scholarly journals Total Synthesis of Lipoteichoic Acid of Streptococcus pneumoniae

2010 ◽  
Vol 122 (14) ◽  
pp. 2639-2644 ◽  
Author(s):  
Christian Marcus Pedersen ◽  
Ignacio Figueroa-Perez ◽  
Buko Lindner ◽  
Artur J. Ulmer ◽  
Ulrich Zähringer ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Total Synthesis ◽  
Lipoteichoic Acid

scholarly journals R-roscovitine Reduces Lung Inflammation Induced by Lipoteichoic Acid and Streptococcus pneumoniae

2012 ◽  
Vol 18 (7) ◽  
pp. 1086-1095 ◽  
Author(s):  
Arie J. Hoogendijk ◽  
Joris J. T. H. Roelofs ◽  
JanWillem Duitman ◽  
Miriam H. P. van Lieshout ◽  
Dana C. Blok ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Lung Inflammation ◽  
Lipoteichoic Acid

scholarly journals Unique poly(glycerophosphate) lipoteichoic acid and the glycolipids of a Streptococcus sp. closely related to Streptococcus pneumoniae

2000 ◽  
Vol 267 (17) ◽  
pp. 5520-5530 ◽  
Author(s):  
Peter Roethlisberger ◽  
Naoko Iida-Tanaka ◽  
Klaus Hollemeyer ◽  
Elmar Heinzle ◽  
Ineo Ishizuka ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Lipoteichoic Acid

scholarly journals Quantitation in the regioselectivity of acylation of glycosyl diglycerides: total synthesis of a Streptococcus pneumoniae α-glucosyl diglyceride

2017 ◽  
Vol 53 (6) ◽  
pp. 1100-1103 ◽  
Author(s):  
Mark B. Richardson ◽  
Dylan G. M. Smith ◽  
Spencer J. Williams
Keyword(s):  
Fatty Acids ◽  
Streptococcus Pneumoniae ◽  
Nmr Spectroscopy ◽  
Total Synthesis ◽  
C Nmr

Regioselective fidelity of acylation of glycosyl diacylglycerols can be monitored by use of isotope-labelled fatty acids and quantitative 13C NMR spectroscopy.

scholarly journals Lipoteichoic acid of Streptococcus oralis Uo5: a novel biochemical structure comprising an unusual phosphorylcholine substitution pattern compared to Streptococcus pneumoniae

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Nicolas Gisch ◽  
Dominik Schwudke ◽  
Simone Thomsen ◽  
Nathalie Heß ◽  
Regine Hakenbeck ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Teichoic Acid ◽  
Structural Complexity ◽  
Lipoteichoic Acid ◽  
Close Relative ◽  
Structural Variations ◽  
Wall Teichoic Acid ◽  
Substitution Pattern ◽  
Type Iv ◽  
Streptococcus Oralis

Abstract Members of the Mitis group of streptococci possess teichoic acids (TAs) as integral components of their cell wall that are unique among Gram-positive bacteria. Both, lipoteichoic (LTA) and wall teichoic acid, are formed by the same biosynthetic pathway, are of high complexity and contain phosphorylcholine (P-Cho) residues. These residues serve as anchors for choline-binding proteins (CBPs), some of which have been identified as virulence factors of the human pathogen Streptococcus pneumoniae. We investigated the LTA structure of its close relative Streptococcus oralis. Our analysis revealed that S. oralis Uo5 LTA has an overall architecture similar to pneumococcal LTA (pnLTA) and can be considered as a subtype of type IV LTA. Its structural complexity is even higher than that of pnLTA and its composition differs in number and type of carbohydrate moieties, inter-residue connectivities and especially the P-Cho substitution pattern. Here, we report the occurrence of a saccharide moiety substituted with two P-Cho residues, which is unique as yet in bacterial derived surface carbohydrates. Finally, we could link the observed important structural variations between S. oralis and S. pneumoniae LTA to the divergent enzymatic repertoire for their TA biosynthesis.

Total Synthesis of Lipoteichoic Acid ofStreptococcus pneumoniae

2010 ◽  
Vol 49 (14) ◽  
pp. 2585-2590 ◽  
Author(s):  
Christian Marcus Pedersen ◽  
Ignacio Figueroa-Perez ◽  
Buko Lindner ◽  
Artur J. Ulmer ◽  
Ulrich Zähringer ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Lipoteichoic Acid
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