Palladium-Catalyzed CC Bond Formation To Construct 1,4-Diketones under Mild Conditions

2011 ◽  
Vol 123 (32) ◽  
pp. 7475-7479 ◽  
Author(s):  
Chao Liu ◽  
Yi Deng ◽  
Jing Wang ◽  
Yingying Yang ◽  
Shan Tang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Mild Conditions ◽  
Palladium Catalyzed

Palladium-Catalyzed CC Bond Formation To Construct 1,4-Diketones under Mild Conditions

2011 ◽  
Vol 50 (32) ◽  
pp. 7337-7341 ◽  
Author(s):  
Chao Liu ◽  
Yi Deng ◽  
Jing Wang ◽  
Yingying Yang ◽  
Shan Tang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Mild Conditions ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed C-C Bond Formation to Construct 1,4-Diketones under Mild Conditions.

ChemInform ◽  
2011 ◽  
Vol 42 (52) ◽  
pp. no-no
Author(s):  
Chao Liu ◽  
Yi Deng ◽  
Jing Wang ◽  
Yingying Yang ◽  
Shan Tang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Mild Conditions ◽  
Palladium Catalyzed

Palladium-catalyzed cascade cyclizations involving C–C and C–X bond formation: strategic applications in natural product synthesis

2021 ◽  
Author(s):  
K. R. Holman ◽  
A. M. Stanko ◽  
S. E. Reisman
Keyword(s):  
Natural Product ◽  
Bond Formation ◽  
Natural Product Synthesis ◽  
Cascade Cyclizations ◽  
Palladium Catalyzed ◽  
Multiple Rings

This tutorial review highlights the use of palladium-catalyzed cascade cyclizations in natural product synthesis, focusing on cascades that construct multiple rings and form both C–C and C–X (X = O, N) bonds in a single synthetic operation.

scholarly journals Continuous-Flow Processes for the Production of Floxacin Intermediates: Efficient C–C Bond Formation through a Rapid and Strong Activation of Carboxylic Acids

2020 ◽  
Vol 02 (03) ◽  
pp. e128-e132
Author(s):  
Shao-Zheng Guo ◽  
Zhi-Qun Yu ◽  
Wei-Ke Su
Keyword(s):  
Reaction Time ◽  
Continuous Flow ◽  
Flow System ◽  
Bond Formation ◽  
Product Yield ◽  
Raw Material ◽  
Material Consumption ◽  
Tank Reactor ◽  
Mild Conditions ◽  
Flow Processes

AbstractThe development of highly efficient C–C bond formation methods for the synthesis of ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-(dimethylamino)acrylate 1 in continuous flow processes has been described, which is based on the concept of rapid and efficient activation of carboxylic acid. 2,4-Dichloro-5-fluorobenzoic acid is rapidly converted into highly reactive 2,4-dichloro-5-fluorobenzoyl chloride by treating with inexpensive and less-toxic solid bis(trichloromethyl)carbonate. And then it rapidly reacts with ethyl 3-(dimethylamino)acrylate to afford the desired 1. This process can be performed under mild conditions. Compared with the traditional tank reactor process, less raw material consumption, higher product yield, less reaction time, higher operation safety ensured by more the environmentally friendly procedure, and process continuity are achieved in the continuous-flow system.

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