Highly Diastereo- and Enantioselective Synthesis of α-Alkyl Norstatine Derivatives: Catalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones

2012 ◽  
Vol 124 (30) ◽  
pp. 7641-7645 ◽  
Author(s):  
Depeng Zhao ◽  
Linqing Wang ◽  
Dongxu Yang ◽  
Yixin Zhang ◽  
Rui Wang
Keyword(s):  
Enantioselective Synthesis ◽  
Mannich Reactions ◽  
Catalytic Asymmetric

scholarly journals Enantioselective synthesis of (−)-chloramphenicol via silver-catalysed asymmetric isocyanoacetate aldol reaction

2016 ◽  
Vol 14 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Allegra Franchino ◽  
Pavol Jakubec ◽  
Darren J. Dixon
Keyword(s):  
Aldol Reaction ◽  
Enantioselective Synthesis ◽  
Asymmetric Aldol ◽  
Asymmetric Aldol Reaction ◽  
Catalytic Asymmetric

A concise synthesis of (−)-chloramphenicol, based on the catalytic asymmetric aldol reaction between 4-nitrobenzaldehyde and benzhydryl isocyanoacetate, is reported.

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