scholarly journals Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

2012 ◽  
Vol 124 (44) ◽  
pp. 11235-11240 ◽  
Author(s):  
Marco Di Antonio ◽  
Giulia Biffi ◽  
Angelica Mariani ◽  
Eun-Ang Raiber ◽  
Raphaël Rodriguez ◽  
...  
Keyword(s):  
Click Chemistry ◽  
G Quadruplex

scholarly journals Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry

2012 ◽  
Vol 51 (44) ◽  
pp. 11073-11078 ◽  
Author(s):  
Marco Di Antonio ◽  
Giulia Biffi ◽  
Angelica Mariani ◽  
Eun-Ang Raiber ◽  
Raphaël Rodriguez ◽  
...  
Keyword(s):  
Click Chemistry ◽  
G Quadruplex

scholarly journals Inside Cover: Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry (Angew. Chem. Int. Ed. 44/2012)

2012 ◽  
Vol 51 (44) ◽  
pp. 10906-10906
Author(s):  
Marco Di Antonio ◽  
Giulia Biffi ◽  
Angelica Mariani ◽  
Eun-Ang Raiber ◽  
Raphaël Rodriguez ◽  
...  
Keyword(s):  
Click Chemistry ◽  
G Quadruplex

scholarly journals A new application of click chemistry in situ: development of fluorescent probe for specific G-quadruplex topology

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Ming-Hao Hu ◽  
Xiao Chen ◽  
Shuo-Bin Chen ◽  
Tian-Miao Ou ◽  
Meicun Yao ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Fluorescent Probe ◽  
G Quadruplex

Innentitelbild: Selective RNA Versus DNA G-Quadruplex Targeting by In Situ Click Chemistry (Angew. Chem. 44/2012)

2012 ◽  
Vol 124 (44) ◽  
pp. 11064-11064
Author(s):  
Marco Di Antonio ◽  
Giulia Biffi ◽  
Angelica Mariani ◽  
Eun-Ang Raiber ◽  
Raphaël Rodriguez ◽  
...  
Keyword(s):  
Click Chemistry ◽  
G Quadruplex

scholarly journals Voltammetry and molecular assembly of G-quadruplex DNAzyme on single-crystal Au(111)-electrode surfaces – hemin as an electrochemical intercalator

2016 ◽  
Vol 193 ◽  
pp. 99-112 ◽  
Author(s):  
Ling Zhang ◽  
Jens Ulstrup ◽  
Jingdong Zhang
Keyword(s):  
Single Crystal ◽  
Single Molecule ◽  
Electrode Surface ◽  
Molecular Assembly ◽  
Electrode Surfaces ◽  
Potential Control ◽  
G Quadruplex ◽  
Tunnelling Microscopy ◽  
Dna Quadruplexes

DNA quadruplexes (qs) are a class of “non-canonical” oligonucleotides (OGNs) composed of stacked guanine (G) quartets stabilized by specific cations. Metal porphyrins selectively bind to G-qs complexes to form what is known as DNAzyme, which can exhibit peroxidase and other catalytic activity similar to heme group metalloenzymes. In the present study we investigate the electrochemical properties and the structure of DNAzyme monolayers on single-crystal Au(111)-electrode surfaces using cyclic voltammetry and scanning tunnelling microscopy under electrochemical potential control (in situ STM). The target DNAzyme is formed from a single-strand OGN with 12 guanines and iron(iii) porphyrin IX (hemin), and assembles on Au(111) through a mercapto alkyl linker. The DNAzyme monolayers exhibit a strong pair of redox peaks at 0.0 V (NHE) at pH 7 in acetate buffer, shifted positively by about 50 mV compared to free hemin weakly physisorbed on the Au(111)-electrode surface. The voltammetric hemin signal of DNAzyme is enhanced 15 times compared with that of hemin adsorbed directly on the Au(111)-electrode surface. This is indicative of both the formation of a close to dense DNAzyme monolayer and that hemin is strongly bound to the immobilized 12G-qs in well-defined orientation favorable for interfacial ET with a rate constant of 6.0 ± 0.4 s−1. This is supported by in situ STM which discloses single-molecule G-quartet structures with a size of 1.6 ± 0.2 nm.

In Situ Generation of Copper Nanoparticles by Rongalite and Their Use as Catalyst for Click Chemistry in Water

2018 ◽  
Vol 3 (48) ◽  
pp. 13759-13764 ◽  
Author(s):  
Soumya Poshala ◽  
Sanjeeva Thunga ◽  
Saikumar Manchala ◽  
Hari Prasad Kokatla
Keyword(s):  
Click Chemistry ◽  
Copper Nanoparticles ◽  
In Situ Generation
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