNA interaction

1978 ◽  
Vol 36 (2) ◽  
pp. 200-201
Author(s):  
D.P. Bazett-Jones ◽  
F.P. Ottensmeyer
Keyword(s):  
Small Volume ◽  
Double Helix ◽  
Dna Interaction ◽  
Dark Field ◽  
Sperm Head ◽  
Nuclear Proteins ◽  
Field Electron Microscopy ◽  
Dark Field Electron ◽  
Dna Double Helix ◽  
Positively Charged

Dark field electron microscopy has been used for the study of the structure of individual macromolecules with a resolution to at least the 5Å level. The use of this technique has been extended to the investigation of structure of interacting molecules, particularly the interaction between DNA and fish protamine, a class of basic nuclear proteins of molecular weight 4,000 daltons.Protamine, which is synthesized during spermatogenesis, binds to chromatin, displaces the somatic histones and wraps up the DNA to fit into the small volume of the sperm head. It has been proposed that protamine, existing as an extended polypeptide, winds around the minor groove of the DNA double helix, with protamine's positively-charged arginines lining up with the negatively-charged phosphates of DNA. However, viewing protamine as an extended protein is inconsistent with the results obtained in our laboratory.

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