Bifunctional Organocatalytic Strategy for Inverse-Electron-Demand Diels-Alder Reactions: Highly Efficient In Situ Substrate Generation and Activation to Construct Azaspirocyclic Skeletons

2012 ◽  
Vol 124 (9) ◽  
pp. 2126-2129 ◽  
Author(s):  
Xianxing Jiang ◽  
Xiaomei Shi ◽  
Shoulei Wang ◽  
Tao Sun ◽  
Yiming Cao ◽  
...  
Keyword(s):  
Diels Alder ◽  
Inverse Electron Demand ◽  
Highly Efficient ◽  
Electron Demand

scholarly journals Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

2015 ◽  
Vol 51 (55) ◽  
pp. 11130-11133 ◽  
Author(s):  
S. Hörner ◽  
C. Uth ◽  
O. Avrutina ◽  
H. Frauendorf ◽  
M. Wiessler ◽  
...  
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Highly Efficient ◽  
Diels Alder Reaction ◽  
Site Selective ◽  
Electron Demand

A modular bioconjugation strategy based on stepwise oxime ligation and inverse electron-demand Diels–Alder reaction.

Highly efficient method for 125I-radiolabeling of biomolecules using inverse-electron-demand Diels–Alder reaction

2016 ◽  
Vol 24 (11) ◽  
pp. 2589-2594 ◽  
Author(s):  
Mi Hee Choi ◽  
Ha Eun Shim ◽  
Seong-Jae Yun ◽  
Hye Rim Kim ◽  
Sajid Mushtaq ◽  
...  
Keyword(s):  
Efficient Method ◽  
Alder Reaction ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Highly Efficient ◽  
Diels Alder Reaction ◽  
Electron Demand

Diastereoselective Synthesis of Functionalized Tetrahydropyridazines Containing Indole Scaffolds via Inverse-Electron-Demand Aza-Diels–Alder Reaction

2021 ◽  
Author(s):  
Taotao Chen ◽  
Chao Che ◽  
Zhefei Guo ◽  
Xiu-Qin Dong ◽  
Chun-Jiang Wang
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Diastereoselective Synthesis ◽  
Inverse Electron Demand ◽  
Catalyst Free ◽  
Diels Alder Reaction ◽  
Electron Demand

An unprecedented base-promoted and catalyst-free inverse-electron-demand aza-Diels-Alder (IEDDA) reaction between the easily available in situ generated azoalkenes and 3-vinylindoles has been developed. This efficient protocol afforded structurally important tetrahydropyridazines containing...

scholarly journals Correction: Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations

2015 ◽  
Vol 51 (58) ◽  
pp. 11727-11727 ◽  
Author(s):  
S. Hörner ◽  
C. Uth ◽  
O. Avrutina ◽  
H. Frauendorf ◽  
M. Wiessler ◽  
...  
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Inverse Electron Demand ◽  
Highly Efficient ◽  
Diels Alder Reaction ◽  
Site Selective ◽  
Electron Demand

Correction for ‘Combination of inverse electron-demand Diels–Alder reaction with highly efficient oxime ligation expands the toolbox of site-selective peptide conjugations’ by S. Hörner, et al., Chem. Commun., 2015, DOI: 10.1039/c5cc03434e.

scholarly journals Bay-Region-Selective Annulative π-Extension (APEX) of Perylene Diimides with Arynes

Synlett ◽  
2019 ◽  
Vol 30 (04) ◽  
pp. 423-428 ◽  
Author(s):  
Takayuki Nakamuro ◽  
Kazushi Kumazawa ◽  
Hideto Ito ◽  
Kenichiro Itami
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Short Axis ◽  
One Pot ◽  
Perylene Diimides ◽  
Inverse Electron Demand ◽  
Diels Alder Reaction ◽  
Electron Demand

A bay-region-selective annulative π-extension (APEX) reaction of perylene diimides (PDIs) has been achieved by means of in-situ generated reactive aryne intermediates. This method provides an efficient one-pot π-extension at the short axis of PDIs in a sequential manner. Mechanistically, an inverse-electron-demand Diels–Alder reaction might be operative for the transformation.

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